1,241 research outputs found
On a poroviscoelastic model for cell crawling
In this paper a minimal, oneâdimensional, twoâphase, viscoelastic, reactive, flow model for a crawling cell is presented. Twoâphase models are used with a variety of constitutive assumptions in the literature to model cell motility. We use an upperâconvected Maxwell model and demonstrate that even the simplest of twoâphase, viscoelastic models displays features relevant to cell motility. We also show care must be exercised in choosing parameters for such models as a poor choice can lead to an illâposed problem. A stability analysis reveals that the initially stationary, spatially uniform strip of cytoplasm starts to crawl in response to a perturbation which breaks the symmetry of the network volume fraction or network stress. We also demonstrate numerically that there is a steady travellingâwave solution in which the crawling velocity has a bellâshaped dependence on adhesion strength, in agreement with biological observation
Implicit discrimination of basic facial expressions of positive/negative emotion in Fragile X Syndrome and Autism Spectrum Disorder
Fragile X syndrome (FXS) and autism spectrum disorders (ASD) are characterized by impaired social functioning. We examined the spontaneous discrimination of happy and disgusted facial expressions, from neutral faces, in individuals with FXS (n â=â 13, Mage â=â 19.70) and ASD (n â=â 15, Mage â=â 11.00) matched on adaptive behavior and verbal abilities measured by the Vineland Adaptive Behavior Scale. Eye gaze to the eyes and mouth of neutral faces was also measured. Results suggest individuals with FXS and ASD distinguish facial expressions spontaneously in the same way. Individuals with FXS looked significantly less at the eye region of neutral faces than individuals with ASD. These results provide insight into similarities and differences in face processing in two neurodevelopmental disorders noted for their similarities in social behavior
Cellular Responses of \u3ci\u3eCandida albicans\u3c/i\u3e to Phagocytosis and the Extracellular Activities of Neutrophils Are Critical to Counteract Carbohydrate Starvation, Oxidative and Nitrosative Stress
Neutrophils are key players during Candida albicans infection. However, the relative contributions of neutrophil activities to fungal clearance and the relative importance of the fungal responses that counteract these activities remain unclear. We studied the contributions of the intra- and extracellular antifungal activities of human neutrophils using diagnostic Green Fluorescent Protein (GFP)-marked C. albicans strains. We found that a carbohydrate starvation response, as indicated by upregulation of glyoxylate cycle genes, was only induced upon phagocytosis of the fungus. Similarly, the nitrosative stress response was only observed in internalised fungal cells. In contrast, the response to oxidative stress was observed in both phagocytosed and non-phagocytosed fungal cells, indicating that oxidative stress is imposed both intra- and extracellularly. We assessed the contributions of carbohydrate starvation, oxidative and nitrosative stress as antifungal activities by analysing the resistance to neutrophil killing of C. albicans mutants lacking key glyoxylate cycle, oxidative and nitrosative stress genes. We found that the glyoxylate cycle plays a crucial role in fungal resistance against neutrophils. The inability to respond to oxidative stress (in cells lacking superoxide dismutase 5 or glutathione reductase 2) renders C. albicans
susceptible to neutrophil killing, due to the accumulation of reactive oxygen species (ROS). We also show that neutrophilderived nitric oxide is crucial for the killing of C. albicans: a yhb1â/â mutant, unable to detoxify NON, was more susceptible to neutrophils, and this phenotype was rescued by the nitric oxide scavenger carboxy-PTIO. The stress responses of C. albicans to neutrophils are partially regulated via the stress regulator Hog1 since a hog1â/â mutant was clearly less resistant to neutrophils and unable to respond properly to neutrophil-derived attack. Our data indicate that an appropriate fungal response to all three antifungal activities, carbohydrate starvation, nitrosative stress and oxidative stress, is essential for full wild type resistance to neutrophils
Magnetotransport properties of a polarization-doped three-dimensional electron slab
We present evidence of strong Shubnikov-de-Haas magnetoresistance
oscillations in a polarization-doped degenerate three-dimensional electron slab
in an AlGaN semiconductor system. The degenerate free carriers
are generated by a novel technique by grading a polar alloy semiconductor with
spatially changing polarization. Analysis of the magnetotransport data enables
us to extract an effective mass of and a quantum
scattering time of . Analysis of scattering processes helps
us extract an alloy scattering parameter for the AlGaN material
system to be
Type IIA Moduli Stabilization
We demonstrate that flux compactifications of type IIA string theory can
classically stabilize all geometric moduli. For a particular orientifold
background, we explicitly construct an infinite family of supersymmetric vacua
with all moduli stabilized at arbitrarily large volume, weak coupling, and
small negative cosmological constant. We obtain these solutions from both
ten-dimensional and four-dimensional perspectives. For more general
backgrounds, we study the equations for supersymmetric vacua coming from the
effective superpotential and show that all geometric moduli can be stabilized
by fluxes. We comment on the resulting picture of statistics on the landscape
of vacua.Comment: 48 pages, 2 figures, LaTeX. v2: references added. v3: minor comments
& references adde
The Giant Inflaton
We investigate a new mechanism for realizing slow roll inflation in string
theory, based on the dynamics of p anti-D3 branes in a class of mildly warped
flux compactifications. Attracted to the bottom of a warped conifold throat,
the anti-branes then cluster due to a novel mechanism wherein the background
flux polarizes in an attempt to screen them. Once they are sufficiently close,
the M units of flux cause the anti-branes to expand into a fuzzy NS5-brane,
which for rather generic choices of p/M will unwrap around the geometry,
decaying into D3-branes via a classical process. We find that the effective
potential governing this evolution possesses several epochs that can
potentially support slow-roll inflation, provided the process can be arranged
to take place at a high enough energy scale, of about one or two orders of
magnitude below the Planck energy; this scale, however, lies just outside the
bounds of our approximations.Comment: 31 pages, 4 figures, LaTeX. v2: references added, typos fixe
Can filesharers be triggered by economic incentives? Results of an experiment
Illegal filesharing on the internet leads to considerable financial losses for artists and copyright owners as well as producers and sellers of music. Thus far, measures to contain this phenomenon have been rather restrictive. However, there are still a considerable number of illegal systems, and users are able to decide quite freely between legal and illegal downloads because the latter are still difficult to sanction. Recent economic approaches account for the improved bargaining position of users. They are based on the idea of revenue-splitting between professional sellers and peers. In order to test such an innovative business model, the study reported in this article carried out an experiment with 100 undergraduate students, forming five small peer-to-peer networks.The networks were confronted with different economic conditions.The results indicate that even experienced filesharers hold favourable attitudes towards revenue-splitting.They seem to be willing to adjust their behaviour to different economic conditions
Magnetic enhancement of CoZnFeO spinel oxide by mechanical milling
We report the magnetic properties of mechanically milled
CoZnFeO spinel oxide. After 24 hours milling of the
bulk sample, the XRD spectra show nanostructure with average particle size
20 nm. The as milled sample shows an enhancement in magnetization and
ordering temperature compared to the bulk sample. If the as milled sample is
annealed at different temperatures for the same duration, recrystallization
process occurs and approaches to the bulk structure on increasing the annealing
temperatures. The magnetization of the annealed samples first increases and
then decreases. At higher annealing temperature ( 1000C) the system
shows two coexisting magnetic phases {\it i.e.}, spin glass state and
ferrimagnetic state, similar to the as prepared bulk sample. The room
temperature M\"{o}ssbauer spectra of the as milled sample, annealed at
300C for different durations (upto 575 hours), suggest that the observed
change in magnetic behaviour is strongly related with cations redistribution
between tetrahedral (A) and octahedral (O) sites in the spinel structure. Apart
from the cation redistribution, we suggest that the enhancement of
magnetization and ordering temperature is related with the reduction of B site
spin canting and increase of strain induced anisotropic energy during
mechanical milling.Comment: 14 pages LaTeX, 10 ps figure
Simultaneous Magneto-Optical Trapping of Two Lithium Isotopes
We confine 4 10^8 fermionic 6Li atoms simultaneously with 9 10^9 bosonic 7Li
atoms in a magneto-optical trap based on an all-semiconductor laser system. We
optimize the two-isotope sample for sympathetic evaporative cooling. This is an
essential step towards the production of a quantum-degenerate gas of fermionic
lithium atoms.Comment: 4 pages, 3 figure
Enhanced Symmetries in Multiparameter Flux Vacua
We give a construction of type IIB flux vacua with discrete R-symmetries and
vanishing superpotential for hypersurfaces in weighted projective space with
any number of moduli. We find that the existence of such vacua for a given
space depends on properties of the modular group, and for Fermat models can be
determined solely by the weights of the projective space. The periods of the
geometry do not in general have arithmetic properties, but live in a vector
space whose properties are vital to the construction.Comment: 32 pages, LaTeX. v2: references adde
- âŠ