Cultural security of the transboundary in a globalizing world : a theoretical and methodological analysis

This article presents the phenomenon of cultural security on the basis of "systematic unity" and "typological differences". This allowed to analyze the features of the manifestation of cultural security in Russian and Chinese society on the example of religious security.peer-reviewe

New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided molecular design of new thrombin inhibitors was performed using our original docking program SOL, which is based on the genetic algorithm of global energy minimization in the framework of a Merck Molecular Force Field. This program takes into account the effects of solvent. The designed molecules with the best scoring functions (calculated binding energies) were synthesized and their thrombin inhibitory activity evaluated experimentally in vitro using a chromogenic substrate in a buffer system and using a thrombin generation test in isolated plasma and in vivo using the newly developed model of hemodilution-induced hypercoagulation in rats. The acute toxicities of the most promising new thrombin inhibitors were evaluated in mice, and their stabilities in aqueous solutions were measured. RESULTS: New compounds that are both effective direct thrombin inhibitors (the best K(I) was <1 nM) and strong anticoagulants in plasma (an IC(50) in the thrombin generation assay of approximately 100 nM) were discovered. These compounds contain one of the following new residues as the basic fragment: isothiuronium, 4-aminopyridinium, or 2-aminothiazolinium. LD(50) values for the best new inhibitors ranged from 166.7 to >1111.1 mg/kg. A plasma-substituting solution supplemented with one of the new inhibitors prevented hypercoagulation in the rat model of hemodilution-induced hypercoagulation. Activities of the best new inhibitors in physiological saline (1 µM solutions) were stable after sterilization by autoclaving, and the inhibitors remained stable at long-term storage over more than 1.5 years at room temperature and at 4°C. CONCLUSIONS: The high efficacy, stability and low acute toxicity reveal that the inhibitors that were developed may be promising for potential medical applications

Guadalajara's "bucaros" on Saint Petersbourg Museum

El presente ensayo se centra en la primera colección mexicana del Museo de antropología y etnografía de la Academia de Ciencias de Rusia (MAE ACR) en San Petersburgo. Dicha colección fue donada al museo en 1783 por la emperatriz rusa Catalina la Grande y consistió de las 20 piezas cerámicas procedentes de Guadalajara en el Virreinato de la Nueva España. Este tipo de cerámica se denomina Tonalá bruñida y se produce en México desde principios del siglo XVII hasta nuestros días. La investigación se basa en el estudio exhaustivo de las colecciones de Tonalá bruñida de varios museos como el Museo de América y el Museo Nacional de Artes Decorativos en Madrid, el Museo Palacio de la condesa de Lebrija en Sevilla, el Musée National de Céramique en Sevres, así como en el estudio de campo entre los ceramistas del centro alfarero Tonalá. El objetivo del ensayo es considerar la colección de MAE ACR en un contexto más amplio de otras colecciones europeas de cerámica de la época colonial en Tonalá.This paper focuses on the first Mexican collection in the Peter the Great Museum of Anthropology and Ethnography Russian Academy of Sciences (MAE RAS) in Saint Petersburg. The collection entered the Museum thanks to a donation made in 1783 by the Russian Empress Catherine the Great and consisted of 20 pieces of ceramics originating from the City of Guadalajara in New Spain. This type of ceramics is called Tonalá bruñida and produced in Mexico from the beginning of 17th century to the present day. The research is based on the comprehensive study of the Tonalá bruñida collections from various museums such as Museo de América and Museo Nacional de Artes Decorativos in Madrid, Museo Palacio de la condesa de Lebrija in Seville, Musée National de Céramique in Sevres, as well as on the field study among the ceramists from Tonala. The aim of the paper is to consider the MAE RAS collection in a broader context of other European ceramic collections from colonial time Tonala.Área de Historia del Arte. Universidad Pablo de Olavide, SevillaVersión del edito

COMPLEX PSIHOLOGO-PEDAGOGICAL CORRECTION OF CHILDREN WITH RDA – A NECESSARY CONDITION OF SUCCESSFUL INTEGRATION OF THE CHILD IN SOCIETY

In article on the basis of the analysis of modern researches of a problem of early children's autism correctional work with the autichny child is presented. The structure of psikhologo-pedagogical process of correction of children with early children's autism is described. Purpose: to present system of complex psikhologo-pedagogical correction of children with RDA as a necessary condition of their integration into society. Method or methodology of carrying out work: methodology of pedagogical research Results: the system of complex psikhologo-pedagogical correction of children offered by the author with RDA can be introduced in system of vocational (correctional) education, as passed approbation within work of the Regional center of diagnostics and correction. Scope of results: practice of modern vocational (correctional) education

Production of Platinum Atom Nanoclusters at One End of Helical Plant Viruses

Platinum atom clusters (Pt nanoparticles, Pt-NPs) were produced selectively at one end of helical plant viruses, tobacco mosaic virus (TMV) and potato virus X (PVX), when platinum coordinate compounds were reduced chemically by borohydrides. Size of the platinum NPs depends on conditions of the electroless deposition of platinum atoms on the virus. Results suggest that the Pt-NPs are bound concurrently to the terminal protein subunits and the 5′ end of encapsidated TMV RNA. Thus, a special structure of tobacco mosaic virus and potato X virus particles with nanoparticles of platinum, which looks like a push-pin with platinum head and virus needle, was obtained. Similar results were obtained with ultrasonically fragmented TMV particles. By contrast, the Pt-NPs fully filled the central axial hole of in vitro assembled RNA-free TMV-like particles. We believe that the results presented here will be valuable in the fundamental understanding of interaction of viral platforms with ionic metals and in a mechanism of nanoparticles formation

The study of the nature of the inheritance of quantitative traits in F

In the conditions of the south of the Nonchernozem Zone, intraspecific hybridization of winter soft wheat was carried out. When selecting parental forms used in crossing, special attention was paid to such economically valuable traits as productive tilling capacity, the number of grains and the mass of grain per spike. The true (Htru) and hypothetical heterosis (Hhyp) on the basis of “plant height”, “length of the lower internode”, “length of the upper internode”, “general tilling capacity”, “productive tilling capacity”, “spike length”, “number of spikelets”, “number of grains” and “grain weight per spike” were determined. It was established that the inheritance of quantitative traits in hybrids of the first generation was distinguished by the complex nature of distribution by types. Studies have made possible to identify 5 hybrid combinations F1, in which the effect of heterosis manifests itself simultaneously on five quantitative characteristics (ear length, number of spikelets per ear, number of grains per ear, grain weight per ear, mass grain from a plant)

Problems of economic globalization of China as a factor of cultural security

The article is devoted to the analysis of the problems of economic globalization in China and as a factor of cultural security. A philosophical analysis of the social aspect of China’s regional development. J. Sigurdson, like many researchers, analyzes economic, political factors, technological innovations, regional development programs of China. Our attention was drawn to the fact that he is one of the few Western researchers who analyze social problems. J. Sigurdson gives an analysis of Chinese society in the context of the development of technological systems. He notes that the creation of clusters, the use of new technologies contribute to the development of the social infrastructure of modern Chinese society. It is worth noting that his analysis is based on the historical information approach. In this case, we are not interested in ascertaining the facts presented by him, but in describing the role of innovation systems in the development of the social sphere of Chinese society. Thus, the relevance of this article is due to the need to analyze Western research on the social factor of regional changes in China. The entry into globalization processes and the perception of the economic opportunities of the modern world in China is refracted through traditional culture and allows not only to preserve its own values, but also to successfully adapt them to the realities of the present day on one hand and spread it outside on the other. China plays an important role in the modern economic development of the world. The main task of the Chinese strategy for the development of clusters was to ensure that the results met not only the economic development of the country, but also the rise of the social, cultural component. The Chinese government is aware of the depth of existing problems in society, and how we see new promising plans for the development of China’s economic system. In the artical, we allows us to view modern China not only as a simple element of the world economic system, but rather as one of the leading subjects of economic globalization, actively participating in the world economy and making a significant contribution to the development of the modern world. In our view, it is the integrity of the domestic political and foreign policy course of the country’s development that allowed the Chinese economy and culture to become a visible and important element of the world economy

Problems of economic globalization of China as a factor of cultural security

The article is devoted to the analysis of the problems of economic globalization in China and as a factor of cultural security. A philosophical analysis of the social aspect of China’s regional development. J. Sigurdson, like many researchers, analyzes economic, political factors, technological innovations, regional development programs of China. Our attention was drawn to the fact that he is one of the few Western researchers who analyze social problems. J. Sigurdson gives an analysis of Chinese society in the context of the development of technological systems. He notes that the creation of clusters, the use of new technologies contribute to the development of the social infrastructure of modern Chinese society. It is worth noting that his analysis is based on the historical information approach. In this case, we are not interested in ascertaining the facts presented by him, but in describing the role of innovation systems in the development of the social sphere of Chinese society. Thus, the relevance of this article is due to the need to analyze Western research on the social factor of regional changes in China. The entry into globalization processes and the perception of the economic opportunities of the modern world in China is refracted through traditional culture and allows not only to preserve its own values, but also to successfully adapt them to the realities of the present day on one hand and spread it outside on the other. China plays an important role in the modern economic development of the world. The main task of the Chinese strategy for the development of clusters was to ensure that the results met not only the economic development of the country, but also the rise of the social, cultural component. The Chinese government is aware of the depth of existing problems in society, and how we see new promising plans for the development of China’s economic system. In the artical, we allows us to view modern China not only as a simple element of the world economic system, but rather as one of the leading subjects of economic globalization, actively participating in the world economy and making a significant contribution to the development of the modern world. In our view, it is the integrity of the domestic political and foreign policy course of the country’s development that allowed the Chinese economy and culture to become a visible and important element of the world economy

Plant Viruses as Adjuvants for Next-Generation Vaccines and Immunotherapy

Vaccines are the cornerstone of infectious disease control and prevention. The outbreak of SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel vaccines. Plant viruses and their derivatives are being used increasingly for the development of new medical and biotechnological applications, and this is reflected in a number of preclinical and clinical studies. Plant viruses have a unique combination of features (biosafety, low reactogenicity, inexpensiveness and ease of production, etc.), which determine their potential. This review presents the latest data on the use of plant viruses with different types of symmetry as vaccine components and adjuvants in cancer immunotherapy. The discussion concludes that the most promising approaches might be those that use structurally modified plant viruses (spherical particles) obtained from the Tobacco mosaic virus. These particles combine high adsorption properties (as a carrier) with strong immunogenicity, as has been confirmed using various antigens in animal models. According to current research, it is evident that plant viruses have great potential for application in the development of vaccines and in cancer immunotherapy

Gene Polymorphism of Biotransformation Enzymes and Ciprofloxacin Pharmacokinetics in Pediatric Patients with Cystic Fibrosis

(1) Background: Ciprofloxacin (CPF) is widely used for the treatment of cystic fibrosis, including pediatric patients, but its pharmacokinetics is poorly studied in this population. Optimal CPF dosing in pediatric patients may be affected by gene polymorphism of the enzymes involved in its biotransformation. (2) Materials and Methods: a two-center prospective non-randomized study of CPF pharmacokinetics with sequential enrollment of patients (n-33, mean age 9.03 years, male-33.36%), over a period from 2016 to 2021. All patients received tablets of the original CPF drug Cyprobay&reg; at a dose of 16.5 mg/kg to 28.80 mg/kg. Blood sampling schedule: 0 (before taking the drug), 1.5 h; 3.0 h; 4.5 h; 6.0 h; 7.5 h after the first dosing. CPF serum concentrations were analyzed by high performance liquid chromatography mass spectrometry. The genotype of biotransformation enzymes was studied using total DNA isolated from whole blood leukocytes by the standard method. (4) Results: a possible relationship between the CA genotype of the CYP2C9 gene (c.1075A &gt; C), the GG genotype of the CYP2D6*4 gene (1846G &gt; A), the AG genotype of the GSTP1 gene (c.313A &gt; G), the GCLC* genotype 7/7 and the CPF concentration in plasma (increased value of the area under the concentration&ndash;time curve) was established. Conclusions: Gene polymorphism of biotransformation enzymes may affect ciprofloxacin pharmacokinetics in children