1,793 research outputs found
Insights from the x-ray crystal structure of coral 8R-lipoxygenase: Calcium activation via a C2-like domain and a structural basis of product chirality
Lipoxygenases (LOXs) catalyze the regio- and stereospecific dioxygenation of polyunsaturated membrane-embedded fatty acids. We report here the 3.2 Å resolution structure of 8R-LOX from the Caribbean sea whip coral Plexaura homomalla, a LOX isozyme with calcium dependence and the uncommon R chiral stereospecificity. Structural and spectroscopic analyses demonstrated calcium binding in a C2-like membrane-binding domain, illuminating the function of similar amino acids in calcium-activated mammalian 5-LOX, the key enzyme in the pathway to the pro-inflammatory leukotrienes. Mutation of Ca2+- ligating amino acids in 8R-LOX resulted not only in a diminished capacity to bind membranes, as monitored by fluorescence resonance energy transfer, but also in an associated loss of Ca2+-regulated enzyme activity. Moreover, a structural basis for R chiral specificity is also revealed; creation of a small oxygen pocket next to Gly428 (Ala in all S-LOX isozymes) promoted C-8 oxygenation with R chirality on the activated fatty acid substrate. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc
Dynamics of Fractal Solids
We describe the fractal solid by a special continuous medium model. We
propose to describe the fractal solid by a fractional continuous model, where
all characteristics and fields are defined everywhere in the volume but they
follow some generalized equations which are derived by using integrals of
fractional order. The order of fractional integral can be equal to the fractal
mass dimension of the solid. Fractional integrals are considered as an
approximation of integrals on fractals. We suggest the approach to compute the
moments of inertia for fractal solids. The dynamics of fractal solids are
described by the usual Euler's equations. The possible experimental test of the
continuous medium model for fractal solids is considered.Comment: 12 pages, LaTe
Fractional derivatives of random walks: Time series with long-time memory
We review statistical properties of models generated by the application of a
(positive and negative order) fractional derivative operator to a standard
random walk and show that the resulting stochastic walks display
slowly-decaying autocorrelation functions. The relation between these
correlated walks and the well-known fractionally integrated autoregressive
(FIGARCH) models, commonly used in econometric studies, is discussed. The
application of correlated random walks to simulate empirical financial times
series is considered and compared with the predictions from FIGARCH and the
simpler FIARCH processes. A comparison with empirical data is performed.Comment: 10 pages, 14 figure
State transition of a non-Ohmic damping system in a corrugated plane
Anomalous transport of a particle subjected to non-Ohmic damping of the power
in a tilted periodic potential is investigated via Monte Carlo
simulation of generalized Langevin equation. It is found that the system
exhibits two relative motion modes: the locking state and the running state.
Under the surrounding of sub-Ohmic damping (), the particle should
transfer into a running state from a locking state only when local minima of
the potential vanish; hence the particle occurs a synchronization oscillation
in its mean displacement and mean square displacement (MSD). In particular, the
two motion modes are allowed to coexist in the case of super-Ohmic damping
() for moderate driving forces, namely, where exists double centers
in the velocity distribution. This induces the particle having faster
diffusion, i.e., its MSD reads . Our result shows that the effective power index
can be enhanced and is a nonmonotonic function of the
temperature and the driving force. The mixture effect of the two motion modes
also leads to a breakdown of hysteresis loop of the mobility.Comment: 7 pages,7 figure
Levi-Civita cylinders with fractional angular deficit
The angular deficit factor in the Levi-Civita vacuum metric has been
parametrized using a Riemann-Liouville fractional integral. This introduces a
new parameter into the general relativistic cylinder description, the
fractional index {\alpha}. When the fractional index is continued into the
negative {\alpha} region, new behavior is found in the Gott-Hiscock cylinder
and in an Israel shell.Comment: 5 figure
Anomalous Rotational Relaxation: A Fractional Fokker-Planck Equation Approach
In this study we obtained analytically relaxation function in terms of
rotational correlation functions based on Brownian motion for complex
disordered systems in a stochastic framework. We found out that rotational
relaxation function has a fractional form for complex disordered systems, which
indicates relaxation has non-exponential character obeys to
Kohlrausch-William-Watts law, following the Mittag-Leffler decay.Comment: Revtex4, 9 pages. Paper was revised. References adde
Transport Equations from Liouville Equations for Fractional Systems
We consider dynamical systems that are described by fractional power of
coordinates and momenta. The fractional powers can be considered as a
convenient way to describe systems in the fractional dimension space. For the
usual space the fractional systems are non-Hamiltonian. Generalized transport
equation is derived from Liouville and Bogoliubov equations for fractional
systems. Fractional generalization of average values and reduced distribution
functions are defined. Hydrodynamic equations for fractional systems are
derived from the generalized transport equation.Comment: 11 pages, LaTe
Fractional Generalization of Gradient Systems
We consider a fractional generalization of gradient systems. We use
differential forms and exterior derivatives of fractional orders. Examples of
fractional gradient systems are considered. We describe the stationary states
of these systems.Comment: 11 pages, LaTe
Fractional Variations for Dynamical Systems: Hamilton and Lagrange Approaches
Fractional generalization of an exterior derivative for calculus of
variations is defined. The Hamilton and Lagrange approaches are considered.
Fractional Hamilton and Euler-Lagrange equations are derived. Fractional
equations of motion are obtained by fractional variation of Lagrangian and
Hamiltonian that have only integer derivatives.Comment: 21 pages, LaTe
Psi-Series Solution of Fractional Ginzburg-Landau Equation
One-dimensional Ginzburg-Landau equations with derivatives of noninteger
order are considered. Using psi-series with fractional powers, the solution of
the fractional Ginzburg-Landau (FGL) equation is derived. The leading-order
behaviours of solutions about an arbitrary singularity, as well as their
resonance structures, have been obtained. It was proved that fractional
equations of order with polynomial nonlinearity of order have the
noninteger power-like behavior of order near the singularity.Comment: LaTeX, 19 pages, 2 figure
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