39 research outputs found
Management of severe gastrointestinal tuberculosis with injectable antituberculous drugs
Get PDFAbstract: Abdominal tuberculosis (TB) is generally responsive to medical treatment, and early diagnosis and management can prevent unnecessary surgical intervention. However, intravenous therapy is needed for severe forms of tuberculosis with extensive gastrointestinal involvement. The authors report an immunocompetent patient with gastrointestinal TB who was successfully managed with a combination of surgical intervention and anti-TB medications, and discuss the importance of injectable anti-TB medications in the management of severe gastrointestinal TB. The present case report provides a model for assessment and intervention in severe forms of gastrointestinal TB
Outcomes of the first 54 pediatric patients on long-term home parenteral nutrition from a single Brazilian center
Get PDFObjectives: Data on multidisciplinary programs dedicated to home parenteral nutrition (HPN) in Latin America are limited. This study describes the results of the first multidisciplinary pediatric intestinal rehabilitation program for HPN at a public tertiary hospital in Brazil. Methods: We retrospectively reviewed patients aged 0–18 years with intestinal failure (IF) who required parenteral nutrition (PN) for >60 days between January/2014 and December/2020. Results: Fifty-four patients were discharged on HPN (15 achieved enteral autonomy, 34 continued on HPN at the end of the study, 1 underwent intestinal transplantation, and 4 died). The median (IQR) age at the study endpoint of patients who achieved enteral autonomy was 14.1 (9.7–19) versus 34.7 (20.4–53.9) months in those who did not achieve enteral autonomy. Overall prevalence of catheter-related thrombosis was 66.7% and catheterrelated bloodstream infection rate was 0.39/1000 catheter-days. Intestinal failure-associated liver disease (IFALD) was present in 24% of all patients; none of the patients who achieved enteral autonomy had IFALD. All patients showed significant improvement in anthropometric parameters during the HPN period. The sociodemographic characteristics of the patients’ family members were mothers less than 20 years old (7.5%), schooling time more than 10 years (55.5%), and household income between 1 and 3 times the minimum wage (64.8%). The 5-year survival rate for HPN is 90%, and 27.7% of patients achieve enteral autonomy. Conclusion: The treatment of pediatric patients with IF followed by a multidisciplinary pediatric intestinal rehabilitation program with HPN is feasible and safe in the Brazilian public health system
"Já que tu fazes psicologia, então..." : reflexões acerca da concepção cotidiana da psicologia
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Prevalência da infecção por cepas de helicobacter pylori cagA-positivo em crianças e adolescentes submetidos a esofagogastroduodenoscopia em Porto Alegre
Get PDFIntrodução: A infecção por Helicobacter pylori (H. pylori) tem distribuição geográfica universal, porém apresenta grande variabilidade na prevalência, nos fatores de virulência e na apresentação clínica de acordo com a população estudada. No Brasil, um país continental composto por etnias e hábitos culturais diversos, o comportamento da infecção também parece variar conforme já demonstrado em diferentes estudos. O presente estudo foi realizado com o objetivo de descrever a prevalência da infecção por cepas de H. pylori cagA-positivo em um grupo de crianças e adolescentes submetidos a esofagogastroduodenoscopia (EGD) em Porto Alegre, cidade situada na região Sul do Brasil. Materiais e Método: Noventa e oito fragmentos de biópsia gástrica de crianças e adolescentes foram submetidos à pesquisa de cepas de H. pylori cagA-positivo pelo método da reação em cadeia da polimerase (PCR). Resultados: A prevalência de cepas de H. pylori cagA-positivo foi de 29,6% (IC95% 18 a 43,6%). Não foram encontradas diferenças estatisticamente significativas quanto às características clínicas, demográficas, endoscópicas e histológicas dos pacientes infectados por cepas cagA-positivo em relação aos infectados por cepas cagA-negativo. Conclusões: O estudo demonstrou uma baixa prevalência da infecção por cepas de H. pylori cagA-positivo em crianças e adolescentes submetidos à EGD no sul do Brasil em comparação a estudos realizados com crianças de outras regiões do Brasil. Não houve associação entre a presença de cepas cagA-positivo e apresentação clínica adversa na amostra estudada.Introdution: Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. Objective: The present study aimed to describe the prevalence of infection with cagApositive H. pylori strains in a group of children and adolescents who underwent esophagogastroduodenoscopy (EGD) in Porto Alegre, a city in Southern Brazil. Methods: Ninety-eight gastric biopsy specimens of children and adolescents were tested for presence of H. pylori cagA-positive strains by the polymerase chain reaction (PCR) method. Results: The prevalence of H. pylori cagA-positive strains was 29.6% (IC95% from 18 to 43.6%). There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histological features of patients infected with cagA-positive strains as compared with those infected by cagA-negative strains. Conclusions: The study showed a low prevalence of infection with cagA-positive H. pylori strains among children and adolescents who underwent EGD in southern Brazil, in comparison to studies conducted with children from other regions of Brazil. There was no association between the presence of cagA-positive strains and more severe clinical presentations in the studied sample
Prevalência da infecção por cepas de helicobacter pylori cagA-positivo em crianças e adolescentes submetidos a esofagogastroduodenoscopia em Porto Alegre
Get PDFIntrodução: A infecção por Helicobacter pylori (H. pylori) tem distribuição geográfica universal, porém apresenta grande variabilidade na prevalência, nos fatores de virulência e na apresentação clínica de acordo com a população estudada. No Brasil, um país continental composto por etnias e hábitos culturais diversos, o comportamento da infecção também parece variar conforme já demonstrado em diferentes estudos. O presente estudo foi realizado com o objetivo de descrever a prevalência da infecção por cepas de H. pylori cagA-positivo em um grupo de crianças e adolescentes submetidos a esofagogastroduodenoscopia (EGD) em Porto Alegre, cidade situada na região Sul do Brasil. Materiais e Método: Noventa e oito fragmentos de biópsia gástrica de crianças e adolescentes foram submetidos à pesquisa de cepas de H. pylori cagA-positivo pelo método da reação em cadeia da polimerase (PCR). Resultados: A prevalência de cepas de H. pylori cagA-positivo foi de 29,6% (IC95% 18 a 43,6%). Não foram encontradas diferenças estatisticamente significativas quanto às características clínicas, demográficas, endoscópicas e histológicas dos pacientes infectados por cepas cagA-positivo em relação aos infectados por cepas cagA-negativo. Conclusões: O estudo demonstrou uma baixa prevalência da infecção por cepas de H. pylori cagA-positivo em crianças e adolescentes submetidos à EGD no sul do Brasil em comparação a estudos realizados com crianças de outras regiões do Brasil. Não houve associação entre a presença de cepas cagA-positivo e apresentação clínica adversa na amostra estudada.Introdution: Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. Objective: The present study aimed to describe the prevalence of infection with cagApositive H. pylori strains in a group of children and adolescents who underwent esophagogastroduodenoscopy (EGD) in Porto Alegre, a city in Southern Brazil. Methods: Ninety-eight gastric biopsy specimens of children and adolescents were tested for presence of H. pylori cagA-positive strains by the polymerase chain reaction (PCR) method. Results: The prevalence of H. pylori cagA-positive strains was 29.6% (IC95% from 18 to 43.6%). There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histological features of patients infected with cagA-positive strains as compared with those infected by cagA-negative strains. Conclusions: The study showed a low prevalence of infection with cagA-positive H. pylori strains among children and adolescents who underwent EGD in southern Brazil, in comparison to studies conducted with children from other regions of Brazil. There was no association between the presence of cagA-positive strains and more severe clinical presentations in the studied sample
