Acid-Base Resistant Zone in Teeth with the Direct Restoration Using Different Adhesive System Generations: A Systematic Review

Objective: To find out what the acid-base resistant zone (ABRZ) is and the mechanism of its formation. Material and Methods: This systematic review was based on the search of laboratory studies in which self-etching adhesive systems were used. The electronic database PubMed was used for the search. The search began on August 2021 and ended on June 2022. We have analyzed the materials and methods of each research and entered them in the appropriate tables to give a clearer assessment of the obtained results. Results: This systematic review included 15 full-text articles published from 2011 to 2019. The ABRZ is formed on both dentine and enamel. On dentine, the ABRZ is formed only when using self-etching adhesive systems; on the enamel, on the contrary, the step of preliminary etch and rinse contributes to the formation of a thicker ABRZ. The functional monomer MDP and fluorine increase the thickness of the ABRZ and provide a hybrid layer /ABRZ boundary without defects and erosions. Conclusion: Self-etching adhesive systems ensure the creation of an ABRZ resistant to acid-base tests. This phenomenon can provide the resistance of tooth tissues to demineralization, and therefore increase their resistance to caries

Acid-Base Resistant Zone in Teeth with the Direct Restoration Using Different Adhesive System Generations: A Systematic Review

Objective: To find out what the acid-base resistant zone (ABRZ) is and the mechanism of its formation. Material and Methods: This systematic review was based on the search of laboratory studies in which self-etching adhesive systems were used. The electronic database PubMed was used for the search. The search began on August 2021 and ended on June 2022. We have analyzed the materials and methods of each research and entered them in the appropriate tables to give a clearer assessment of the obtained results. Results: This systematic review included 15 full-text articles published from 2011 to 2019. The ABRZ is formed on both dentine and enamel. On dentine, the ABRZ is formed only when using self-etching adhesive systems; on the enamel, on the contrary, the step of preliminary etch and rinse contributes to the formation of a thicker ABRZ. The functional monomer MDP and fluorine increase the thickness of the ABRZ and provide a hybrid layer /ABRZ boundary without defects and erosions. Conclusion: Self-etching adhesive systems ensure the creation of an ABRZ resistant to acid-base tests. This phenomenon can provide the resistance of tooth tissues to demineralization, and therefore increase their resistance to caries

Canalis Sinuosus Damage after Immediate Dental Implant Placement in the Esthetic Zone

Dental implant failure in the anterior maxilla can be caused by the range of the features. One of them is neighboring neurovascular structure damage, such as the canalis sinuosus (CS), that carries the superior anterior alveolar nerve. The aim of the report is to demonstrate clinical symptomatology and radiographic signs of CS damage in a 45-year-old female patient who underwent upper left lateral incisor extraction and immediate implant placement and implant removal in 16 days secondary to pain and paresthesia in the maxillary left region

The Placement of Four Short Implants and Full-Arch Early Loading in the Edentulous Patient Suffering from Severe Mandibular Alveolar Ridge Atrophy

One of the treatments of patients with severe bone atrophy is short implants. It is important to position short implants taking into account the prosthetic loading and right position according to vital anatomical structures. In the presented case report, a seventy-one-year-old female patient underwent the rehabilitation with four short dental implants placed in the anterior mandibula with fully guided surgery to avoid mandibular incisive canal. It solves all the problems in the planning stage when you determine the osteotomy protocol in advance and the prognosis of future restoration according to patient requirements. This clinical case demonstrates the efficiency of patient rehabilitation with the use of short implants in difficult clinical situations

Immediate Autogenous Extracted Tooth as a Grafting Material For Fresh Socket Preservation: a Systematic Review

Objectives: To evaluate the use of extracted autogenous teeth for socket preservation after tooth extraction. Material and Methods: Cochrane, Scopus, and PubMed databases search was conducted to identify human clinical studies reporting the clinical, radiographic and/or histological outcomes of socket preservation techniques with autogenous extracted tooth Only studies published in English language in the last 10 years were included in the study. Results:In total, 82 articles were identified. Five articles were included in the review. They included 58 teeth that were prepared as a graft for socket preservation. The grafts derived from autogenous teeth were presented in three forms: particles, blocks and powder. The mean bone loss ranged from 0.28 mm to 0.41mm in height and 0.15 mm in width.Conclusion: Immediate autogenous extracted tooth as a grafting material for fresh socket preservation is promising for future daily clinical practice. More clinical comparative studies are needed.Objetivo: Evaluar el uso de dientes extraídos autógenos para la preservación del alveolo tras la extracción dental.Material y Métodos: Se realizó una búsqueda en las bases de datos Cochrane, Scopus y PubMed para identificar estudios clínicos en humanos que informaban los resultados clínicos, radiográficos y / o histológicos de las técnicas de preservación de alveolos con dientes extraídos autógenos. Solo se incluyeron estudios publicados en inglés en los últimos 10 años. Resultados: En total se identificaron 82 artículos. Se incluyeron cinco artículos en la revisión. Incluyeron 58 dientes que se prepararon como injerto para la preservación del alveolo. Los injertos derivados de dientes autógenos se presentaron en tres formas: partículas, bloques y polvo. La pérdida ósea media osciló entre 0,28 mm y 0,41 mm de altura y 0,15 mm de ancho. Conclusión: El diente autógeno extraído de forma inmediata utilizado como material de injerto para la conservación del alveolo fresco es prometedor para la práctica clínica diaria futura. Se necesitan más estudios clínicos comparativos

Second Mesiobuccal Canal Evaluation Features with Cone-Beam Computed Tomography

Aim. The aim of the study is to evaluate the difference in MB2 prevalence with different slice thicknesses in maxillary first molars. Materials and Methods. Two hundred nonfilled MB2 canals in maxillary first molars of 156 people (75 females and 81 males) aged from 20 to 73 years old were evaluated with CBCT with different slice thicknesses: 0.5 mm, 1 mm, 3 mm, and 10 mm. A general analysis was performed out, as well as in the age groups and on gender groups. Results. Visualization with 0.5 mm and 1 mm slice thicknesses was 100% and generally equal, in both the male and the female group. General MB2 visualization with 3 mm slice thickness was 42% and 29% for the male group and 27% for the female group. No canals were visualized with 10 mm slice thickness. The study did not demonstrate a statistical difference in the MB2 prevalence between gender and age groups with the 3 mm slice thickness. Conclusion. The most valuable way to evaluate the root canal system in first maxillary molars with CBCT is using 1 mm slice thickness for both genders and every age group

Exome, transcriptome and miRNA analysis don’t reveal any molecular markers of TKI efficacy in primary CML patients

Abstract Background Approximately 5–20% of chronic myeloid leukemia (CML) patients demonstrate primary resistance or intolerance to imatinib. None of the existing predictive scores gives a good prognosis of TKI efficacy. Gene polymorphisms, expression and microRNAs are known to be involved in the pathogenesis of TKI resistance in CML. The aim of our study is to find new molecular markers of TKI therapy efficacy in CML patients. Methods Newly diagnosed patients with Ph+ CML in chronic phase were included in this study. Optimal and non-optimal responses to TKI were estimated according to ELN 2013 recommendation. We performed genotyping of selected polymorphisms in 62 blood samples of CML patients, expression profiling of 33 RNA samples extracted from blood and miRNA profiling of 800 miRNA in 12 blood samples of CML patients. Results The frequencies of genotypes at the studied loci did not differ between groups of patients with an optimal and non-optimal response to TKI therapy. Analysis of the expression of 34,681 genes revealed 26 differently expressed genes (p < 0.05) in groups of patients with different TKI responses, but differences were very small and were not confirmed by qPCR. Finally, we did not find difference in miRNA expression between the groups. Conclusions Using modern high-throughput methods such as whole-exome sequencing, transcriptome and miRNA analysis, we could not find reliable molecular markers for early prediction of TKI efficiency in Ph+ CML patients