Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment

El pdf del artículo es la versión pre-print.The prefrontal cortex (PFC) has attracted a great research interest because of its involvement in the control of executive functions in both health and disease, and particularly in cognitive functions such as working memory. In schizophrenia, alterations in the PFC are documented at many different levels: molecular, cellular and functional. Furthermore, deficits in cognitive abilities are considered a core feature of schizophrenia and remain a major unmet medical need with respect to this disorder. In order to understand the sites of action of currently used drugs, as well as of the new experimental treatments being developed and acting in this brain region, it is important to have a detailed knowledge of the corresponding chemical neuroanatomy. Here we review current knowledge regarding the cellular localization of 5-HT1A, 5-HT2A and dopamine D1, D5, and D2, D4 receptors in primate PFC and their possible functions in the neuronal circuits of the PFC.J. de Almeida is the recipient of a fellowship from the Spanish Ministry of Education. This research was funded by the Fundació La Marató TV3 (#01/3930). Support from the Generalitat de Catalunya (Grup de Recerca de Qualitat 2005-SGR0758) is also acknowledged.Peer reviewe

Метод экспертных оценок в лингводидактике

Рассматривается использование метода экспертных оценок как в общей системе научно-педагогической экспертной деятельности, так и в рамках ее лингводидактического аспекта. Дается характеристика процедуры проведения экспертизы, а также оценивается перспективность обращения к интеллектуальным компьютерным системам как инструментам экспертного анализа

Быстродействующая система стабилизации переменного напряжения

Рассматривается система стабилизации переменного напряжения на основе магнитно-полупроводникового регулятора без подмагничивания постоянным током и быстродействующей обратной связи. По описанному принципу могут быть построены быстродействующие однофазные и трехфазные стабилизаторы напряжения на встречно-параллельных управляемых вентилях при их естественной или принудительной коммутации

Плазменная переработка порошков оксидов металлов

Исследования направлены на изучение микроструктуры порошка, прошедшего плазменную обработку. Особое внимание будет уделено сохранности порошка количества порошкаThe research is aimed at studying the microstructure of the powder that has undergone plasma treatment. Particular attention will be paid to the preservation of the amount of powder

Extending the process limits of laser polymer welding with high-brilliance beam sources (recent status and prospects of POLYBRIGHT)

Plastics play an important role in almost every facet of our lives and constitute a wide variety of products, from everyday products such as food and beverage packaging, over furniture and building materials to high tech products in the automotive, electronics, aerospace, white goods, medical and other sectors [1]. The objective of PolyBright, the European Research project on laser polymer welding, is to provide high speed and flexible laser manufacturing technology and expand the limits of current plastic part assembly. New laser polymer joining processes for optimized thermal management in combination with adapted wavelengths will provide higher quality, high processing speed up to 1 m/s and robust manufacturing processes at lower costs. Key innovations of the PolyBright project are fibre lasers with high powers up to 500 W, high speed scanning and flexible beam manipulation systems for simultaneous welding and high-resolution welding, such as dynamic masks and multi kHz scanning heads. With this initial step, PolyBright will break new paths in processing of advanced plastic products overcoming the quality and speed limitations of conventional plastic part assembly. Completely new concepts for high speed processing, flexibility and quality need to be established in combination with high brilliance lasers and related equipment. PolyBright will thus open new markets for laser systems with a short term potential of over several 100 laser installations per year and a future much larger market share in the still growing plastic market. PolyBright will hence establish a comprehensive and sustainable development activity on new high brilliance lasers that will strengthen the laser system industry

Laserbonding instead of ultrasonic wire bonding - an alternative joining technology for power applications

Laserbonding is a newly developed technology that combines the flexibility and robustness of classical ultrasonic wire-bonding with the advantages of laser welding as regards large connector cross-sections, low quality requirements to surf aces and clamping rigidity. Thanks to modern laser sources with high brilliance, near-infrared radiation can be used in oscillation welding Cu even in a keyhole fashion even though Cu is traditionally considered illsuited for such laser wavelengths. The process is most useful for connecting copper ribbons of 2 × 0, 2 mm size to Li battery cells of the 18650 type but can also be adapted for larger prismatic cells. Further development is geared towards connecting power semiconductors

Laserdurchstrahlschweißen von Thermoplasten: Ein Verfahren erobert den Kunststoffmarkt

Dank seiner Vorteile hat sich das Laserschweißen von Kunststoffen zu einem etablierten Fügeverfahren entwickelt und es ersetzt mehr und mehr die bisher üblichen Fügeverfahren. Neue Entwicklungen beim Laserdurchstrahlschweißen ermöglichen nun das Überschreiten bisheriger Grenzen und eröffnen diesem Schweißverfahren weitere Anwendungsfelder

Iatrogene Nervenläsionen - Häufigkeit, Detektion und Therapiekonzepte

For laser transmission welding of polypropylene carbon black and indium tin oxide (ITO) are used as absorber particles. Additionally, the colorant titanium dioxide is mixed to the absorbing part, while the transparent part is kept in natural state. The absorption coefficients of ITO and carbon black particles are obtained, as well as the scattering properties of polypropylene loaded with titanium dioxide (TiO2). At similar concentrations the absorption coefficient of ITO is an order of magnitude smaller than that of carbon black. Simulations of radiation propagation show that the penetration depth of laser light is smaller for carbon black. Therefore, the density of the released heat is higher. Adding TiO2 changes the distribution of heat in case of ITO, whereas for carbon black the effect is negligible. Thermal simulations reveal the influence of the two absorbers and TiO2 on the heat affected zone. The results of the thermal simulations are compared to tensile test results