16 research outputs found
第16回千葉カルシウム代謝研究会
Gene ontology term enrichments for RNA-Seq data from differentiated TSC2 deletion cell lines and microarray data of patient SEGAs (related to Fig. 2f). (XLSX 27.7 kb
Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Pharmacogenetic profiling with Biochips: an innovative concept to improve the efficiency of clinical trials
The genome sequence of the eastern woodchuck (Marmota monax) - A preclinical animal model for chronic hepatitis B
The Eastern woodchuck (Marmota monax) has been extensively used in research of chronic hepatitis B and liver cancer because its infection with the woodchuck hepatitis virus closely resembles a human hepatitis B virus infection. Development of novel immunotherapeutic approaches requires genetic information on immune pathway genes in this animal model. The woodchuck genome was assembled with a combination of high-coverage whole-genome shotgun sequencing of Illumina paired-end, mate-pair libraries and fosmid pool sequencing. The result is a 2.63 Gigabase (Gb) assembly with a contig N50 of 74.5 kilobases (kb), scaffold N50 of 892 kb, and genome completeness of 99.2%. RNA sequencing (RNA-seq) from seven different tissues aided in the annotation of 30,873 protein-coding genes, which in turn encode 41,826 unique protein products. More than 90% of the genes have been functionally annotated, with 82% of them containing open reading frames. This genome sequence and its annotation will enable further research in chronic hepatitis B and hepatocellular carcinoma and contribute to the understanding of immunological responses in the woodchuck
Additional file 8: Table S5. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Gene set enrichment analysis of ribosome profiling data (related to Fig. 3d). (XLSX 11.1 kb
Additional file 2: Figure S2. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Loss of TSC2 triggers expression changes related to inflammatory response, metabolism, and neuronal function. (PDF 1.15 mb
Additional file 1: Figure S1. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Deregulated expression of neuronal and glial markers in the absence of TSC2. (PDF 2.73 mb
Additional file 10: Table S7. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
RNA-Seq and ribosome profiling data of differentiated TSC2 wild-type and homozygous deletion cell lines treated with mTOR inhibitors (related to Fig. 4). (XLSB 7.52 mb
Additional file 9: Table S6. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Gene ontology term enrichments for ribosome profiling data (related to Fig. 3f). (XLSX 11 kb
Additional file 11: Table S8. of Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Gene sets and associated genes that show after mTOR treatment a reversal of the change in expression detected in untreated TSC2 deletion cells (related to Fig. 4b). (XLSX 25.8 kb