Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling

Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models. In this study the influence of B. ferruginea (BFE) on the production of PGE2, nitrite, and proinflammatory cytokines from LPS-stimulated BV-2 microglia was investigated. The effects of BFE on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expressions were evaluated in LPS-activated rat primary microglia. The roles of NF-κB and MAPK signalling in the actions of BFE were also investigated. BFE (25–200 μg) inhibited the production of PGE2, nitrite, tumour necrosis factor-α (TNFα), and interleukin-6 (IL-6) as well as COX-2 and iNOS protein expressions in LPS-activated microglial cells. Further studies to elucidate the mechanism of anti-inflammatory action of BFE revealed interference with nuclear translocation of NF-κBp65 through mechanisms involving inhibition of IκB degradation. BFE prevented phosphorylation of p38, but not p42/44 or JNK MAPK. It is suggested that Bridelia ferruginea produces anti-inflammatory action through mechanisms involving p38 MAPK and NF-κB signalling

Security and Privacy Issues in IoT Healthcare Application for Disabled Users in Developing Economies

In this paper, we explore the security and privacy issues of Internet of Things (IoT) healthcare applications for special needs users. IoT enables health-related organizations to lift important data from diverse sources in real-time and this helps in precise decision-making. The transformation of the health sector, required enhancement and efficiency of protective systems, thereby reducing data vulnerability and hence, providing opportunities for secure patient data, particularly, for special needs patients. A quantitative method for purposive sampling technique was adopted and eighty-eight respondents provided the process of how the IoT technology was utilised. Data findings indicated that IoT monitoring devices have the detective ability for a person with special needs living alone with problems related to vital signs of diseases or disabilities. Personal patient health records are integrated into the e-health Centre via IoT technologies. For data privacy, security, and confidentiality, patients' records are kept on Personal Health Record Systems (PHRS). The research revealed suspected breaches of information due to cyber-attacks on the probability of false data errors in the PHRS, leading to special needs personal data leakage

Evaluation of CD4+ T Cells in HIV Patients Presenting with Malaria at the University of Ilorin Teaching Hospital Nigeria

CD4 count is an important immunological marker of disease progression in HIV seropositive patients. This study was carried out to determine the effect of malaria or fever of unknown origin on the population of CD4+ T lymphocytes of HIV seropositive patients attending the highly active antiretroviral therapy (HAART) clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 36 subjects were selected for this study. Ongoing history of fever was used as a case definition for malaria and malaria was confirmed from microscopic examination of thick and thin film of blood sample obtained from the patients during presentation with fever. The CD4 count was evaluated during presentation of fever and post-fever using flow cytometry. There was significant decrease in CD4 count of the patients. However, upon classifying the patients into 2 groups - those that returned to the clinic after a week and those that returned after a month - a significant increase in CD4 count was noticed in the group that returned after a week, while a significant decrease was noticed in the group that returned after a month (at p value of 95%). Further classification of the patients based on presence of malaria parasite, and body temperature resulted in varying effects on CD4 count post-fever (in the general group, 27 were positive for malaria parasites. Of these 27, there was an increase in CD4 count in 9 (33.3%). However in the group that returned after a week, all 6 (100%) that were positive for malaria parasites showed increase in CD4 count. Five (26.3%) of the 19 patients that had body temperature within the range of 35.5-37.4^o^C showed an increase in CD4 count, while 7 (41.2%) the 17 patients that had body temperature of 37.5^o^C and above showed an increase in CD4 count. The results led to the conclusion that while some components of the immune response to malaria could strengthen the immune system of HIV seropositive patients by increasing their CD4 count, other components will suppress their immunity by decreasing their CD4 count, accelerating the progression to AIDS

Economic Efficiency of Yam Production in Oyo State of Nigeria

This study estimates economic efficiency of yam growing farmers in Oyo State of Nigeria using stochastic frontier production function. The empirical application used farm level data collected from 120 farms following 2007/2008 growing season. The results indicate that farm size, hired labour, yam set and equipment are the major factors that influence changes in yam output. Farm specific variables, such as farming experience, diversification and extension, were the significant factors influencing inefficiency among yam producers. Predicted economic efficiencies range between 0.0094 and 0.876 with a mean economic efficiency of 0.594. Based on these results, sample yam producers could increase their output by 40.6% through better use of available resources

Paediatric surgical abdominal emergencies in a north central Nigerian centre

Background/objective Paediatric surgical abdominal emergencies (PSAEs) account for 2.4–3.1% of all paediatric admissions. The causes of PSAEs vary worldwide, and the management is challenging, often with unimaginably poor outcome if not carefully handled. The aim of this study was to determine the patterns and factors influencing the outcome of PSAE at a tertiary healthcare centre in Nigeria.Patients and methods The biodata, clinical features, perioperative findings and outcome of management of 100 consecutive children aged up to 12 years with confirmed PSAE were prospectively collected and analysed using SPSS 15.0 software, taking P-value to be < 0.05. Five children who had undergone an initial surgical intervention and those who were discharged against medical advice during care were excluded.Results The 100 children included in this study constituted 38.3% and 3.4% of the total paediatric surgical operations and paediatric admissions that took place during the study period, respectively. Their mean age was 4.6 ±0.469 years, and the male-to-female ratio was 2.5 : 1. About 64% of patients presented within the first 5 days of onset of symptoms with abdominal pain/distension and/or vomiting as chief complaint. Fourteen (63.7%) of patients with perforated typhoid ileitis presented after a week, whereas 10% presented with the same symptoms after 2 weeks. Mechanical intestinal obstruction was the most common cause of PSAE among neonates and infants, whereas peritonitis was the main presenting cause in late childhood (7–12 years). Only 54 patients underwent surgical intervention within 24 h of presentation. Twenty-four (24%) patients underwent surgical intervention after 48 h. The main causes of delay for surgical intervention were hospital logistics in 58 patients and lack of funds to procure drugs and consumables in nine patients. The overall median hospital stay was 10 days. Eighty-nine (89%) patients were discharged, whereas 11 (11%) died. Mortality was significantly higher in neonates and infants (P = 0.016) and in those with peritonitis (P = 0.008).Conclusion PSAE constitutes a large percentage of the paediatric surgical workload at our centre. Mechanical intestinal obstruction in neonates and infants is the leading cause. Aggressive resuscitation, accurate diagnosis, and prompt surgical intervention, in addition to provision of paediatric intensive care facilities, will assist in reducing morbidity and mortality among these children.Keywords: abdominal emergencies, acute abdomen, children, morbidity, mortalit

Missed medical appointment among hypertensive and diabetic outpatients in a tertiary healthcare facility in Ibadan, Nigeria

Purpose: To explore the reasons for missed medical appointment, patients’ awareness on its consequences; and to find strategies to reduce it among the study population.Methods: This was a descriptive cross-sectional survey among 300 hypertensive and 200 diabetic outpatients assessing care at the University College Hospital, Ibadan. Descriptive statistics was used to summarize data and categorical variables were compared with Chi-square at a level of significance set at p ≤ 0.05.Results: For hypertensive respondents, 16.7 % missed > 30 % of scheduled medical appointments while for diabetic respondents, it was 13.0 %; 59.7 % of the hypertensive respondents and 63.5 % of the diabetic respondents adhered to their medications. The reasons for missed medical appointments include forgetfulness, lack of funds for transport, conflicting commitments, etc. The level of awareness on the possible impact of missed medical appointments is low. Most of the respondents were of the opinion that those who missed appointments should be penalized, although a majority of them disagreed with the option of introducing financial penalties.Conclusion: The findings indicate that the reasons for missed medical appointment is mainly due to delay in attending to un-booked patients until all the scheduled patients are seen in order to reduce appointment non-adherence.Keywords: Missed medical appointments, Hypertensive, Diabetic outpatients, Medication adherence, Patient awarenes

Economic Efficiency of Yam Production in Oyo State of Nigeria

This study estimates economic efficiency of yam growing farmers in Oyo State of Nigeria using stochastic frontier production function. The empirical application used farm level data collected from 120 farms following 2007/2008 growing season. The results indicate that farm size, hired labour, yam set and equipment are the major factors that influence changes in yam output. Farm specific variables, such as farming experience, diversification and extension, were the significant factors influencing inefficiency among yam producers. Predicted economic efficiencies range between 0.0094 and 0.876 with a mean economic efficiency of 0.594. Based on these results, sample yam producers could increase their output by 40.6% through better use of available resources

Socio-Economic and Environmental Impact of Indiscriminate Burials on Property Transactions in Ado-Ekiti, Nigeria

Throughout history, almost all societies have employed different practices of disposing off the dead and one such form is cemetery or burial ground. In the western part of Nigeria, tradition demands that chiefs are not buried in public cemeteries but in secret locations preferably at home.  However, this practice have been flawed and currently, not only chief are buried at home but anybody.  Corpses are now buried indiscriminately in homes, front and back gardens without any recourse to the effect this practice have on the environment. . In view of the foregoing, the study delved into the socio-economic and environmental impact of indiscriminate burial within residential neighbourhood on property transaction in Ado- Ekiti, Western Nigeria. Questionnaire were structured and administered on tenants, landlords, government officials and professionals alike. Stratified sampling technique was adopted in that the city of Ado-Ekiti being the state capital was found suitable and was subsequently divided into the twelve political wards.  Two Hundred and Fifty (250) questionnaire were administered. Emphasis was played on buildings with evidence of tomb. Research findings proved that this practice was rampant especially in the core of the city and that no official (Planned) cemetery could be identified. The study identified the following demerits: environmental degradation; difficulty in land acquisition for public use; property devaluation; spiritual and psychological disturbance. Some of the coping measures suggested include: need for official provision of cemetery by government agencies, religious bodies and social organizations; need to enact enabling laws; public enlightenment and appeals and government at various levels to be more involved in the provision of mass housing to aid easy implementation of basic environmental laws among others Keywords: burial-ground, environment, indiscriminate, property value, socio-economic

Optimization of Deep-Fat Frying of Plantain Chips (Ipekere) using Response Surface Methodology

Deep-fat frying of plantain chips (ipekere) was investigated with the aim of predicting optimum operating conditions for plantain chips to minimize oil content in order to produce healthy products. The effect of frying temperature and time on moisture content, oil content, breaking force and colour difference of plantain chips was evaluated. Response surface methodology was used to analyze the results of the central composite design of the frying processes for the responses as a result of variation in the levels of frying temperature (150 – 190oC) and frying time (2 – 4 min). Response surface regression analysis shows that responses were significantly (p<0.05) correlated with frying temperature and time. Regression model was developed for the investigation of the effect of frying temperature and time on the responses. The polynomial regression models were validated with statistical tool whose values of coefficients of determination (R2) were 0.995, 0.982, 0.971 and 0.996 for moisture content, oil content, breaking force and colour difference, respectively. The optimum values of moisture content, oil content, breaking force and colour difference were 3.73%, 1.18%, 17.66 N and 65.53, respectively, at frying temperature of 183oC and frying time of 3 min. Therefore, frying conditions had a significant effect on the quality attributes of chips produced from plantain. Keywords: plantain chips, deep-fat frying, regression models, texture and colou

Endocrine disrupting compounds exposure and testis development in mammals

In the last few decades, there is substantial evidence that male reproductive function is deteriorating in humans and wildlife and this is associated with unintentional exposure to widely used synthetic chemicals. Subsequently, much has been done to show that certain chemicals in the environment adversely interfere with the developing fetal gonads of the laboratory animals. Some in vitro studies have demonstrated treatment-induced reproductive problems in offspring exposed to endocrine disrupting compounds (EDC) which are similar to those observed in wildlife and human population. Few EDC studies have demonstrated that there are certain periods of gestation when the developing fetus is highly sensitive and at risk of small endocrine changes. Similar observations have been made in the sewage sludge model, however, while animal studies have been insightful in providing valuable information about the range of effects that can be attributed to in utero exposure to EDCs, varying levels of maternal doses administered in different studies exaggerated extrapolation of these results to human. Thus the EDC concentration representative of fetal exposure levels is uncertain because of the complexities of its nature. So far, the level of fetal exposure can only be roughly estimated. There is substantial evidence from animal data to prove that EDCs can adversely affect reproductive development and function in male and more has accumulated on the mechanisms by which they exert their effects. This paper therefore, reviews previous studies to highlight the extent to which testis development can be disrupted during fetal life