Wasserstein-distance-based temporal clustering for capacity-expansion planning in power systems

As variable renewable energy sources are steadily incorporated in European power systems, the need for higher temporal resolution in capacity-expansion models also increases.Naturally, there exists a trade-off between the amount of temporal data used to plan power systems for decades ahead and time resolution needed to represent renewable energy variability accurately. We propose the use of the Wasserstein distance as a measure of cluster discrepancy using it to cluster demand, wind availability, and solar availability data. When compared to the Euclidean distance and the maximal distance, the hierarchical clustering performed using the Wasserstein distance leads to capacity-expansion planning that 1) more accurately estimates system costs and 2) more efficiently adopts storage resources. Numerical results indicate an improvement in cost estimation by up to 5% vis-à-vis the Euclidean distance and a reduction of storage investment that is equivalent to nearly 100% of the installed capacity under the benchmark full time resolution

Thorotrast Related Hepatic Malignancies. Two Case Reports

Os A.A apresentam dois casos clínicos de tumores hepáticos associados ao torotraste, dois colangiocarcinomas, observados numa enfermaria de Medicina Interna de um hospital de Lisboa. É feito um comentário sobre o efeito nefasto das radiações ionizantes em geral sobre o organismo humano, particularizando os efeitos do torotraste. Comenta-se, ainda, o prolongado tempo de latência que existiu nestes dois casos, bem como o facto de, provavelmente, estarmos perante os últimos casos de tumores induzidos pelo torotraste

Análise da postura cranio-cervical em pacientes com disfunção temporomandibular

OBJECTIVE: To compare head positioning and cervical spine alignment between individuals with and without temporomandibular disorders (TMDs), by means of positional evaluation using photographs, radiographs and visual observation, and to investigate whether the type of TMD influences head posture and cervical spine positioning. METHODS: Ninety randomly chosen women were diagnosed using the research diagnostic criteria for TMDs (RDC/TMD) by a trained examiner and were divided into three groups: Group 1, with a diagnosis of myofascial dysfunction (group I of RDC axis I); Group 2, with mixed TMD (groups I, II and III of RDC axis I); and Control, without TMD. Following this, the participants were photographed in frontal and lateral views by a single examiner. To produce these photos, the following anatomical points were marked out on the skin: occipital protuberance, C4, C7, acromioclavicular joint and sternoclavicular joint. From these points, different angles were analyzed by means of the ALCimagem-2000 application. These same photos were then evaluated qualitatively (visual evaluation). Next, lateral teleradiography and radiography of the cervical spine was requested. The examiner was blind when analyzing the images. To compare the results, the chi-squared test and analysis of variance were used, with significance levels of 5%. RESULTS: Regardless of the method used, the results revealed that head and cervical spine posture did not differ between the groups with and without TMD, independent of the diagnostic group. CONCLUSION: The posture of individuals with myogenic or arthrogenous TMD does not differ from the posture of individuals without TMD. The presence of TMD does not influence the head and cervical spine posture.OBJETIVO: Comparar o posicionamento da cabeça e o alinhamento da coluna cervical em indivíduos com e sem DTM, por meio da avaliação postural por fotografias, radiografias e por observação visual e verificar se o tipo de DTM influencia na postura da cabeça e no posicionamento da coluna cervical. MÉTODOS: Noventa mulheres escolhidas aleatoriamente foram diagnosticadas por meio dos Critérios para Diagnóstico em Pesquisa para Disfunções Temporomandibulares (RDC/TMD) por um examinador treinado e divididas em três grupos: grupo 1, diagnóstico de disfunção miofascial (grupo I do eixo I do RDC); grupo 2, com DTM mista (grupo I, II e III do eixo I do RDC) e controle, sem DTM . Em seguida, foram fotografadas em vista anterior e em perfil por um único examinador. Para a realização dessas fotografias, foram demarcados sobre a pele os seguintes pontos anatômicos: protuberância occiptal, C4, C7, articulação acromioclavicular e esternoclavicular. A partir desses pontos, foram analisados diferentes ângulos por meio do aplicativo ALCimagem-2000. Essas mesmas fotos foram posteriormente avaliadas qualitativamente (avaliação visual). Em seguida, foi solicitada uma radiografia e uma telerradiografia em perfil. O examinador foi cego ao analisar as imagens. Para comparação dos resultados, foi utilizado o teste qui-quadrado e a análise de variância com nível de significância de 5%. RESULTADOS: Independentemente do método utilizado, os resultados revelaram que a postura da cabeça e da coluna cervical não diferem entre o grupo com DTM e sem DTM, independentemente do grupo diagnosticado. CONCLUSÃO: A postura do indivíduo com DTM miogênica ou artrogênica não é diferente do indivíduo sem DTM. A presença da DTM não influencia na postura da cabeça e da coluna cervical

SAPHO: has the time come for tailored therapy?

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a heterogeneous condition combining osteoarticular and cutaneous manifestations. Conventional treatments are mostly ineffective. We hereby report two patients, the first with an aggressive form of disease and the second with an incomplete response to two different anti-TNF-α agents. Both were successfully treated with tocilizumab and ustekinumab, respectively, over a long period of time. A narrative review of a biological therapy in SAPHO syndrome yielded very little information on the specific use of these agents. We highlight the advantages of personalising therapy and describe emerging promising treatments for this disease.info:eu-repo/semantics/publishedVersio

Tribomechanical Comparison between PVA Hydrogels Obtained Using Different Processing Conditions and Human Cartilage

Designing materials for cartilage replacement raises several challenges due to the complexity of the natural tissue and its unique tribomechanical properties. Poly(vinyl alcohol) (PVA) hydrogels have been explored for such purpose since they are biocompatible, present high chemical stability, and their properties may be tailored through different strategies. In this work, the influence of preparation conditions of PVA hydrogels on its morphology, water absorption capacity, thermotropic behavior, mechanical properties, and tribological performance was evaluated and compared with those of human cartilage (HC). The hydrogels were obtained by cast-drying (CD) and freeze-thawing (FT), in various conditions. It was found that the method of preparation of the PVA hydrogels critically affects their microstructure and performance. CD gels presented a denser structure, absorbed less water, were stiffer, dissipated less energy, and withstood higher loads than FT gels. Moreover, they led to friction coefficients against stainless steel comparable with those of HC. Overall, CD hydrogels had a closer performance to natural HC, when compared to FT ones.info:eu-repo/semantics/publishedVersio

Comparative analysis between visual and computerized photogrammetry postural assessment

OBJETIVOS: Comparar a concordância interobservador da avaliação postural visual e por fotogrametria e verificar se os resultados quantitativos da fotogrametria correspondem à detecção de simetrias e assimetrias pela avaliação postural visual qualitativa. MÉTODOS: Vinte e um voluntários (24±1,9 anos) foram inicialmente avaliados visualmente por três fisioterapeutas experientes que preencheram um protocolo de avaliação postural. Em seguida tiveram fotografados a face e o corpo todo nos planos frontal anterior, posterior e sagital. As fotos foram utilizadas para traçar ângulos a partir de marcadores fixados à pele, em vários pontos anatômicos, que são referências frequentes na avaliação postural tradicional. Essas fotografias foram analisadas por três examinadores diferentes da avaliação postural visual. A concordância de cada método de avaliação postural foi avaliada pelos Coeficientes de Cramer V ou de PHI, considerando-se um nível de significância de 5%. RESULTADOS: Foi encontrada uma concordância entre os examinadores que utilizaram a fotogrametria para todos os segmentos avaliados. Não apresentaram concordância os segmentos comissura labial (p=0,00), acrômio clavicular (p=0,01), esternoclavicular (p=0,00), espinhas ilíacas anterior e posterior (p=0,00 e p=0,01) e ângulo inferior da escápula (p=0,00), que foram analizados por meio da avaliação postural visual. A comparação entre a fotogrametria e a avaliação postural visual demonstrou que o grau de concordância entre os dois métodos de avaliação foi pouco significativo para alguns segmentos do membro inferior e pelve. CONCLUSÕES: Nessas condições experimentais, os dados da fotogrametria não podem ser correlacionados com os dados da avaliação postural visual. A avaliação postural visual apresentou dados menos concordantes do que a fotogrametria, devendo ser questionada sua utilização como gold-standart.OBJECTIVES: To compare the interobserver agreement between visual and photogrammetry postural assessment and to determine whether the quantitative photogrammetry results correspond to the symmetries and asymmetries detected through qualitative visual postural assessment. METHODS: Twenty-one volunteers (mean age 24±1.9 years) were visually evaluated by three experienced physical therapists, who completed a postural assessment form. The participants' face and whole body were then photographed in the anterior and posterior frontal and sagittal planes. The photographs were used to draw angles from markers fixed to the skin at various anatomical points that are frequent references in traditional postural assessment. These photographs were analyzed by three examiners (other than the ones who performed the visual assessment). The agreement in each postural assessment method was determined using Cramer's V or the Phi coefficient, with the significance level set at 5%. RESULTS: There was agreement between the examiners who used photogrammetry, for all segments analyzed. No agreement was found for the labial commissure (p=0.00), acromioclavicular joint (p=0.01), sternoclavicular joint (p=0.00), anterior and posterior iliac spines (p=0.00 and p=0.01) or inferior angle of the scapula (p=0.00) when assessed visually. The comparison between photogrammetry and visual postural assessment showed that the agreement level between the two assessment methods was poor for some segments of the lower limb and pelvis. CONCLUSIONS: Under these experimental conditions, the photogrammetry data were not correlated with the results from the visual postural assessment. The visual postural assessment produced data that were in less agreement than the photogrammetry data, and its use as a gold standard must be questioned

Treatable Traits in COPD - A Proposed Approach

The well-recognized individual heterogeneity within COPD patients has led to a growing interest in greater personalization in the approach of these patients. Thus, the treatable traits strategy has been proposed as a further step towards precision medicine in the management of chronic airway disease, both in stable phase and acute exacerbations. The aim of this paper is to perform a critical review on the treatable traits strategy and propose a guide to approach COPD patients in the light of this new concept. An innovative stepwise approach is proposed - a multidisciplinary model based on two distinct phases, with the potential to be implemented in both primary care and hospital settings. The first phase is the initial and focused assessment of a selected subset of treatable traits, which should be addressed in all COPD patients in both settings (primary care and hospital). As some patients may present with advanced disease at diagnosis or may progress despite this initial treatment requiring a more specialized assessment, they should progress to a second phase, in which a broader approach is recommended. Beyond stable COPD, we explore how the treatable traits strategy may be applied to reduce the risk of future exacerbations and improve the management of COPD exacerbations. Since many treatable traits have already been related to exacerbation risk, the strategy proposed here represents an opportunity to be proactive. Although it still lacks prospective validation, we believe this is the way forward for the future of the COPD approach.info:eu-repo/semantics/publishedVersio

What Has Changed During the COVID-19 Pandemic? - The Effect on an Academic Breast Department in Portugal

Introduction: One year ago, Portugal entered its first lockdown because of the coronavirus disease-2019 (COVID-19) pandemic. The impact of this on delays in cancer diagnosis and treatment is a major concern, which may negatively affect the outcomes of these patients. Materials and methods: This retrospective, single-center analysis compared the clinical and pathological characteristics of breast cancer (BC) patients referred to a medical oncology first appointment between March 2020 and 2021, with the same period in the previous year. Results: Strikingly, there was a 40% reduction in the number of BC patients during lockdown. However, there was a statistically significant increase in the proportion of metastatic BC patients admitted for the first time for systemic therapy (13.6% vs. 28.9%, p = 0.003). Additionally, a statistically significant increase in the number of patients with bilateral early BC at diagnosis after March 2020 was found (7.2% vs. 1.9%, p = 0.043). Conclusion: These findings support international recommendations for an accelerated restoration of BC screening, to reduce incidence of advanced breast cancer at diagnosis and mitigate the expected impact of the COVID-19 pandemic on patients with cancer. Further work is needed to examine in detail the impact of measures to manage the COVID-19 pandemic on breast cancer outcomes.info:eu-repo/semantics/publishedVersio