The Dipole Magnet Design for the ALICE DiMuon Arm Spectrometer

An essential part of the DiMuon Arm Spectrometer of the ALICE experiment is a conventional Dipole Magnet of about 890 tons which provides the bending power to measure the momenta of muons. The JINR engineering design of the Dipole Magnet, technical characteristics and description of the proposed manufacturing procedure are presented. The proposed Coil fabrication technique is based on winding of flat pancakes, which are subsequently bent on cylindrical mandrels. The pancakes are then stacked and cured with prepreg insulation. The method is demonstrated on hand of the prototype II, which consists of a pancake made with full-size aluminium conductor. Some details of electromagnetic and mechanical calculations are described. The results of measuring of mechanical and electrical characteristics of materials related to the coil composite structure are discussed

Accelerating functional gene discovery in osteoarthritis

Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression. Here, we develop, validate and use rapid-throughput imaging techniques to identify abnormal joint phenotypes in randomly selected mutant mice generated by the International Knockout Mouse Consortium. We identify 14 genes with functional involvement in osteoarthritis pathogenesis, including the homeobox gene Pitx1, and functionally characterize 6 candidate human osteoarthritis genes in mouse models. We demonstrate sensitivity of the methods by identifying age-related degenerative joint damage in wild-type mice. Finally, we phenotype previously generated mutant mice with an osteoarthritis-associated polymorphism in the Dio2 gene by CRISPR/Cas9 genome editing and demonstrate a protective role in disease onset with public health implications. We hope this expanding resource of mutant mice will accelerate functional gene discovery in osteoarthritis and offer drug discovery opportunities for this common, incapacitating chronic disease

The dipole magnet iron yoke design for the ALICE Dimuon Arm Spectrometer

Iron Yoke of about 820 tons for the Dipole Magnet with aluminium water cooledwinding has been produced for the DiMuon Arm Spectrometer of ALICE experiment atthe LHC. This magnet provides the bending power to measure the momenta of muons.The initial design of the magnet was prepared by JINR. The main feature of thismagnet is the huge uncompensated force applied from the neighbouring solenoidmagnet L3. The yoke of the magnet was manufactured and preliminary assembled inRussia in Tver region at SMZ manufacturing company and transported to CERN. Theresults of electromagnetic forces calculations and deflected mode analysis arepresented. Design, following up of the yoke production and the main features ofthe technology process are discussed