Near-infrared K-band Spectroscopic Investigation of Seyfert 2 Nuclei in the CfA and 12 Micron Samples

We present near-infrared K-band slit spectra of the nuclei of 25 Seyfert 2 galaxies in the CfA and 12 micron samples. The strength of the CO absorption features at 2.3-2.4 micron produced by stars is measured in terms of a spectroscopic CO index. A clear anti-correlation between the observed CO index and the nuclear K-L color is present, suggesting that a featureless hot dust continuum heated by an AGN contributes significantly to the observed K-band fluxes in the nuclei of Seyfert 2 galaxies. After correction for this AGN contribution, we estimate nuclear stellar K-band luminosities for all sources, and CO indices for sources with modestly large observed CO indices. The corrected CO indices for 10 (=40%) Seyfert 2 nuclei are found to be as high as those observed in star-forming or elliptical (=spheroidal) galaxies. We combine the K-band data with measurements of the L-band 3.3 micron polycyclic aromatic hydrocarbon (PAH) emission feature, another powerful indicator for star-formation, and find that the 3.3 micron PAH to K-band stellar luminosity ratios are substantially smaller than those of starburst galaxies. Our results suggest that the 3.3 micron PAH emission originates in the putative nuclear starbursts in the dusty tori surrounding the AGNs, because of its high surface brightness, whereas the K-band CO absorption features detected at the nuclei are dominated by old bulge (=spheroid) stars, and thus may not be a powerful indicator for the nuclear starbursts. We see no clear difference in the strength of the CO absorption and PAH emission features between the CfA and 12 micron Seyfert 2s.Comment: 28 pages, 6 figures, accepted for publication in ApJ (10 October 2004, v614 issue

HIV-associated progressive multifocal leukoencephalopathy. Current perspectives

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, caused by the polyomavirus JC and occurring almost exclusively in the context of severe immune depression. AIDS represents the most common predisposing condition for PML development. Antiretroviral treatment has reduced PML incidence in HIV-infected subjects, but the disease remains a severe and life-threatening complication of AIDS, considering thus far the lack of an effective anti-JC virus (JCV) direct-acting antiviral drug. In the last decade, the use of monoclonal antibodies for treating immune-based diseases evidenced new predisposing conditions for PML development, promoting a renewed interest in PML pathogenesis. In this article, we review the current knowledge on JCV epidemiology and AIDS-associated PML incidence, JCV viral cycle, pathogenesis, and the interplay with HIV infection. We give an updated overview of diagnostic and prognostic tools available for PML diagnosis and describe past and current therapeutic approaches, including new strategies for PML cure

Mid-Infrared line diagnostics of Active Galaxies -- A spectroscopic AGN survey with ISO-SWS

We present medium resolution (R approx. 1500) ISO-SWS 2.4--45 micron spectra of a sample of 29 galaxies with active nuclei. This data set is rich in fine structure emission lines tracing the narrow line regions and (circum-)nuclear star formation regions, and it provides a coherent spectroscopic reference for future extragalactic studies in the mid-infrared. We use the data set to briefly discuss the physical conditions in the narrow line regions (density, temperature, excitation, line profiles) and to test for possible differences between AGN sub-types. Our main focus is on new tools for determining the propertibes of dusty galaxies and on the AGN-starburst connection. We present mid-IR line ratio diagrams which can be used to identify composite (starburst + AGN) sources and to distinguish between emission excited by active nuclei and emission from (circum-nuclear) star forming regions. For instance, line ratios of high to low excitation lines like [O IV]25.9um/[Ne II]12.8um, that have been used to probe for AGNs in dusty objects, can be examined in more detail and with better statistics now. In addition, we present two-dimensional diagnostic diagrams that are fully analogous to classical optical diagnostic diagrams, but better suited for objects with high extinction. Finally, we discuss correlations of mid-infrared line fluxes to the mid- and far-infrared continuum. We compare these relations to similar relations in starburst galaxies in order to examine the contribution of AGNs to the bolometric luminosities of their host galaxies. The spectra are available in electronic form from the authors.Comment: 24 pages, 23 figures, 5 tables. Accepted for A&