1,642 research outputs found
Monoclonal antibodies and small-molecules as distinct subclasses of CCR5-targeted therapies for HIV-1
Variations of electrophotoluminescence phenomena with frequency of applied field
Luminescence is a general term which includes the many phenomena involving the absorption of energy by a substance and its re=emission as visible or near visible radiation. Photoluminescence implies excitation 7 by irradiation with electromagnetic radiation; cathodoluminescence implies excitation by electron bombardment; thermoluminescence or glow refers to additional excitation by heat of a phosphor previously irradiated at a low temperature; and electroluminescence implies excitation by an electric field. The most recently observed phenomena, and the subjects of this investigation are those included in the general term electrophotoluminescence which refers to the effect of an electric field on photoluminescence. Luminescence includes both fluorescence and phosphorescence. Fluoresgence refers-to the emission observed either during excitation or within 10^-8 sec after excitation has ceased. Phosphorescence refers to any omission observed later than 10^-8 sec after excitation has ceased. Most substances are not luminescent but dissipate absorbed energy in heat. A few substances dissipate absorbed energy in photoelectrons, or in other forms. This discussion will be concerned exclusively with that class of crystalline inorganic solids which exhibit phosphorescence due to controlled traces of impurity. These solids are known as phosphors
Donor-Acceptor Oligorotaxanes Made to Order
Five donor–acceptor oligorotaxanes made up of dumbbells composed of tetraethylene glycol chains, interspersed
with three and five 1,5-dioxynaphthalene units, and terminated by 2,6-diisopropylphenoxy stoppers, have been prepared by the threading of discrete numbers of cyclobis(paraquat-p-phenylene) rings, followed by a
kinetically controlled stoppering protocol that relies on click chemistry. The well-known copper(I)-catalyzed
alkyne–azide cycloaddition between azide functions placed at the ends of the polyether chains and alkyne-bearing
stopper precursors was employed during the final kinetically controlled template-directed synthesis of the five oligorotaxanes, which were characterized subsequently by ^1H NMR spectroscopy at low temperature (233 K) in
deuterated acetonitrile. The secondary structures, as well as the conformations, of the five oligorotaxanes were unraveled by spectroscopic comparison with the dumbbell and ring components. By focusing attention on the changes in
chemical shifts of some key probe protons, obtained from a wide range of low-temperature spectra, a picture emerges of a high degree of folding within the thread protons of the dumbbells of four of the five oligorotaxanes—the fifth oligorotaxane represents a control compound in effect—
brought about by a combination of C-H···O and π–π stacking interactions between the p-electron-deficient bipyridinium
units in the rings and the π-electron-rich 1,5-dioxynaphthalene units and polyether chains in the
dumbbells. The secondary structures of a foldamer-like nature have received further support from a solid-state superstructure of a related [3]pseudorotaxane and density functional calculations performed thereon
MINNESOTA CURRENT FARM SITUATION
These papers describe the current economic conditions and outline some of the opportunities facing Minnesota farmers as they complete 1998 and develop plans for 1999. The first paper, Prospects For Farm Income in 1998, describes the variation in net farm income farmers in the Southeastern and Southwestern Farm Management Associations have experienced over the past twenty years. The possible effects of 1998's low commodity prices and government program payments on net farm income are discussed in the context of this historical variation. This paper points out that some farmers are experiencing a very good year in 1998, while others may have very low net farm income this year. Those with high incomes in 1998 may be primarily interested in opportunities to enhance their cash flow for 1999, while those experiencing financial stress during 1998 may need to consider a wider range of adjustments as they plan for the coming year. The remaining papers provide information farmers may want to consider as they plan their marketing and financial strategies for the coming year. Financial Management Alternatives outlines a wide range of financial management alternatives that can be used to deal with cash flow problems. Some of these alternatives will be of interest to farmers who have difficulty in projecting a positive net cash flow with the relatively low commodity prices being projected for 1999. Others are of primary interest to farmers who have relatively high debt levels and must find ways to improve both their net cash flow and their debt/asset position. Some observers have suggested that the low commodity prices projected for 1999 may lead to reductions in cash rental rates. The paper, Cropland Rental Market Impacts of Low Crop Prices, discusses a procedure to estimate "fair rental rates", and provides an historical perspective of the impact low commodity prices have had on land rental rates. The remaining two papers, Situation and Outlook For the Livestock Sector, and Considerations in Developing a Corn/Soybean Marketing Plan for 1998/1999, discuss the major factors to evaluate and options to consider in developing a marketing plan for corn, soybeans, hogs and cattle for the coming year.Farm Management,
An efficient finite element method for treating singularities in Laplace's equation
We present a new finite element method for solving partial differential equations with singularities caused by abrupt changes in boundary conditions or sudden changes in boundary shape. Terms from the local solution supplement the ordinary basis functions in the finite element solution. All singular contributions reduce to boundary integrals after a double application of the divergence theorem to the Galerkin integrals, and the essential boundary conditions are weakly enforced using Lagrange multipliers. The proposed method eliminates the need for high-order integration, improves the overall accuracy, and yields very accurate estimates for the singular coefficients. It also accelerates the convergence with regular mesh refinement and converges rapidly with the number of singular functions. Although here we solve the Laplace equation in two dimensions, the method is applicable to a more general class of problems.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29107/1/0000145.pd
A Detailed Examination of the GPM Core Satellite Gridded Text Product
The Global Precipitation Measurement (GPM) mission quarter-degree gridded-text product has a similar file format and a similar purpose as the Tropical Rainfall Measuring Mission (TRMM) 3G68 quarter-degree product. The GPM text-grid format is an hourly summary of surface precipitation retrievals from various GPM instruments and combinations of GPM instruments. The GMI Goddard Profiling (GPROF) retrieval provides the widest swath (800 km) and does the retrieval using the GPM Microwave Imager (GMI). The Ku radar provides the widest radar swath (250 km swath) and also provides continuity with the TRMM Ku Precipitation Radar. GPM's Ku+Ka band matched swath (125 km swath) provides a dual-frequency precipitation retrieval. The "combined" retrieval (125 km swath) provides a multi-instrument precipitation retrieval based on the GMI, the DPR Ku radar, and the DPR Ka radar. While the data are reported in hourly grids, all hours for a day are packaged into a single text file that is g-zipped to reduce file size and to speed up downloading. The data are reported on a 0.25deg x 0.25 deg grid
Ionic Accumulation in Citrus as Influenced by Rootstock and Scion and Concentration of Salts and Boron in the Substrate
Genome-wide screening for DNA variants associated with reading and language traits
This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills.Publisher PDFPeer reviewe
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