Malignant ameloblastoma: a challenging diagnosis

Ameloblastoma is an uncommon and locally aggressive, benign, odontogenic tumor, with local recurrence when not adequately excised. A rare variant of this neoplasm with the benign features but accompanied with metastases has been described. This rare variant is malignant ameloblastoma and is known to have a poor prognosis. We present the case of a young woman who had recurrent mandibular tumors, which were resected twice and histologically reported as ameloblastoma. Four years later, she presented with pulmonary metastasis and atelectasis. A review of the literature on this very rare neoplasm was also performed

Pandemic swine influenza virus: Preparedness planning

The novel H1N1 influenza virus that emerged in humans in Mexico in early 2009 and transmitted efficiently in the human population with global spread was declared a pandemic strain. The introduction of different avian and human influenza virus genes into swine influenza viruses often result in viruses of increased fitness for pigs that occasionally transmit to humans.The novel virus affecting humans is derived from a North American swine influenza virus that has acquired two gene segments (Neuraminidase and Matrix ) from the European swine lineages. This reassortant appears to have increased fitness in humans. The potential for increased virulence in humans and of further reassortment between the novel H1N1 influenza virus and oseltamivir resistant seasonal H1N1 or with highly pathogenic H5N1 influenza stresses the need for urgent pandemic planning.Keywords: Pandemic, swine, influenza, virus, preparedness

The Association between HIV Infection, Antiretroviral Therapy and Cervical Squamous Intraepithelial Lesions in South Western Nigerian Women.

Findings from studies that evaluated the effect of antiretroviral drug use on the development of cervical squamous intraepithelial lesion differed in their conclusions. This study investigated the association between HIV infection, antiretroviral drug use and cervical squamous intraepithelial lesion in a high HIV and cervical cancer burden setting- Nigeria

Malignant ameloblastoma

Ameloblastoma is an uncommon and locally aggressive, benign, odontogenic tumor, with local recurrence when not adequately excised. A rare variant of this neoplasm with the benign features but accompanied with metastases has been described. This rare variant is malignant ameloblastoma and is known to have a poor prognosis. We present the case of a young woman who had recurrent mandibular tumors, which were resected twice and histologically reported as ameloblastoma. Four years later, she presented with pulmonary metastasis and atelectasis. A review of the literature on this very rare neoplasm was also performed

Proliferaton index in pituitary adenomas from a black African population

Background: The WHO has recognized a variant of pituitary adenomas with potential aggressive behaviour which have been termed atypical pituitary adenomas. This group of tumours are recognized by their mitotic rate of more than >3%, p53 expression and invasion of surrounding structures. There has however been no study of the occurrence of these tumours in a black African population. This study is a preliminary attempt to examine this group of tumours in blacks.Methods: This study retrospectively reviewed fifty-seven histologically diagnosed and immunohistochemically characterized pituitary adenomas received in our department over a twenty-one year period. Specimens were stained with ki67, a nuclear marker of cell proliferation which has been identified as the single best predictor of atypical pituitary adenoma.Results: Twelve of the tumours showed atypical features with eight (67%) of these tumours being prolactinomas. Two of the tumours were gonadotrophs and two were null cell adenomas. There was no correlation with age or gender. Two of the tumours required neurosurgical re-exploration with one of these showing a higher mitotic index in the second biopsy.Conclusion: The study suggests similarity in the rate of occurrence of pituitary adenomas with atypical features in a black African population with what is seen in Caucasians. Prolactinomas constitute a significant percentage of the tumours with this feature.Keywords: Pituitary adenoma, Immunohistochemistry, Atypical, Ki6

Human papillomavirus infection in women with and without cervical cancer in Ibadan, Nigeria

<p>Abstract</p> <p>Background</p> <p>Concerns have been raised that the proportion of cervical cancer preventable by human papillomavirus (HPV) 16/18 vaccines might be lower in sub-Saharan Africa than elsewhere.</p> <p>Method</p> <p>In order to study the relative carcinogenicity of HPV types in Nigeria, as well as to estimate the vaccine-preventable proportion of invasive cervical cancer (ICC) in the country, we compared HPV type prevalence among 932 women from the general population of Ibadan, Nigeria, with that among a series of 75 ICC cases diagnosed in the same city. For all samples, a GP5+/6+ PCR based assay was used for the detection of 44 genital HPV types.</p> <p>Results</p> <p>In the general population, 245 (26.3%, 95% confidence interval (CI) 23.5% - 29.2%) women were HPV-positive, among whom the prevalence of HPV35 and HPV16 were equally frequent (12.2%, 95% CI 8.4% - 17.0%). In ICC, however, HPV16 predominated strongly (67.6% of 68 HPV-positive cases), with the next most common types being 18 (10.3%, 95% CI 4.2% - 20.1%), 35, 45 and 56 (each 5.9%, 95% CI 1.6% - 14.4%). Comparing among HPV-positive women only, HPV16 and 18 were over-represented in ICC <it>versus </it>the general population (prevalence ratios 5.52, 95% CI 3.7 - 8.3 and 1.4, 95% CI 0.6 - 3.3, respectively). Other high-risk HPV types, as well as low-risk and multiple HPV infections were less common in HPV-positive women with ICC than from the general population.</p> <p>Conclusions</p> <p>Our study confirms that in Nigeria, as elsewhere, women infected with HPV16 and 18 are at higher risk of developing ICC than those infected with other high-risk types, and that current HPV16/18 vaccines have enormous potential to reduce cervical cancer in the region.</p

Postharvest Preservation Technology of Cereals and Legumes

Cereals and legumes are prone to perishability and have very short shelf-life if not given proper treatment. During different handling and marketing operations, there is a huge postharvest loss of agricultural produce. The qualitative and quantitative losses incurred in cereals and legumes commodities between harvest and consumption are huge. Qualitative losses such as loss inedibility, nutritional quality, calorific value, and consumer acceptability of fresh produce are much more difficult to assess than are quantitative losses. The major cause of postharvest loss (PHL) is the availability of poor infrastructure for postharvest technology (PHT) and processing of commodities. These losses can only be minimized by proper handling, marketing, and processing of the agricultural commodities; as well as the use of modern preservation technologies such as irradiation, radio frequency heating, etc. The sufficient knowledge of pre-and post-harvest preservation technologies and the provision of adequate and sufficient storage facilities for cereals and legumes handling and distribution would help to mitigate the incidence of postharvest deterioration and therefore improve the availability of cereals and legumes in the market and subsequent reduction in malnutrition for increased food security. Postharvest preservation technology of cereals and legumes is very fundamental in reducing postharvest losses and increasing food security

Kidney disease in hepatitis B surface antigen-positive children: experience from a centre in south-west Nigeria and a review of the Nigerian literature

Kidney disease is an important extra-hepatic manifestation of hepatitis B virus (HBV) infection. However, there is paucity of recent literature on kidney disease in children and adolescents with HBV infection from several parts of sub-Saharan Africa including Nigeria.To review the pattern of kidney disease in hepatitis B surface antigen (HBsAg)-positive children and adolescents seen at a tertiary hospital in south-west Nigeria.A retrospective study was undertaken of HBsAg-seropositive children with kidney disease managed at University College Hospital, Ibadan, from January 2004 to December 2015. Patients were identified from the paediatric nephrology unit admissions and the renal histology registers.24 children and adolescents were studied, 17 of whom were male (70.8%), and the median age was 10.0 years (range 3-15). Ten (41.7%) had nephrotic syndrome, five (20.8%) had non-nephrotic glomerulonephritis, five (20.8%) were in end-stage renal disease (ESRD), including a patient with posterior urethral valves, and four had acute kidney injury secondary to acute tubular necrosis. Renal histology was available for 10 patients: nine had nephrotic syndrome associated with minimal change disease in six, focal segmental glomerulosclerosis in two and one had membanoproliferative glomerulonephritis. The patient with non-nephrotic glomerulonephritis had diffuse global sclerosis.The pattern of kidney disease in HBV-positive children demonstrated a predominance of nephrotic syndrome, followed by non-nephrotic glomerulonephritis, ESRD and acute kidney injury. Better diagnostic facilities and treatment are required. Prevention of HBV infection by universal childhood immunisation is the ultimate goal

Processing of Oilseeds in the Tropics: Prospects and Challenges

Oilseeds have been cultivated from antiquity with increasing demand in agricultural industries world trade. Many economies such as Malaysia depend largely on oilseed crops which are grown primarily for the edible oil production; and for additional meal fraction arising from the seed. The meal is rich in protein and used for animal feed. Recent developments in research have posited oilseeds as a viable source for the production of biodiesel. In the tropics, most of the oilseeds are underutilized; and interest in its mass production and utilization are lacking. Some other seed such as neem seeds, pawpaw seeds, Jatropha curcas L. seeds, etc. have not been put to use in tropical countries leading to subsistence production and their applications in other areas. The oilseed crops could be used either for human, animal or for industrial purposes. There is need to increase the volume of production of these oils in tropical countries through improved quality farming techniques that would encourage breeding in other to meet up with increasing demands. Notably, there are many conventional methods that have been used to increase oilseeds yields. However, the adoption of each technology improvement should be sustainable, while other unknown oilseeds should be discovered for increased utilization