MEMETIC ALGORITHM WITH MULTI-PARENT CROSSOVER (MA-MPC) FOR MULTI-OBJECTIVE NETWORK DESIGN

In many Evolutionary Algorithms (EAs), a crossover with two parents is commonly used to produce offsprings. Interestingly, we need not restrict ourselves to two-parent crossover since EA allows us to emulate natural evolution in a more flexible fashion. There are experimental results in the literature which show that multi-parent crossover operators can achieve better performance than traditional two-parent versions. However, most of these experimental results are based on common test functions. Experimental studies involving real-life, NP-hard problems such as network design problem are very rare. This paper presents Memetic Algorithm with Multi-Parent Crossover (MA-MPC) with a view to providing a case study of multi-parent crossover within the framework of MA for network topology design problem. Results show that MA-MPC does not always outperform MA. It depends on the size of the problem and the number parents (be it 3, 5, 7, or any other

GROWTH RESPONSE OF MAIZE (ZEA MAYS L.) TO METAL TOXICITY

This study evaluated the phytotoxic effects of lead (Pb) and zinc (Zn) as Pb(NO3)2  and Zn(NO3)2 on maize  (Zea mays L) considering the  plants’ growth indices, biomass as well as soil parameters and soil microorganisms after treatment. The results showed that plant growth significantly reduced with increasing concentrations (100,150 and 200 mgkg-1) of Pb and Zn contamination. The results indicated significant inhibitory effect on the growth parameters (stem height, root length, leaf area, fresh and dry weight) measured, compared to control experiment. This study therefore revealed that the heavy metals have harmful effects on maize’s growth.  Consequently, the consumption of such contaminated cereal by man and animals can lead to their death after the metals have biomagnified in their systems. Lead and Zn application in general, affected the vegetative growth; both fresh and dry weights were reduced with increasing concentrations of the metals. These results show that these metals are toxic to human and animal health. As a result, farmers should be encouraged to use water from good source for irrigation and also cultivate on metal-free soils if possible to save lives.     &nbsp

An overview of some medicinal plants and isolated active compounds with potential antiprotozoal activity

Diarrhoea associated illness presents with mortality and morbidity in rural communities in most low income countries especially in children < 5 years of age. The continuous emergence of several opportunistic infections in immuno-compromised individuals has worsened the burden of diarrhoea in most of these countries. Protozoan infections caused by species of Cryptosporidium, Entamoeba spp. Giardia intestinalis, Blastocystis hominis and Trichomonas vaginalis have received insufficient attention because data on their prevalence and incidence are scanty. The commonly used drugs to treat infections caused by these organisms are becoming less effective due to the development of drug resistance. Evidence from literature has shown that natural products from medicinal plants are likely to be suitable alternatives and complimentary therapeutic drugs to combat most protozoan infections. Natural products and their bioactive compounds could be the solution to treat most protozoan infections that have developed resistance to these drugs. This review provides comprehensive information on the potential and limitations on activity of medicinal plants and their isolated compounds used in the treatment of protozoan diseases. Especially those considered as neglected diseases such as Cryptosporidium and other protozoans that are inadequately funded and possibility of lack of interest in drug developments have made them  receive little attention. Isolation and identification of bioactive natural products could be the ultimate panacea to cases of metronidazole resistance and discovery of effective and novel drug for Cryptosporidium infection which is currently suffering inadequate treatment options. Keywords: Protozoan parasites, Diarrhoea, Neglected diseases, Medicinal plants, Bioactive compound

THRESHOLD-BASED BANDWIDTH ALLOCATION SCHEME FOR MULTISERVICE WIRELESS NETWORKS

Priority Queuing with Buffer Management (PQBM) has been recently proposed in the literature. The protocol is acclaimed to be a very attractive candidate in current (2.5G and 3G) and next (4G) multiservice wireless networks. However, it suffers bandwidth monopolization by higher priority data packets. This paper proposes a new scheme namely Improved Priority Queuing with Buffer Management (IPQBM) with a view to redistributing service provision to the data classes optimally. In particular, the scheduling discipline of PQBM is modified so as to correct the monopoly problem. IPQBM is compared with PQBM vis-à-vis throughput and mean delay of data packets. Numerical results reveal that IPQBM offers improved throughput for lower priority data packets by ensuring that higher priority data class does not have a monopoly of bandwidth resources

Ethnoveterinary survey of tradomedical importance of Bos taurus L urine, bile and dung in Nigeria and South Africa

Purpose: To evaluate the ethnoveterinary uses of cow by-products from Nigeria and South Africa.Methods: A field survey was conducted from January to September, 2015 by conducting interviews with 110 respondents who provided information in respect of the use of cow urine, bile and dung in their folk medicine in Nigeria and South Africa.Results: Most respondents opined that urine therapy is effective in treating convulsion (50 %), viral infections (29.2 %), and rheumatic arthritis (14.6 %) in Nigeria. In South Africa respondents are of the view that urine is highly effective (28.6 %) in treating diarrhoea while 14.3 % stated that urine can treat fever, sore throat, skin infections. Bile is commonly used in treating general body pain and high blood pressure in Nigeria and used for skin burns in South Africa. Cow dung is specifically used in both countries as pesticides, fertilizers, anti-toxins and treating skin infections. This study documents the ethnoveterinary uses of B. taurus by products by traditional practitioners in Nigeria and South Africa.Conclusion: There is need for further studies to validate the therapeutic potential of these products with regards to each of the ailments listed and isolation of the bioactive compounds in African species of B. taurus by-products.Keywords: Ethnoveterinary, Urine, Bile, Dung, Bos taurus, Tradomedical, Folk medicine, Field surve

Comparative analysis of SVM and logistic regression for classifying diagnostic microRNA signatures in colorectal cancer

Abstract The selection and classification of genes are critical for determining which ones are linked to a particular illness, especially cancer. As a result, it's critical to use machine learning algorithms to analyze relevant statistical data to aid biomedical researchers and end-users in the work of selection and classification. Few researches have been done on the early diagnosis of CRC using machine learning techniques to detect biomarkers, which are very important in colorectal cancer disease diagnoses. We therefore conduct a comprehensive gene selection and classification functionality using SVM and Logistic Regression algorithms on high-dimensional datasets. The results show that under the receiver operating characteristic (ROC) curve, the SVM and Logistic Regression models' discriminative capacities for classification were 83.5% and 73.2 %, respectively. This study thus reveals that the SVM algorithm outperforms the Logistic Regression algorithm in classifying data in the detection of Colorectal Cancer.             Keywords: Algorithm, Biomarkers, Classification, Colorectal Cancer, Disease Diagnosi

Willingness of Herbal Medicine Practitioners and Herbs Vendors to Contribute Financially to Conservation of Medicinal Plants in Ibadan, Nigeria

Erratum: The earlier version of this paper had some errors. It included references of later than 2014, the year of its publication. These references have been removed in the whole document and replaced with others of 2014 or earlier. Further, in paragraph 1 of the Discussion, after the sentence starting with Male…, the following statement “In contrast, studies in China showed that 59.8%of acupuncturists were females (Robinson et al., 2012)” has been inserted to replace the previous one. In paragraph 6 of Discussion, the words “capita income of $2,748 in 2010. Currently, the poverty level in Nigeria is 83.9% (Akinboade, 2010).” have been added to replace previous text. In paragraph 7 of the Discussion, the words “plants, provide employment” have been added after the word “medicinal” to replace previous text. This is therefore the correct version.The study evaluated the willingness of Herbal Medicine Practitioners (HMPs) and Herb Vendors (HVs) in Ibadan, Nigeria to contribute financially to medicinal plants conservation projects. Data was collected using structured questionnaires administered on 124 HMPs and 83 HVs randomly selected from fourteen herbal associations and marketers respectively. Results showed that 79.03%of all HMPs were males and 20.97% females while 83.13% of HVs were females and 16.87% males. All the HMPs and 97.59% of HVs were willing to contribute financially and provide useful information to conservation projects. Majority (54.84%) of the interviewed HMPs were willing to contribute between N500 - N1500 annually while most of the HVs (51.8%) were willing to contribute between N201 - N500 annually. Lack of financial power and land were identified as major constraints to holding private gardens. A total of 38 commonly used medicinal plant species was identified in the existing small scale private gardens of HMPs. There is need to organise the HMPs and HVs into formidable cooperative societies for easy access to fund and institute awareness campaign on the need for conservation of important local medicinal plants if the health for all dream is to be achieved

Effects of Garlic Feed Inclusion on Experimental Salmonella gallinarum Infection in Broiler Chickens (Gallus gallus domesticus)

Garlic is a spice and herbal medicine with antibacterial, antioxidant and immunomodulatory effects. In view of global demand for reduction in antibiotic use in poultry production, the potential of garlic at controlling fowl typhoid was investigated. Day-old (75) broiler chicks were separated into groups A, B, C, D and E of fifteen each, placed in cages for brooding and administered 0.125%, 0.25%, 0.5%, 0% and 0.125% garlic-meal, respectively, in feed. At 9 week-old, each chick in groups A, B, C and D were inoculated with 8x106 cfu/ml PBS of Salmonella gallinarum, orally, while those in Group E were given PBS only. Up till 10 days post-infection (pi), clinical signs were scored from 1-3 based on degree of severity i.e. 1(mild), 2 (moderate) and 3 (severe). Mortality and gross pathology per group were recorded. Samples from liver and gall bladder were harvested for bacterial re-isolation. Groups A, B and C showed mild diarrhoea while group D showed in addition, anorexia, ruffled feathers and unthriftiness. Diarrhoea in groups A and B spanned days 2 -7 pi, group C on day 3 pi while in group D, days 1-10 pi with increasing degree of severity. Total diarrhoea scores were 6(A), 4(B), 1(C), 23(D) and 0(E) while mortalities were 2(A), 0(B), 2(C), 4(D) and 0(E). Enlarged and congested/bronze-coloured liver, engorged gall bladder and catarrhal enteritis were observed in carcasses. Colonial and cellular morphology of re-isolated bacteria were typical of S. Gallinarum. Garlic-meal ameliorated the effects of S. Gallinarum infection with the best result at 0.25%. Keywords: broiler chickens; antibacterial; fowl typhoid; Garlic; Salmonella gallinaru

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.publishedVersionFil: Oladele, Johnson O. Kings University; Nigeria.Fil: Ajayi, Ebenezer Idowu O. Osun State University; Nigeria.Fil: Ajayi, Ebenezer Idowu O. Universidad Nacional de Córdoba. Rectorado; Argentina.Fil: Ajayi, Ebenezer Idowu O. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra.; Argentina.Fil: Oyeleke, Oyedotun M. Kings University; Nigeria.Fil: Oladele, Oluwaseun T. Osun State University; Nigeria.Fil: Olowookere, Boyede D. Kings University; Nigeria.Fil: Adeniyi, Boluwaji M. Benue State University; Nigeria.Fil: Oyewole, Olu I. Osun State University; Nigeria.Fil: Oladiji, Adenike T. University of Ilorin; Nigeria