Thermospheric Heating and Cooling Times During Geomagnetic Storms, Including Extreme Events

We present the first quantitative calculations of thermospheric heating and cooling times for geomagnetic storms of different intensity, including extreme events. We utilize the neutral mass density database of the CHAllenging Minisatellite Payload and Gravity Recovery And Climate Experiment missions to produce thermospheric global system response to geomagnetic storms caused by coronal mass ejections via superposed epoch analysis during May 2001 to December 2015. Storm events are grouped in five different categories based on the minimum value of the SYMH index. We calculate the time from storm onset for the thermosphere to reach maximum intensification (heating time) and the time from onset for the thermosphere to recover (cooling time). We find that heating and cooling times decrease as storm intensity increases and the effect is more pronounced for the cooling times. For extreme storms, the thermospheric heating time is 9.5 hr, while the cooling time is 22 hr

Interplanetary Shock Data Base

In this manuscript, I provide an updated interplanetary shock data base I published in previous works. This list has now 603 events. I also present and describe the data and methodologies used to compile this list. The main contribution of this work is to provide an updated end accurate interplanetary shock data base for future space physics and space weather investigations. The list has been uploaded to Zenodo, and a link is provided for accessing the data files. As for Frontiers requirements, the access of the list has kept to be restricted during the review process. The list will be made public if/when the manuscript is published.Comment: 2 Figures, 2 Listings, 2 Table

The Extreme Space Weather Event in 1903 October/November: An Outburst from the Quiet Sun

While the Sun is generally more eruptive during its maximum and declining phases, observational evidence shows certain cases of powerful solar eruptions during the quiet phase of the solar activity. Occurring in the weak Solar Cycle 14 just after its minimum, the extreme space weather event in 1903 October -- November was one of these cases. Here, we reconstruct the time series of geomagnetic activity based on contemporary observational records. With the mid-latitude magnetograms, the 1903 magnetic storm is thought to be caused by a fast coronal mass ejection (~1500 km/s) and is regarded as an intense event with an estimated minimum Dst' of ~-513 nT The reconstructed time series has been compared with the equatorward extension of auroral oval (~44.1{\deg} in invariant latitude) and the time series of telegraphic disturbances. This case study shows that potential threats posed by extreme space weather events exist even during weak solar cycles or near their minima.Comment: 20 pages, 5 figures, 1 table, and accepted for publication in the ApJ

Furanoditerpenes from Pterodon pubescens benth with selective in vitro anticancer activity for prostate cell line

Activity guided fractionation of Pterodon pubescens Benth. methylene chloride-soluble fraction afforded novel 6α-acetoxi 7β-hydroxy-vouacapan 1 and four known diterpene furans 2, 3, 4, 5. The compounds were evaluated for in vitro cytotoxic activities against human normal cells and tumour cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung, non-small cells), OVCAR-03 (ovarian), PC-3 (prostate), HT-29 (colon), 786-0 (renal), K562 (leukemia) and NCI-ADR/RES (ovarian expressing phenotype multiple drugs resistance). Results were expressed by three concentration dependent parameters GI50 (concentration that produces 50% growth inhibition), TGI (concentration that produces total growth inhibition or cytostatic effect) and LC50 (concentration that produces -50% growth, a cytotoxicity parameter). Also, in vitro cytotoxicity was evaluated against 3T3 cell line (mouse embryonic fibroblasts). Antiproliferative properties of compounds 1, 4 and 5 are herein reported for the first time. These compounds showed selectivity in a concentration-dependent way against human PC-3. Compound 1 demonstrated selectivity 26 fold more potent than the positive control, doxorubicin, for PC-3 (prostrate) cell line based on GI50 values, causing cytostatic effect (TGI value) at a concentration fifteen times less than positive control. Moreover comparison of 50% lethal concentration (LC50 value) with positive control (doxorubicin) suggested that compound 1 was less toxic