Endurance ratios of middle-distance race

The paper deals with the ergometric endurance criteria in field-and-track middle-distance race and systematizes the applied training means according to the direction (nature) of the physiological effect. The ergometric analysis of ‘velocity – time’ and ‘distance – time’ dependences, according to the data of the world race records, allows defining the role of the aerobic and anaerobic energy production at particular distances of the field-and-track race. The level of development of the sportsmen’s aerobic and anaerobic capacities affects the manifestation of special endurance in the middle-distance race. The experiment was conducted among field-and-track athletes of high qualification specializing in the middle (800 and 1500 m) distances. The main factor influencing the result in a race is the energy indicators. So, their measurement and estimate serve the main leverage of the training session. The use of predominantly anaerobic exercises during the specialized work-outs significantly improves the runners’ special endurance indicators

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice

Mitochondrial translation is a unique relic of the symbiotic origin of the organelle. Alterations of its components cause a number of severe human diseases. Hereby we report a study of mice devoid of Mettl15 mitochondrial 12S rRNA methyltransferase, responsible for the formation of m4C839 residue (human numbering). Homozygous Mettl15−/− mice appeared to be viable in contrast to other mitochondrial rRNA methyltransferase knockouts reported earlier. The phenotype of Mettl15−/− mice is much milder than that of other mutants of mitochondrial translation apparatus. In agreement with the results obtained earlier for cell cultures with an inactivated Mettl15 gene, we observed accumulation of the RbfA factor, normally associated with the precursor of the 28S subunit, in the 55S mitochondrial ribosome fraction of knockout mice. A lack of Mettl15 leads to a lower blood glucose level after physical exercise relative to that of the wild-type mice. Mettl15−/− mice demonstrated suboptimal muscle performance and lower levels of Cox3 protein synthesized by mitoribosomes in the oxidative soleus muscles. Additionally, we detected decreased learning capabilities in the Mettl15−/− knockout mice in the tests with both positive and negative reinforcement. Such properties make Mettl15−/− knockout mice a suitable model for mild mitochondriopathies