Seroprevalence and determinants of Helicobacter pylori infection among asymptomatic under-five children at a Tertiary Hospital in the South-Western region of Nigeria

Background: The epidemiology of Helicobacter pylori (H. pylori) infection among under-five children in the South West Nigeria remains largely understudied. There is no data on the subject from the study area.Objectives: This study was conducted to assess the seroprevalence of H. pylori infection among under-five children at a tertiary hospital in the South Western, Nigeria and to determine its associated socio-demographic factors.Methods: Sera of 360 children were analyzed for anti H. pylori Ig G using enzyme linked immunosorbent assay test kit (BQ ELISA Ig G KIT) and H. pylori infection risk factors were determined. Determinants of H. pylori infection was determined using binary logistic regression analysis and p-values < 0.05 were taken as statistically significant.Results: H. pylori infection seroprevalence rate was 32.8% and increased with age. Living in one room accommodation, large families, playing with soil, family history of dyspepsia, practice of premastication, sharing of plates and cutlery, and water closet toilet were associated with H. pylori Ig G seropositivity (p<0.05) on binary regression analysis.Conclusion: The seroprevalence of H. pylori infection in under -five children is high, increasing as the age of the children increased. This may suggest that instituting preventive measures at young age, targeting identified factors may be effective in reducing the burden of H. pylori infection.Keywords: Helicobacter pylori, South-Western Nigeria

Perception of Nurses about Palliative Care: Experience from South-West Nigeria

Background: Nurses play a major role all over the world in the palliative care team.Aim: The aim of this study was to investigate the knowledge and attitude of nurses toward palliative care in a tertiary level hospital in Nigeria. Subjects and Methods: Setting: This cross-sectional questionnaire-based study was carried out among nurses at a tertiary health care facility inAdo-Ekiti, South-West Nigeria. Design: A cross-sectional questionnaire-based study was carried out. The questionnaire sought information about the sociodemographic profile of respondents, their knowledge of definition and philosophy of palliative care among other things. Descriptive statistics was used to obtain the general characteristics of the study participants, while Chi-square was used to determine the association between categorical variables. A two-sided P < 0.05 was considered as significant.Results: A total of 100 questionnaires were returned with a female preponderance among the respondents with F: M ratio of 9:1. Regarding the definition of palliative care, 71.8% (48/66) of the respondents  understood palliative care to be about pain medicine, 55% (33/60) thought it to be geriatric medicine, while 90.2% (83/92) felt palliative care is about the active care of the dying. Exactly 80.5% (66/82) respondents agreedthat palliative care recognizes dying as a normal process while 84.1% (74/88) respondents were of the opinion that all dying patients would require palliative care. The use of morphine would improve the quality of life of patients according to 68.9% (42/61) of respondents.Conclusion: There are gaps in the knowledge of healthcare workers in the area of palliative care and this call for a review of the current nursing curriculum and practice guidelines in Nigeria.Keywords: End of life, Nursesf attitude, Pain management, Palliative car

Socio-demographic correlates of childhood malnutrition in a rural community in Southwest Nigeria - A call for targeted interventions for vulnerable children

BACKGROUND: Nigeria has the second-highest burden of stunted children globally. Yet, only two out of ten malnourished Nigerian children benefit from intervention programs to address malnutrition. This study describes some socio-demographic factors associated with malnutrition among children living in a rural community in Southwest Nigeria. METHODS: This study was a community-based cross-sectional study involving 364 children randomly selected from their homes aged 1–15 years. Factors such as socioeconomic status, birth order, and whether the mother was alive were obtained. Weights, heights, and body mass index (BMI) were measured and interpreted using the WHO z-scores. Chi-squared test of associations was used for categorical variables and an independent t-test was used to compare the mean BMI between both genders. The level of significance was set at a p-value <0.050. RESULTS: There were 185 (51%) females: 173(48%) belonged to the age group 1–5 years and 168 (46%) belonged to the lower socio-economic class. Over 80% of the participants had normal nutritional status: 19 (6%) were underweight, 36 (10%) were stunted, and 29 (8%) were thin (low BMI, <-2SD). Maternal demise was associated with thinness. Males from lower socio-economic classes and first-born males had a higher mean BMI than the females (p<0.050). CONCLUSION: Although malnutrition prevalence was low, there is a need to use targeted interventions to further reduce malnutrition among vulnerable children. There is also a necessity for more studies to identify and address the risk factors for stunting in the study area

Langmuir, Freundlich, Temkin and Dubinin–Radushkevich Isotherms Studies of Equilibrium Sorption of Zn 2+ Unto Phosphoric Acid Modified Rice Husk

Equlibrium sorption of the phosphoric acid modified rice husk was studied. The Physico-chemical properties of the modified rice husk were determined. The equilibrium sorption data were fitted into Langmuir, Freundlich, Temkin and Dubinin–Radushkevich (DRK) isotherms. Of the four adsorption isotherm, the R2 value of Langmuir isotherm model was the highest. The maximum monolayer coverage (Qo) from Langmuir isotherm model was determined to be 101.01mg/g, the separation factor indicating a favourable sorption experiment is 0.133. Also from Freundlich Isotherm model, the sorption intensity (n) which indicates favourable sorption and the correlation value are 1.6 and 0,89 respectively. The heat of sorption process was estimated from Temkin Isotherm model to be 25.34J/mol and the mean free energy was estimated from DRK isotherm model to be 0.7KJ/mol which vividly proved that the adsorption experiment followed a physical process. Keywords: Heavy metals, Isotherms, Rice husk and Sorption

Seroprevalence and determinants of Helicobacter pylori infection among asymptomatic under-five children at a Tertiary Hospital in the South-Western region of Nigeria

Background: The epidemiology of Helicobacter pylori (H. pylori) infection among under-five children in the South West Nigeria remains largely understudied. There is no data on the subject from the study area. Objectives: This study was conducted to assess the seroprevalence of H. pylori infection among under-five children at a tertiary hospital in the South Western, Nigeria and to determine its associated socio-demographic factors. Methods: Sera of 360 children were analyzed for anti H. pylori Ig G using enzyme linked immunosorbent assay test kit (BQ ELISA Ig G KIT) and H. pylori infection risk factors were determined. Determinants of H. pylori infection was determined using binary logistic regression analysis and p-values < 0.05 were taken as statistically significant. Results: H. pylori infection seroprevalence rate was 32.8% and increased with age. Living in one room accommodation, large families, playing with soil, family history of dyspepsia, practice of premastication, sharing of plates and cutlery, and water closet toilet were associated with H. pylori Ig G seropositivity (p<0.05) on binary regression analysis. Conclusion: The seroprevalence of H. pylori infection in under -five children is high, increasing as the age of the children increased. This may suggest that instituting preventive measures at young age, targeting identified factors may be effective in reducing the burden of H. pylori infection. DOI: https://dx.doi.org/10.4314/ahs.v19i2.32 Cite as: Babatola AO, Akinbami FO, Adeodu OO, Ojo TO, Efere MO, Olatunya OS. Sero-prevalence and determinants of Helicobacter pylori infection among asymptomatic under-five children at a tertiary hospital in the South-Western region of Nigeria. Afri Health Sci.2019;19(2): 2082-2090. https://dx.doi.org/10.4314/ahs.v19i2.3

Adherence to WHO criteria on drug promotion literature : an exploratory study from a tertiary healthcare facility in South-West Nigeria

INTRODUCTION: In many low and middle-income countries (LMIC), drug promotional literature (DPL) remains one of the main sources of drug information for physicians. Studies conducted in many LMICs showed poor compliance to the WHO guidelines for ethical drug promotion especially in the area of information about excipients, adverse drug reactions, drug-drug interactions and contra-indications. These inadequacies in the information provided may mislead the prescriber with potential adverse consequences among patients using the medicines. Nigeria has a big pharmaceutical sector which is poorly regulated and we hypothesize that such unethical drug promotional practices may exist. This study therefore set out to assess compliance to the WHO ethical drug promotion (using DPL) at the Ekiti State University Teaching Hospital (EKSUTH), Ado-Ekiti, South-West Nigeria. METHODOLOGY: This was a descriptive cross-sectional study conducted in several specialist clinics of EKSUTH, Ado-Ekiti. Printed DPLs (brochures and leaflets) were collected from these clinics, collated using a pre-designed data collection form and analyzed using the WHO ethical criteria for medicinal drug promotion. RESULTS: A total of 234 DPLs were selected after screening to remove duplications. DPLs promoting antibiotics, cardiovascular drugs and vitamins/ nutritional supplements were in the majority (22.2%, 17.1% and 11.5% respectively. Most of the DPLs had the generic (223; 95.3%) and brand (234; 100%) names, active ingredients (209; 89.3%), excipients (149; 63.7%) and indications (232; 99.1%). Information about adverse drug reactions (76; 32.5%), contra-indications (73; 31.2%) and drug interactions (46; 19.7%) was less represented. Only fifty-nine (25.2%) DPLs had references. Fixed-dose combination drugs made up 34.6% of drugs being promoted. CONCLUSION: The DPLs assessed in this study had low adherence to WHO ethical drug promotion criteria especially those related to adverse drug reaction, drug interactions and contra-indications

Paediatric brought-in-dead at a tertiary health facility in South western Nigeria: Patterns and drivers

Background: ‘Brought- in-dead’ (BID) refers to the demise of an individual before presentation to a health facility. This study assessed the pattern of paediatric BID cases seen at a tertiary health facility in southwest Nigeria. Method: A cross-sectional, descriptive study was done at the Children Emergency Ward (CEW) of the hospital between January 2014 and December 2018. The patterns of BID cases and presumed causes of death were determined using a standardized checklist adapted from the WHO verbal autopsy instrument. Results: Ninety-eight BID cases were seen during the study, constituting 2.5% of total patients seen during the period. The median (IQR) age of cases was 24.0 (8.75 – 63.0) months and 72.4% were under-fives. Most had symptoms related to the haematologic (36.7%), respiratory (24.5%) or digestive (20.4%) systems. Severe anaemia 31(31.6%), gastroenteritis 19 (19.4) and aspiration 17 (17.3%) were the most common causes of death. The median (IQR) duration of illness before presentation was 3.0 (1.0 – 7.0) days but most presented from 4 – 7 days of illness. A significant relationship was found between the duration of illness and whether or not pre-hospital treatment was received (p < 0.0001). Unprescribed drugs purchased over the counter were the most commonly used treatment in 79.1% of cases (p < 0.0001). Conclusion: This study has highlighted the prevalence and pattern of paediatric BID in a tertiary health facility in southwest Nigeria and the factors that were associated with it. More efforts need to be geared towards community sensitization and pediatric health care to prevent factors drivingits menace

Addressing antimicrobial resistance in Nigerian hospitals : exploring physicians prescribing behavior, knowledge, and perception of antimicrobial resistance and stewardship programs

Introduction: We assessed the knowledge of, attitude toward antimicrobial resistance (AMR) and practice of antimicrobial stewardship (AMS) among physicians in Nigeria to provide future guidance to the Nigerian National Action Plan for AMR. Methods: A descriptive cross-sectional questionnaire-based study explored the physicians’ self-reported practice of antibiotic prescribing, knowledge, attitude, and practice of AMR and components of ASPs. Results: The majority (217; 67.2%) of respondents prescribed antibiotics daily in their clinical practice AMR was recognized as a global and local problem by 308 (95.4%) and 262 (81.1%) respondents, respectively. Only 91 (28.2%) of respondents have ever heard of antibiotic stewardship. The median AMR knowledge score was 40 (19–45)out of 45while that for ASP was 46.0(32–57) out of 60. There was significant statistical difference between the ASP median scores among the medical specialties category (P value <0.0001) More respondents had good knowledge of AMR than ASPs (82.7% versus 36.5%; p < 0.0001). Conclusion: Respondents in this study were more knowledgeable about AMR than AMS and its core components

Ideal Male-Oriented Sexual and Reproductive Health Services Delivery: A Qualitative Study of Men and Healthcare Providers’ Perspective from Nigeria

INTRODUCTION: The global burden of Sexual and Reproductive Health (SRH) problems has remained a significant challenge to the wellbeing of men and limits the effectiveness of SRH interventions for females. This study explored men and healthcare providers’ perception of ideal male-oriented Sexual and Reproductive Health (SRH) services. METHODS: This was an exploratory qualitative study involving three focus group discussions among men in selected communities and eight interviews among healthcare service providers in Ekiti State, Nigeria. Focus Group Discussion (FGD) and Key Informant Interview (KII) guides were used to collect qualitative data from twenty-six men and eight healthcare service providers, respectively. Participants for the study were selected from three different units of the selected hospital and twelve communities. Data were sorted, transcribed, and analyzed using Atlas ti software. Inductive-deductive thematic analysis was performed. RESULTS: Three main themes emerged from the study: (a) ideal men-oriented SRH service provision within a unit specially made and named after men, (b) 24-hour daily SRH clinic and (c) locating SRH Clinic in the healthcare institutions with outlets in the communities and schools. The participants identified primary needs as SRH organs assessments; screening services; family planning services; and education and counselling on prevention and treatment of male SRH problems. CONCLUSION: Men have SRH service preferences that focused on preventive and therapeutic sexual and reproductive health needs that are desired to be male-oriented, dedicated and provided in health facilities with public outlets

In Vivo Toxicity Studies and Phytochemical Screening of Stem Bark of Ficus Sycomorus Linn (Moraceae)

This research paper has investigated the In vivo toxicity studies and phytochemical screening of Stem bark of Ficus sycomorus Linn (Moraceae). Ethno-pharmacological relevance of Ficus sycomorus is quite obvious. It finds relevance in the treatment of Diabetes mellitus and other infectious diseases in the Northern part of Nigeria. The preliminary phytochemical screening of the extract revealed the presence of flavonoids, glycosides, reducing sugars, resins, saponins and tannins. The result of the experimental study carried out on albino rat which is close to human being indicates that stem bark extract of F. sycomorus produces toxicity at a dose of 1500 mg/kg. The outcome of this study offers support to the Ethno-medicinal uses of F. sycomorus in the treatment of various ailments. Keyword: F. sycomorus, Phytochemical, Saponins, flavonoids, glycosides, reducing sugars and Toxicit