Antimalarial natural products from some Cameroonian medicinal plants

No Abstract.Journal of the Cameroon Academy of Sciences Vol. 5 (Supplement) 2005: pp. 65-7

7,8-dimethoxy-n-methylflindersine and 7,8-dimethoxy-3-(3-methylbut-2-enyl)-2-quinoline: antimalarial constituents of Araliopsis tabouensis

7,8-dimethoxy-N-methylflindersine and 7,8-dimethoxy-3-(3-methylbut-2-enyl)-2-quinoline were isolated from the stem bark of Araliopsis tabouensis and their structures were assigned base on their 1H and 13C-NMR, DEPT 135, Gradient HMBC, G-HMQC and G-DQF-Cosy characteristics. The IC50 value in antimalarial bioassays vary from 1.8 to 4.7 μg/ml. Key words: Araliopsis tabouensis, structural determination, antimalarial properties. Journal of Pharmaceutical and Allied Sciences Vol.2(2) 2005: 214-21

Indoloquinazoline alkaloids from Araliopsis tabouensis

Three new indoloquinazolidine-type alkaloids, 2-methoxy-8-13-dihydro-7H-indolo[pyrido[2,1-b]quinazolin-5-one (1) , 2-methoxy-13-methyl-8-13-dihydro-7H-indolo[2',3',3,4]pyrido[2,1-b]quinazolin-5-one (2) , and 2-methoxy-14-methyl-7,8,13,14-tetrahydroindolo[2',3',4]pyrido[2,l-b]quinazolin-5-one (3) were isolated from Araliopsis tabouensis, together with three known compounds. The structures of the new compounds were determined primarily from 1D- and 2D-NMR spectroscopy. The antimalarial activities of compounds 1-5 were evaluated against Plasmodium falciparum D6 and W2 clones. The IC50 values in antimalarial bioassay for compounds 2-5 varied from 1.8 to 4.7 μg/ml. Nig. J. Pharm. Res. 3(1) 2004: 42-4

Screening of traditionally used Tanzanian medicinal plants for antifungal activity

Kisangau DP, Hosea KM, Lyaruu HVM, et al. Screening of traditionally used Tanzanian medicinal plants for antifungal activity. PHARMACEUTICAL BIOLOGY. 2009;47(8):708-716.Fungal infections represent a significant cause of morbidity and mortality especially in immunocompromised patients in the world today. Dichloromethane (DM) and aqueous (W) extracts of nine plants used traditionally for the treatment of fungal infections in Bukoba rural district in Tanzania were screened for antifungal activity against Candida albicans, Cryptococcus neoformans, and Aspergillus niger using agar well and disk diffusion methods. Dichloromethane extracts of Capparis erythrocorpos [CE] Isert (Capparaceae), Cussonia arborea [CA] Hochst. Ex A. Rich (Araliaceae), Drocaena steudneri [DS] Engl. (Dracaenaceae), Lannea schimperi [LS] (A. Rich) Engl. (Anacardiaceae), Rouvolfia vomitoria [RV] Afz (Apocynaceae), and Sapium ellipticum [SE] (Krauss) Pax (Euphorbiaceae) showed activity against all three fungi. Extracts of Rumex usambarensis [RU] (Dammer) Dammer (Polygonaceae) and Zehneria scabro [ZS] (L.f.) Sond. (Cucurbitaceae) had an activity limited to only one or two of the test organisms. Rhoicissus tridentata [RT] (L.Q Wild & Drum (Vitaceae) was the only plant without activity. Fractions of the active extracts CE, CA, DS, LS, and SE exhibited higher antifungal activity against one or more of the three fungi. Four compounds isolated from S. ellipticum also exhibited antifungal activity against one or more of the three fungi. The minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs), determined using the microplate assay method, ranged between 0.4 and 50.0 mu g/mL for crude extracts, 1.6 and 50.0 mu g/mL for semi-purified fractions, and 0.12 and 1.0 mu g/mL for pure compounds, as compared to 0.016-1.5 mu g/mL for fluconazole. We confirm the potential of traditionally used plants as a source of new drugs for treatment of fungal infections