Putting the “Gay” in Gamers: Increasing Identification with Homosexuals Through Video Games

Priming out-groups and taking the perspective of out-group members increases implicit and explicit identification with out-groups. Because the popularity of video games has increased dramatically over the past few decades and they have become an influential form of media, the current study investigated video games as another potential strategy to increase identification with and reduce prejudice against out-groups. Specifically, I investigated how manipulating the sexual orientation of the video game character participants used influenced implicit and explicit identification with homosexuals and implicit and explicit prejudice against homosexuals. Additionally, I investigated whether implicit and explicit identification with homosexuals would mediate the impact of video games on prejudice. Though I recruited enough participants to detect a medium effect size (169 participants in the final analyses), pre-registered analyses (osf.io/ynaw7) indicated that the sexual orientation of a video game character did not influence identification with or prejudice against homosexuals. Exploratory analyses demonstrated that among participants that identified with the video game character and played as a Gay character had increased explicit identification with and reduced prejudice against homosexuals. The possibility that increasing the strength of the manipulation by having participants play the game for multiple sessions, customize characters, and incorporating storytelling into the game are discussed

From Testing to Teaching: The Use of Interim Assessments in Classroom Instruction

The past ten years have witnessed an explosion in the use of interim assessments by school districts across the country. A primary reason for this rapid growth is the assumption that interim assessments can inform and improve instructional practice and thereby contribute to increased student achievement. Testing companies, states, and districts have become invested in selling or creating interim assessments and data management systems designed to help teachers, principals, and district leaders make sense of student data, identify areas of strengths and weaknesses, identify instructional strategies for targeted students, and much more. Districts are keeping their interim tests even under pressure to cut budgets (Sawchuk, 2009). The U.S. Department of Education is using its Race to the Top program to encourage school districts to develop formative or interim assessments as part of comprehensive state assessment systems. Much of the rhetoric around interim assessments paints a rosy picture, often with the ultimate claim that such measures will lead to increased student achievement. Much of the belief in the potential of interim assessments to improve student learning comes from the growing body of research on formative assessment. However, the majority of this research has not focused on interim assessments themselves, but rather practices that are embedded within classroom instruction. Very few studies exist on how interim assessments are actually used, by individual teachers in classrooms, by principals, and by districts. Furthermore, we know little about how teachers and other educators use the results from such assessments, the conditions that support their ability to use these data to improve instruction, or the interaction of interim assessments with other classroom assessment practices. Our study begins to fill that vacuum

Can Interim Assessments Be Used for Instructional Change

The purpose of this exploratory study was to examine the use of interim assessments and the policy supports that promote their use to change instruction, focusing on elementary school mathematics. The study looked at how 45 elementary school teachers in a purposive sample of 9 schools in 2 districts used interim assessments in mathematics in 2006-07. The study focused on teachers\u27 use of data in a cycle of instructional improvement; that is, how teachers gather or access evidence about student learning; analyze and interpret that evidence; use evidence to plan instruction; and carry out improved instruction. Authors conclude that interim assessments that are designed for instructional purposes are helpful but not sufficient to inform instructional change

Sex ratio bias and shared paternity reduce individual fitness and population viability in a critically endangered parrot

Sex‐biased mortality can lead to altered adult sex ratios (ASRs), which may in turn lead to harassment and lower fitness of the rarer sex and changes in the mating system. Female critically endangered swift parrots (Lathamus discolor) suffer high predation while nesting due to an introduced mammalian predator, the sugar glider (Petaurus breviceps). High predation on females is causing severe population decline alongside strongly biased adult sex ratios (≥73% male). Our 6‐year study showed that 50.5% of critically endangered swift parrot nests had shared paternity although the birds remained socially monogamous. Shared paternity increased significantly with the local rate of predation on breeding females, suggesting that rates of shared paternity increased when the ASR became more biased. Nests that were not predated produced fewer fledglings as the local ASR became more male‐biased possibly due to higher interference during nesting from unpaired males. Population viability analyses showed that part of the predicted decline in the swift parrot population is due to reduced reproductive success when paternity is shared. The models predicted that the population would decline by 89.4% over three generations if the birds maintained the lowest observed rate of shared paternity. This compares with predicted population reductions of 92.1–94.9% under higher rates of shared paternity. We conclude that biases in the ASR, in this case caused by sex‐specific predation from an introduced predator, can lead to changes in the mating system and negative impacts on both individual fitness and long‐term population viability.This research was funded by an Australian Research Council Discovery Grant (DP140104202)

AP39, A Mitochondrially- Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.

This is the author's accepted manuscript. The article is published in final form in Shock, DOI: 10.1097/SHK.0000000000000478This study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially targeted donor of hydrogen sulfide (H2S) in an in vitro model of hypoxia/oxidative stress injury in NRK-49F rat kidney epithelial cells (NRK cells) and in a rat model of renal ischemia-reperfusion injury. Renal oxidative stress was induced by the addition of glucose oxidase, which generates hydrogen peroxide in the culture medium at a constant rate. Glucose oxidase (GOx)-induced oxidative stress led to mitochondrial dysfunction, decreased intracellular ATP content, and, at higher concentrations, increased intracellular oxidant formation (estimated by the fluorescent probe 2, 7-dichlorofluorescein, DCF) and promoted necrosis (estimated by the measurement of lactate dehydrogenase release into the medium) of the NRK cells in vitro. Pretreatment with AP39 (30-300 nM) exerted a concentration-dependent protective effect against all of the above effects of GOx. Most of the effects of AP39 followed a bell-shaped concentration-response curve; at the highest concentration of GOx tested, AP39 was no longer able to afford cytoprotective effects. Rats subjected to renal ischemia/reperfusion responded with a marked increase (over 4-fold over sham control baseline) blood urea nitrogen and creatinine levels in blood, indicative of significant renal damage. This was associated with increased neutrophil infiltration into the kidneys (assessed by the myeloperoxidase assay in kidney homogenates), increased oxidative stress (assessed by the malondialdehyde assay in kidney homogenates) and an increase in plasma levels of IL-12. Pretreatment with AP39 (0.1, 0.2 and 0.3 mg/kg) provided a dose-dependent protection against these pathophysiological alterations; the most pronounced protective effect was observed at the 0.3 mg/kg dose of the H2S donor; nevertheless AP39 failed to achieve a complete normalization of any of the injury markers measured. The partial protective effects of AP39 correlated with a partial improvement of kidney histological scores and reduced TUNEL staining (an indicator of DNA damage and apoptosis). In summary, the mitochondria-targeted H2S donor AP39 exerted dose-dependent protective effects against renal epithelial cell injury in vitro and renal ischemia-reperfusion injury in vivo. We hypothesize that the beneficial actions of AP39 are related to the reduction of cellular oxidative stress, and subsequent attenuation of various positive feed-forward cycles of inflammatory and oxidative processes.National Institutes of Healt

Archives Magazine, 2021

Issue #2, Spring 202

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk