Türkiye'de tıbbi bitkilerin korunmasına genel bakış

Medicinal plants are a special area that needs to be evaluated with different parameters than the general biodiversity threatening due to intense collection pressure. In the study, Turkey's plant diversity, requirements and strategies for sustainable use of Turkish medicinal plants, criticizing and planning of data for the protection of medicinal plants have been evaluated using standards of the Guidelines on the Conservation of Medicinal Plants by WHO, IUCN, WWF and Traffic. In addition, the richness of traditional medicinal plant uses in Turkey, the concept, and usage potentials, administrative requirements for the protection, creation of the in situ and ex situ conservation areas and recommendations for the future have been presented.Tıbbi bitkiler yoğun bir toplama baskısı nedeniyle genel biyoçeşitlilik üzerindeki baskıdan daha farklı parametrelerle değerlendirilmesi gereken bir alandır. Çalışmada, Türkiye’nin bitki zenginliği, tıbbi bitki olarak kullanılan bitkilerin sürdürülebilir kullanımı için gereksinimler ve stratejiler, verilerin ve tıbbi bitkilerin korunmasına yönelik planlamalar, WHO, IUCN, WWF ve Traffic tarafından hazırlanmış Tıbbi Bitkileri Koruma Kılavuzu’na göre değerlendirilmiştir. Ayrıca Türkiye’nin geleneksel tıbbi bitki kullanım zenginliği, tıbbi bitki kavramı ve kullanım potansiyeli, korumaya yönelik yönetimsel gereksinimler, in situ ve ex situ koruma alanlarının oluşturulması ve geleceğe yönelik öneriler sunulmuştur

Concomitantly intra-articular fracture of proximal condylar second and third proximal phalanges: A rare case report

AbstractIntroductionA rare case of proximal phalange fractures has been presented in this study.Presentation of caseA 29-year-old male patient from Turkey was admitted to the orthopedics and traumatology clinic with a complaint of left hand pain, which had persisted for 10days. He described a rotational trauma that had occurred right after hitting his hand on the wheel of a car as a result of an in-car traffic accident 10days ago. Radiological work-ups were requested. In the anteroposterior (AP) graph of the case in which the fracture line could not be observed in the oblique graph, unicondylar fractures in the proximal section of the second and third proximal phalanges have been observed. Surgical treatment was not planned because 10days had passed since the trauma. In the control graphs taken after 3 weeks, healing at the fracture site was observed, and he was referred to physiotherapy after the removal of the splint. A good result was observed after physiotherapy.DiscussionBecause of the extension of tendons is important over the bone, the goal of the treatment is not only to heal the fracture, but also to preserve the sliding mechanism of these tendons. Regarding to lack of soft tissue trauma, favored joint movements after the healing of the fracture can be achieved more easily with conservative treatment; however, the fracture must be closely followed up.ConclusionCondylar fractures of proximal phalanges those nondisplaced can be conservatively treated with closed methods

Two Siblings with Isolated GH Deficiency Due to Loss−of−Function Mutation in the GHRHR Gene: Successful Treatment with Growth Hormone Despite Late Admission and Severe Growth Retardation

Patients with growth hormone releasing hormone receptor (GHRHR) mutations exhibit pronounced dwarfism and are phenotypically and biochemically indistinguishable from other forms of isolated growth hormone deficiency (IGHD). We presented here two siblings with clinical findings of IGHD due to a nonsense mutation in the GHRHR gene who reached their target height in spite of late GH treatment. Two female siblings were admitted to our clinic with severe short stature at the age of 13.8 (patient 1) and 14.8 years (patient 2). On admission, height in patient 1 was 107 cm (−8.6 SD) and 117 cm (−6.7 SD) in patient 2. Bone age was delayed in both patients (6 years and 9 years). Clinical and biochemical analyses revealed a diagnosis of complete IGHD (peak GH levels on stimulation test was 0.06 ng/mL in patient 1 and 0.16 ng/mL in patient 2). Patients were given recombinant human GH treatment. Genetic analysis of the GH and GHRHR genes revealed that both patientscarried the GHRHR gene mutation p.Glu72X (c.214 G>T) in exon 3 in homozygous (or hemizygous) state. After seven years of GH treatment, the patients reached a final height appropriate for their target height. Final height was 151 cm (−1.5 SD) in patient 1 and 153 cm (−1.2 SD) in patient 2. In conclusion, genetic analysis is indicated in IGHD patients with severe growth failure and a positive family history. In spite of the very late diagnosis in these two patients who presented with severe growth deficit due to homozygous loss−of−function mutations in GHRHR, their final heights reached the target height

The treatment of acute myocardial infarction due to the occlusion of the left main coronary disease

Acute myocardial infarction (AMI) due to the occlusion of the left main coronary artery (LMCA) is a rare but serious condition in the era of percutaneus coronary intervention (PCI). Even more rare is AMI involved with both LMCA and its branches like trifurcartion or bifurcation: this is challenging for interventional cardiologists, because it involves the extension of the myocardium complicated by cardiogenic shock and its technical difficulties. Trifurcating coronary artery disease is a complex atherosclerotic process involving the origin of one or more of three side branches arising from a left main coronary vessel or trunk, with or without the involvement of LMCA itself. There is no classification or standardized methodology to treat LMCA disease in elective percutaneous intervention procedures. Furthermore, acute myocardial infarction presenting with left main coronary artery trifurcation lesion seems to be more troublesome, especially in young patients. Few series of PCI on significant lesions of the left main trifurcations have been described. Herein, we describe a patient who successfully underwent PCI and was supported by post intravascular ultrasound sonography and multislice computed angiography (MSCA), and after an uneventful follow-up with MSCA is now on the ninth month. (Cardiol J 2011; 18, 1: 77-82

Evaluation of Antibiotic Alternatives Used in Orthopedic Departments of 2 Hospitals According to Rational Use of Antibiotics

Amaç: Birbirine yakın ve aynı bölgede yer alan iki farklı hastanenin ortopedi ve travmatoloji servislerinde yatan hastalarda, etkeni saptanan enfeksiyon olgularında antibiyotik kullanımının, akılcı ilaç tedavi rehberleri ve kültür antibiyogram sonuçlarına göre uygunluğunun araştırılması amaçlandı.Gereç ve Yöntem: Bu araştırma projesi T.C. Sağlık Bakanlığı Genel Sekreterlik İzni doğrultusunda 01 Ocak 2014 ile 31 Aralık 2014 tarihleri arasında, iki hastanenin ortopedi ve travmatoloji servislerinde enfeksiyon tanısına sahip olguların verileri üzerinden gerçekleştirildi. Malignitesi olan veya başka bir servise taburcu edilen olgular çalışmadan dışlandı. Standart bir form oluşturuldu. Bu form içerisine, olguların demografik verilerine ek olarak, kültür antibiyogram sonuçları, enfeksiyon patojen etkeni, kültür materyalinin nereden alındığı, kullanılan antibiyotiklerin pozolojisi, süresi ve uygunluğu ile olguların yatış süreleri raporlandı. Maliyetlerin hesaplanmasında, Sağlık Bakanlığı ve Maliye Bakanlığı 2014 yılı fiyat listeleri temel alındı. Birim fiyat üzerinden hasta başına kullanılan antibiyotik maliyetleri hesaplandı.Bulgular: Saptanan enfeksiyon etkeni için her zaman uygun antibiyotiğin seçilmediği belirlendi. Antibiyogram sonuçlarına göre etkili, daha düşük maliyetli antibiyotikler kullanılabilinmesine rağmen sıklıkla daha pahalı ve toplam maliyeti yükselten antibiyotikler seçilmiştir.Sonuç: Kanıta dayalı tıp ve akılcı antibiyotik kullanımı kapsamında enfeksiyon tedavisinde kültür antibiyogram sonuçlarına göre uygun antibiyotik seçilmesi gerekliliği tartışılmaz bir bilimsel gerçektir. Ortopedi ve travmatoloji servislerinde enfeksiyon tedavisinde enfeksiyon hastalıkları ve farmakoloji uzmanlarını da sürece katarak multi-disipliner yaklaşılarak kanıta dayalı rehberlerin kullanımının artışı sağlanmalıdırBackground: The present study is an analysis of appropriateness of antibiotics use for patients in whom infectious agent was detected. Data from patients in orthopedics and traumatology department of 2 hospitals in the same district were evaluated according to rational antibiotic drug use guidelines and culture antibiogram results.Methods: Data of patients diagnosed with infection between January 1, 2014 and December 31, 2015 in orthopedics and traumatology department of 2 different hospitals were analyzed. Patients diagnosed with malignancy or who were discharged from other departments were excluded. A standard form was used to collect demographic data, culture antibiogram results, details of infectious agent, source of culture material, posology of antibiotic used, duration and appropriateness of use, and length of hospital stay. Costs were estimated based on number of units used and price per unit according to 2014 Ministry of Health price list. Mean price of antibiotics used per patient was calculated and descriptive analyses were also completed.Results: It was determined that appropriate antibiotics for detected infectious agent were not always selected. Though there were effective, less expensive antibiotics that could have been used according to antibiogram results, more expensive antibiotics were often chosen, resulting in greater total cost.Conclusion: Multidisciplinary approach in patient care and use of evidence-based guidelines should be increased. Teams should be formed and led by infectious disease and pharmacology specialists. New strategies should be developed immediately in health economics and new pharmacoeconomic models should be initiated in orthopedics and traumatology department

Effects of observer dynamics on motion stability of autonomous vehicles

The problem of loss of stability of marine vehicles under cross track error control in the presence of mathematical versus actual system mismatch is analyzed. For demonstration purposes, variations in the heading angle control gain are studied. Particular emphasis is placed on analyzing the effects of observer design on system response after initial loss of stability of straight line motion. It is shown that the dynamics of the observer may have a significant effect on the computed gain margin of the control system depending on the particular basis usedhttp://archive.org/details/effectsofobserve00olcaLieutennat JG, Turkish NavyApproved for public release; distribution is unlimited

Medicinal Plants Used In Traditional Treatment of Hypertension in Turkey

Since ancient times people have used plants because of their therapeutic effects. People have recorded the therapeutic effects of plants throughout history. Turkey has a rich traditional medicine and ethnobotanical culture. People have preserved this ethnobotanical culture by transferring them from generation to generation. Medicinal plants are playing an important role in health care programmes worldwide, especially in developing countries. In Turkey there are many plant species known with their blood pressure lowering effect. In this study 150 plant taxa, used against hypertension in Turkey were compiled. The study contains botanical names, families, local names, used parts and method of use of these plant species. According to this research commonly used medicinal plants are from Rosaceae (27 taxa), Lamiaceae (26 taxa), Asteraceae (15 taxa), Apiaceae (11 taxa), Polygonaceae (6 taxa), Loranthaceae (3 taxa) and Rhamnaceae (3 taxa) respectively

About the presence of Pulmonaria angustifolia L. (Boraginaceae) in Turkey

Background and Aims: Approximately 12,000 plant species grow naturally in Turkey. About 3500 of them are endemic. This number is increasing day by day with new floristic studies. The aim of this study; to confirm the existence of the Pulmonaria angustifolia L. species, whose record is suspicious. Methods: This study is based on a herbarium sample collected by Bülent Olcay during the field study conducted in Western Anatolia (Bursa) in April 2019. As a result of the various relevant floras and literature studies, the specimen was identified as P. angustifolia. The P. angustifolia sample was confirmed by comparison with various herbarium samples. In this study, a description of the Pulmonaria angustifolia species was given. The species was examined in detail morphologically and compared with other herbarium samples. Results: The presence of the P. angustifolia species, which has been mentioned as a doubtful record in the flora of Turkey, has been proven for the first time in Turkey. A new record has been added that the Pulmonaria species grow in Turkey. An identification key has been established for the Pulmonaria species found in Turkey, including the new record. Conclusion: With this study, presence of P. angustifolia, which is mentioned as doubtful record is confirmed. Keywords: Pulmonaria, Boraginaceae, new record, Turke

An ethnobotanical study of Elmasuyu village, Elazığ (Eastern Anatolia) in Turkey

This study contains the results of ethnobotanical investigations carried out to determine what plants are used by the people of Elmasuyu village in the Sivrice district of Elazığ. For this purpose, several field studies were conducted in 2018 and 2019 in Elmasuyu village. During the field studies, 76 plant specimens were collected and identified and ethnobotanical information concerning these plants was recorded. The voucher specimens were stored in the Herbarium of the Faculty of Pharmacy, Istanbul University (ISTE) and in the personal herbarium of Rümeysa GÜL (RG). Ethnobotanical uses of the plants were recorded by interviewing volunteers from the people of Elmasuyu village. The study was focused on identifying the collected species, on the diseases treated by them, parts of the used plants, methods of preparation and administration. FIC values and Use Values were calculated to identify the potentially effective medicinal plants. Data obtained in Elmasuyu village were compared with those from the earlier ethnobotanical studies in Eastern Anatolia