Relationship Between Atopy Patch Test with Foods and SCORAD

Background and Design: The relationship between food and atopic dermatitis (AD) is controversial. Atopy patch test (APT) gained prominence due to low specificity of “fresh prick tests” (FPT) with foods, commonly late occurrence of lesions in AD and, thus, the inconsistencies in anamneses, and being the provocative tests time consuming and risky, as well as due to the role of T lymphocytes in the pathophysiology of the disease. In this study, we investigated the relationship of APT and FPT made with food with SCORAD index assessing the disease severity.Materials and Methods: Forty-five children (21 males and 24 females) aged between 2-15 years who were diagnosed with AD in our outpatient clinic between May 2006 and May 2007 were included in the study. FPT and APT with eggs, milk and wheat flour were performed in all patients. The severity of illness was assessed using the SCORAD index. Statistical analysis was performed using SPSS version 11.0 for Windows. A p value of less than 0.05 was considered statistically significant

Brucella peritonitis in a patient on continuous ambulatory peritoneal dialysis with acute brucellosis

Peritonitis is an uncommon complication of brucellosis. Brucella peritonitis in chronic ambulatory peritoneal dialysis (CAPD) patients has not been reported before. A male patient is presented with peritonitis caused by Brucella melitensis who was on CAPD. The source of infection was thought to be unpasteurized, unsalted cheese eaten a month before the onset of symptoms. At the beginning, antibiotic therapy with doxycyline and rifampicin led to a rapid clinical improvement, with disappearance of the organism in the peritoneal fluid. However, peritonitis relapsed after discontinuation of antimicrobial therapy. Successful management required a combination of medical therapy and removal of the Tenckhoff catheter. Copyrlight (C) 2002 S. Karger AG, Basel

Hereditary angioedema

Herediter anjiyoödem, fatal larinks ödemine ve gastrointestinal sistem tıkanıklığına benzeyen bulgulara yol açabilen, tekrarlayıcı anjiyoödem ataklarıyla karakterize, nadir görülen, otozomal dominant geçişli bir hastalıktır. Atakları sıklıkla travma, stres, hormonal tedaviler ve ACE inhibitörleri tetikler. Tanı, C4 ve C1 inhibitör düzeylerindeki düşüklüğün ve C1 inhibitör fonksiyonundaki azalmanın gösterilmesiyle konur. Hastalığın profilaktik tedavisinde atenüe androjenler ve traneksamik asit kullanılır. Akut atakların tedavisinde C1 inhibitör konsantresi infüzyonu tercih edilen tedavi yöntemidir. Bu konuda genetik mühendislik yöntemiyle üretilen C1 inhibitör; kallikrein inhibitörü ve bradikinin reseptör antagonistleriyle ilgili çalışmalar devam etmektedir.Hereditary angioedema is a rare autosomal dominant disease characterized by recurrent episodes of angioedema which can cause fatal laryngeal oedema and features mimicking gastrointestinal tract obstruction. Attacks are usually precipitated by trauma, stress, hormonal therapy and ACE inhibitors The diagnosis is confirmed by the presence of a low serum C4 and reduced C1 inhibitor level or function. Attenuated androgens and tranexamic acid are used for the prophylactic treatment of the disease. C1 inhibitor concentrate infusion is the treatment of choice for acute attacks. There are new products in trial, including genetically engineered C1 esterase inhibitor, kallikrein inhibitor and bradykinin B2 receptor antagonist