Time-resolved nonlinear ghost imaging: route to hyperspectral single-pixel reconstruction of complex samples at THz frequencies

Terahertz (THz) is an innovative form of electromagnetic radiation providing unique spectroscopy capabilities in critical fields, ranging from biology to material science and security. The limited availability of high-resolution imaging devices, however, constitutes a major limitation in this field. In this work, we tackle this challenge by proposing an innovative type of time-space nonlinear Ghost-Imaging (GI) methodology that conceptually outperforms established single-pixel imaging protocols. Our methodology combines nonlinear pattern generation with time-resolved single-pixel measurements, as enabled by the state-of-the-art Time-Domain Spectroscopy (TDS) technique. This approach is potentially applicable to any wave-domain in which the field is a measurable quantity. The full knowledge of the temporal evolution of the transmitted field enables devising a new form of full-wave reconstruction process. This gives access not only to the morphological features of the sample with deeply subwavelength resolution but also to its local spectrum (hyperspectral imaging). As a target application, we consider hyperspectral THz imaging of a disordered inhomogeneous sample

Time-resolved nonlinear ghost imaging

Terahertz (THz) spectroscopy systems are widely employed to retrieve the chemical and material composition of a sample. This is single-handed the most important driving motivation in the field and has largely contributed to shaping THz science as an independent subject. The limited availability of high-resolution imaging devices, however, still represents a major technological challenge in this promising field of research. In this theoretical work, we tackle this challenge by developing a novel nonlinear Ghost Imaging (GI) approach that conceptually outperforms established single-pixel imaging protocols at inaccessible wavelengths. Our methodology combines nonlinear THz generation with time-resolved field measurements, as enabled by state-of-the-art Time Domain Spectroscopy (TDS) techniques. As an ideal application target, we consider hyperspectral THz imaging of semi-transparent samples with nonnegligible delay contribution and we demonstrate how time-resolved, full-wave acquisition enables accurate spatiotemporal reconstruction of complex inhomogeneous samples

The prognostic effects of circulating myeloid-derived suppressor cells in non-small cell lung cancer: systematic review and meta-analysis

Immunotherapy is the main standard treatment for non-small cell lung cancer (NSCLC) patients. Immune suppressive cells in tumor microenvironment can counteract its efficacy. Myeloid-derived suppressor cells (MDSCs) include two major subsets: polymorphonuclear (PMN-MDSCs) and monocytic (M-MDSCs). Many studies explored the prognostic impact of these cell populations in NSCLC patients. The aim of this systematic review is to select studies for a meta-analysis, which compares prognosis between patients with high vs low circulating MDSC levels. We collected hazard ratios (HRs) and relative 95% confidence intervals (CIs) in terms of progression-free survival (PFS) or recurrence-free survival (RFS), and overall survival (OS). Among 139 studies retrieved from literature search, 14 eligible studies (905 NSCLC patients) met inclusion criteria. Low circulating MDSC levels favor a better PFS/RFS (HR = 1.84; 95% CI = 1.28-2.65) and OS (HR = 1.78; 95% CI = 1.29-2.46). The subgroup analysis based on MDSC subtypes (total-, PMN-, and M-MDSCs) obtained a statistical significance only for M-MDSCs, both in terms of PFS/RFS (HR = 2.67; 95% CI = 2.04-3.50) and OS (HR = 2.10; 95% CI = 1.61-2.75). NSCLC patients bearing high M-MDSC levels in peripheral blood experience a worse prognosis than those with low levels, both in terms of PFS/RFS and OS. This finding suggests that detecting and targeting this MDSC subset could help to improve NSCLC treatment efficacy

Hyperspectral terahertz microscopy via nonlinear ghost-imaging

Ghost-imaging, based on single-pixel detection and multiple pattern illumination, is a crucial investigation tool in difficult-to-access wavelength regions. In the terahertz domain, where high-resolution imagers are mostly unavailable, Ghost-imaging is an optimal approach to embed the temporal dimension, creating a ‘hyperspectral’ imager. In this framework high-resolution is mostly out-of-reach. Hence, it is particularly critical to developing practical approaches for microscopy. Here we experimentally demonstrate Time-Resolved Nonlinear Ghost-Imaging, a technique based on near-field, optical-to-terahertz nonlinear conversion and detection of illumination patterns. We show how space-time coupling affects near-field time-domain imaging and we develop a complete methodology that overcomes fundamental systematic reconstruction issues. Our theoretical-experimental platform enables high-fidelity subwavelength imaging and carries relaxed constrains on the nonlinear generation crystal thickness. Our work establishes a rigorous framework to reconstruct hyperspectral images of complex samples inaccessible through standard fixed-time methods

Route to intelligent imaging reconstruction via terahertz nonlinear ghost imaging

Terahertz (THz) imaging is a rapidly emerging field, thanks to many potential applications in diagnostics, manufacturing, medicine and material characterisation. However, the relatively coarse resolution stemming from the large wavelength limits the deployment of THz imaging in micro- and nano-technologies, keeping its potential benefits out-of-reach in many practical scenarios and devices. In this context, single-pixel techniques are a promising alternative to imaging arrays, in particular when targeting subwavelength resolutions. In this work, we discuss the key advantages and practical challenges in the implementation of time-resolved nonlinear ghost imaging (TIMING), an imaging technique combining nonlinear THz generation with time-resolved time-domain spectroscopy detection. We numerically demonstrate the high-resolution reconstruction of semi-transparent samples, and we show how the Walsh–Hadamard reconstruction scheme can be optimised to significantly reduce the reconstruction time. We also discuss how, in sharp contrast with traditional intensity-based ghost imaging, the field detection at the heart of TIMING enables high-fidelity image reconstruction via low numerical-aperture detection. Even more striking—and to the best of our knowledge, an issue never tackled before—the general concept of “resolution” of the imaging system as the “smallest feature discernible” appears to be not well suited to describing the fidelity limits of nonlinear ghost-imaging systems. Our results suggest that the drop in reconstruction accuracy stemming from non-ideal detection conditions is complex and not driven by the attenuation of high-frequency spatial components (i.e., blurring) as in standard imaging. On the technological side, we further show how achieving efficient optical-to-terahertz conversion in extremely short propagation lengths is crucial regarding imaging performance, and we propose low-bandgap semiconductors as a practical framework to obtain THz emission from quasi-2D structures, i.e., structure in which the interaction occurs on a deeply subwavelength scale. Our results establish a comprehensive theoretical and experimental framework for the development of a new generation of terahertz hyperspectral imaging devices

Turing patterns in a fiber laser with a nested microresonator: robust and controllable microcomb generation

Microcombs based on Turing patterns have been extensively studied in configurations that can be modelled by the Lugiato-Lefever equation. Typically, such schemes are implemented experimentally by resonant coupling of a continuous wave laser to a Kerr microcavity in order to generate highly coherent and robust waves. Here, we study the formation of such patterns in a system composed of a microresonator nested in an amplifying laser cavity, a scheme recently used to demonstrate laser cavity solitons with high optical efficiency and easy repetition rate control. Utilizing this concept, we study different regimes of Turing patterns, unveiling their formation dynamics and demonstrating their controllability and robustness. By conducting a comprehensive modulational instability study with a mean-field model of the system, we explain the pattern formation in terms of its evolution from background noise, paving the way towards complete self-starting operation. Our theoretical and experimental paper provides a clear pathway for repetition rate control of these waves over both fine (Megahertz) and large (Gigahertz) scales, featuring a fractional frequency nonuniformity better than 7 × 10−14 with a 100-ms time gate and without the need for active stabilization

Time-resolved nonlinear ghost imaging

EMBARGOED - expected end date 05.05.202

Concurrent terahertz generation via quantum interference in a quadratic media

The strive for efficiency in the generation of terahertz (THz) waves motivates intense research on novel field–matter interactions. Presently, THz generation via quadratic crystals remains the benchmark thanks to its simple and practical deployment. An interesting problem is whether new mechanisms can be exploited to elicit novel generation approaches and forms of control on the THz output in existing systems. THz generation via quantum interference (QI) leverages a third-order nonlinear response under resonant absorption, and it has been recently explored to access surface generation in centrosymmetric systems. Its deployment in standard THz quadratic sources can potentially create a physical setting with the concurrence of two different mechanisms. Here, THz generation via QI in noncentrosymmetric crystals concurrent with phase-matched quadratic generation in a bulk-transmission setting is demonstrated. Beyond investigating a new physical setting, it is demonstrated that conversion efficiencies much larger than those typically associated with the medium become accessible for a typically adopted crystal, ZnTe. An inherent control on the relative amplitude and sign of the two generated THz components is also achieved. This approach provides disruptive boost and management of the optical-to-THz conversion performance of a well-established technology, with significant ramifications in emerging spectroscopy and imaging applications. </p

Dataset for Concurrent terahertz generation via quantum interference in a quadratic media

Dataset to accompany the paper    "Concurrent terahertz generation via quantum interference in a quadratic media." The dataset is provided in a .fig format which contains the figures for the paper. The file format also contains the datasets for each of the figures.</p

Terahertz nonlinear ghost imaging via plane decomposition: Towards near-field micro-volumetry: Fig.2. US temporal movie

 Terahertz time-domain imaging targets the reconstruction of the full electromagnetic morphology of an object. In this spectral range, the near-field propagation strongly affects the information in the space-time domain in items with microscopic features. While this often represents a challenge, as the information needs to be disentangled to obtain high image fidelity, here we show that such a phenomenon can enable three-dimensional microscopy. Specifically, we investigate the capability of the time-resolved nonlinear ghost imaging (TNGI) methodology to implement field-sensitive micro-volumetry by plane decomposition. We leverage the temporally-resolved, field-sensitive detection to ‘refocus’ an image plane at an arbitrary distance from the source, which defines the near-field condition, and within a microscopic sample. Since space-time coupling rapidly evolves and diffuses within subwavelength length scales, our technique can separate and discriminate the information originating from different planes at different depths. Our approach is particularly suitable for objects with sparse micrometric details. Building upon this principle, we demonstrate complex, time-domain volumetry resolving internal object planes with sub-wavelength resolution, discussing the range of applicability of our technique. </p