147 research outputs found
Grundwissen als Voraussetzung fĂŒr Reflexionen - am Beispiel des GauĂalgorithmus
Im Mathematikunterricht sollte Wert auf Reflexionen des Lerngegenstands und seiner inner- sowie auĂermathematischen Bedeutung gelegt werden. Sinnvolle Reflexionen können aber nur mit verfĂŒgbarem Grundwissen gelingen. Im Beitrag soll am Beispiel des GauĂalgorithmus ein konkreter Vorschlag unterbreitet werden, wie man ein solches Grundwissen unter verschiedenen Reflexionsperspektiven beschreiben kann - als erste AnnĂ€herung an das Thema im Rahmen einer Dissertation
1032 Prognostic impact of contrast-enhanced CMR early after acute ST-segment elevation myocardial infarction (STEMI) in a regional STEMI network
205 Late enhancement in contrast-enhanced cardiac MRI facilitates the characterization of different etiologies in non-ischemic myocardial disease
CMR ventriculometry for evaluation of ecg hypertrophy criteria in a preventive medicine population
Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis
BACKGROUND: The diagnosis of myocarditis is challenging due to its varying clinical presentation. Since myocarditis can be associated with significant 5-year mortality, and postmortem data show myocarditis in almost 10% of all adults suffering sudden cardiac death, individual risk stratification for patients with suspected myocarditis is of great clinical interest. We sought to demonstrate that patients with clinically suspected myocarditis and a normal cardiovascular magnetic resonance (CMR) according to our definition have a good prognosis, independent of their clinical symptoms and other findings. METHODS: Prospective clinical long-term follow-up of consecutive patients undergoing CMR for work-up of clinically suspected myocarditis at our institution in 2007-2008. RESULTS: Follow-up was available for nâ=â405 patients (all-comers, 54.8% inpatients, 38% outpatient referrals from cardiologists). Median follow-up time was 1591 days. CMR diagnosis was âmyocarditisâ in 28.8%, ânormalâ in 55.6% and âother pathologyâ in 15.6%. Normal CMR was defined as normal left ventricular (LV) volumes and normal left ventricular ejection fraction (LV-EF) in the absence of late Gadolinium Enhancement (LGE). The overall mortality was 3.2%. There were seven cardiac deaths during follow-up, in addition one aborted SCD and two patients had appropriate internal cardioverter defibrillator (ICD) shocks â all of these occurred in patients with abnormal CMR. Kaplan-Meier analysis with log-rank test showed significant difference for major adverse cardiac events (cardiac death, sudden cardiac death (SCD), ICD discharge, aborted SCD) between patients with normal and abnormal CMR (pâ=â0.0003). CONCLUSION: In our unselected population of consecutive patients referred for CMR work-up of clinically suspected myocarditis, patients with normal CMR have a good prognosis independent of their clinical symptoms and other findings
Colorectal cancer testing rates after implementation of an organised screening programme in Vaud, Switzerland
AIMS OF THE STUDY: Canton Vaud, Switzerland, implemented an organised colorectal cancer  screening programme with colonoscopy and faecal occult blood tests in 2015, 4 to 6 years ahead of neighbouring cantons. Before its implementation, nearly half of Swiss citizens were already up to date with screening, primarily from opportunistic colonoscopies. We hypothesised that earlier implementation of an organised programme would be associated with greater increases in colorectal cancer testing rates.
METHODS: We analysed Swiss health insurance claim data from CSS, a Swiss health insurer covering 16% of the Swiss population and 10% of canton Vaud. We stratified 50â69-year-olds into groups from Vaud, its four neighbouring cantons (Fribourg, Geneva, NeuchĂątel and Valais), and the rest of Switzerland. We analysed overall, faecal occult blood test and colonoscopy testing rates for each year between 2010 and 2018.
RESULTS: The overall testing rate increased from 7.6% in 2010 to 11.6% in 2018 (+4.0%) in Vaud, from 6.1% to 9.3% (+3.2%) in neighbouring cantons and from 7.4% to 8.6% (+1.2%) in the rest of Switzerland. The faecal occult blood test rate increased between 2016 and 2018 from 2.9% to 4.1% (+1.2%) in Vaud and from 1.7% to 2.6% (+0.9%) in neighbouring cantons, but it decreased from 3.1% to 1.5% (â1.6%) in the rest of Switzerland. The colonoscopy rate increased in all cantons, from 4.7% to 7.5% in Vaud (+2.8%), from 4.4% to 6.7% in neighbouring cantons (+2.3%) and from 4.3% to 7.1% in the rest of Switzerland (+2.8%). By 2018, 40% of faecal occult blood tests and 26% of colonoscopies in Vaud occurred in the organised programme. Those who completed an faecal occult blood test within the Vaud programme were younger, had fewer comorbidities and were more likely to have a high-deductible health plan than those tested outside the programme.
CONCLUSIONS: Colorectal cancer testing rates increased between 2010 and 2018, with greater absolute increases in Vaud than in neighbouring cantons or the rest of Switzerland. Faecal occult blood test use increased in both Vaud and neighbouring cantons, possibly reflecting changes in testing patterns by general practitioners. By 2018, 40% of colonoscopies and 26% of faecal occult blood tests occurred within the screening programme
2079 Late gadolinium enhancement of the right ventricle â a substrate of different pathologies in contrast-enhanced cardiac MRI
Dislocation toughening in singleâcrystal KNbOâ
The growing research interest in dislocationâtuned functionality in ceramics is evident, with the most recent proofsâofâconcept for enhanced ferroelectric properties, electrical conductivity, and superconductivity via dislocations. In this work, we focus on dislocationâtuned mechanical properties and demonstrate that, by engineering high dislocation densities (up to 10Âč⎠mâ»ÂČ) into KNbOâ at room temperature, the fracture toughness can be improved by a factor of 2.8. The microstructures, including dislocations and domain walls, are examined by optical microscopy, electron channeling contrast imaging, piezoâresponse force microscopy, and transmission electron microscopy methods to shed light on the toughening mechanisms. In addition, highâtemperature (above the Curie temperature of KNbOâ) indentation tests were performed to exclude the influence of ferroelastic toughening, such that the origin of the toughening effect is pinpointed to be dislocations
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