Metal Contamination Of Foods and Drinks Consumed in Ota, Nigeria

Food consumed in Ota, Nigeria are prone to contamination with environmental metal pollutants. The concentrations of lead (Pb), cadmium (Cd), nickel (Ni), mercury (Hg), copper (Cu), manganese (Mn) and zinc (Zn) were determined in some commonly consumed foods and drinks using Atomic Absorption Spectrophotometry (AAS). Samples selected included fried yam, fried bean cake (akara), roasted plantain (bole), roasted meat (suya), roasted fish, cassava flour (fufu), yam flour (amala), garri (eba), beans and herbal drink (agbo jedi jedi). Lead was present only in roasted meat (0.02±0.02 mg kg-1), garri (0.04±0.06 mg kg-1) and roasted plantain (0.004±0.01 mg kg-1). Copper and cadmium ranged from 0.02±0.19-3.55±0.20 and 0.02±0.01-0.59±0.17 mg kg-1, respectively. The mean concentration of zinc and nickel ranged from 0.09±0.10-1.19±1.52 and 0.04±0.01-6.38±7.61 mg kg-1, respectively. The mean concentration of manganese ranged from 0.06±0.05-0.25±0.19 mg kg-1. Manganese was absent in agbo jedi jedi (ethanolic). Some of the foods including roasted plantain (bole), roasted meat (suya), roasted fish, cassava flour (fufu), yam flour (amala) and beans were contaminated with nickel above FAO/WHO tolerable limits. Agbo jedi jedi was found to be contaminated with cadmium, nickel and copper above safety levels. Mercury was present only in roasted plantain at a level of 0.91±1.28 mg kg-1 which was beyond tolerable limits. This study indicates that consumers of the foods and drinks with high levels of metal contamination may be exposed to health risks associated with their presenc

Neuropharmacological evaluation of Annona senegalensis leaves

The neuropharmacological activities of methanol leaf extract (ME) of Annona senegalensis Pers (Annonaceae) and its bioactive fractions (MF and F7) were studied in rodents using pentylenetetrazol (PTZ)-induced seizures, pentobarbitone-induced sleep, apomorphine-induced stereotypy, open field, elevated plus maze (EPM) and rotarod performance tests. The extract and fractions inhibited PTZ-induced seizures, prolonged pentobarbitone-induced sleep, reduced stereotypic behaviour induced by apomorphine, decreased the frequency of line crossing and centre square entries and increased rearing in the air in the open field. The frequency of grooming and rearing against the wall were decreased, whereas the duration of grooming increased. Also, the extract and fractions increased the duration of stay in the open arm when compared to the closed arm of the EPM, and reduced the average time spent on the rotarod. Acute toxicity test showed an oral LD50 of ME greater than 5 g/kg in mice. Phytochemical analysis showed that ME tested positive for carbohydrates, reducing sugar, resins, saponins,  tannins, steroids, terpenoids, alkaloids, flavonoids and glycosides; MF tested positive for saponins, steroids, terpenoids, alkaloids, carbohydrates, reducing sugar, flavonoids and glycosides; while F7 tested positive for flavonoids. These findings suggest that leaves of A. senegalensis possess anticonvulsant, central depressant and anxiolytic-like properties attributable to flavonoids.Keywords: Annona senegalensis, anticonvulsant, anxiolytic, sedative, stereotypy

Effect of Nanoparticles in Drilling Fluids on the Transportation of Different Cutting Sizes in a Rotating Horizontal Pipe

: Cutting transport is difficult in horizontal borehole regions due to the limited axial velocity distribution. This causes transported cuttings to gravitate to the bottom, generating cutting beds and leading to drilling mishaps. Water-based mud (WBM) that includes nanoparticles (NPs) to determine the cutting transport ratio (CTR) performance using copper II oxide (CuO), aluminium oxide (Al2O3), magnesium oxide (MgO), and silicon dioxide (SiO2) in a horizontal borehole needs further investigation. These NPs ability to transport 0.80–3.60 mm cutting sizes was tested using concentrations of 1.0 and 2.0 g circulated through a horizontal annulus at 3.5 m/s and 120 rpm. With 2.0 g, MgO lowered the viscosity by 60%, whereas SiO2, CuO, and Al2O3 increased it by 49%, 10%, and 87%, respectively. CuO NP decreased the fluid loss (FLAPI) the best, followed by MgO, SiO2, and Al2O3. The FLAPI of the WBM, which was 9.4 mL, dropped to 4.8, 5.1, 7.4, and 8.2 mL with CuO, MgO, SiO2, and Al2O3 NPs, respectively. The CTR performance of the NPs increased with concentration and decreased with increasing cutting size. CuO, having less viscosity than Al2O3 and SiO2, carried the most cutting at all concentrations and sizes. It increased the CTR by 28.8–31.1%, whereas Al2O3 and SiO2 increased it by 22.7–26.7% and 16.7–22.2%, respectively. The lowest increase was 13.6–17.8% for MgO NP. This study demonstrates the favourable impact of NP concentrations on the performance of drilling fluids while presenting many choices for the selection of NPs

Unravelling factors associated with malaria parasitaemia among children 6–24 months to inform malaria interventions in Nigeria: evidence from 2021 Malaria Indicator Survey

Abstract Background As an additional two million malaria cases were reported in 2021 compared to the previous year, concerted efforts toward achieving a steady decline in malaria cases are needed to achieve malaria elimination goals. This work aimed at determining the factors associated with malaria parasitaemia among children 6–24 months for better targeting of malaria interventions. Methods A cross-sectional study analysed 2021 Nigeria Malaria Indicator Survey dataset. Data from 3058 children 6–24 months were analyzed. The outcome variable was children 6–24 months whose parasitaemia was determined using a rapid diagnostic test (RDT). Independent variables include child age in months, mothers’ age, mothers’ education, region, place of residence, household ownership and child use of insecticide-treated net (ITN), exposure to malaria messages and knowledge of ways to prevent malaria. Logistic regression analysis was conducted to examine possible factors associated with malaria parasitaemia in children 6–24 months. Results Findings revealed that 28.7% of the 3058 children aged 6–24 months tested positive for malaria by RDT. About 63% of children 12–17 months (aOR = 1.63, 95% CI 1.31–2.03) and 91% of children 18 to 24 months (aOR = 1.91, 95% CI 1.51–2.42) were more likely to have a positive malaria test result. Positive malaria test result was also more likely in rural areas (aOR = 1.79, 95% CI 2.02–24.46), northeast (aOR = 1.54, 95% CI 1.02–2.31) and northwest (aOR = 1.63, 95% CI 1.10–2.40) region. In addition, about 39% of children who slept under ITN had a positive malaria test result (aOR = 1.39 95% CI 1.01–1.90). While children of mothers with secondary (aOR = 0.40, 95% CI 0.29–0.56) and higher (aOR = 0.26, 95% CI 0.16–0.43) levels of education and mothers who were aware of ways of avoiding malaria (aOR = 0.69, 95% CI 0.53–0.90) were less likely to have a malaria positive test result. Conclusion As older children 12 to 24 months, children residing in the rural, northeast, and northwest region are more likely to have malaria, additional intervention should target them in an effort to end malaria

Assessment of Mycoflora of Poultry Feed Raw Materials

Abstract: The study was carried out to identify the common moulds growing in the selected feed raw materials in Owerri, Imo State, Nigeria. Fifty-four bulk samples were derived from 162 bags of 6 different raw materials, which included local fish meal (LFM), soybean meal (SBM), groundnut cake (GNC), palm kernel cake (PKC), brewers dried grain (BDG) and maize (MZ). The samples were collected during the rainy season months of June, July and August. The common moulds isolated from these samples were Mucor spp., Aspergillus spp., Yeast spp., Bacteria spp and Rhizopus spp. More fungal organisms were isolated in the month of July although Aspergillus spp was not isolated during the month. Local fishmeal, palm kernel cake, and brewers dried grain had the highest isolates of three organisms each with the prevalence ranging from 13.64 to 18.18%. Soybean meal, maize and groundnut cake on the other hand returned between one and two isolates. The present result showed that untreated feed raw materials are important vehicles for introduction of fungal organisms into poultry feed. It is therefore, advised to routinely treat such feed raw materials with fungal growth inhibitors in order to limit their growth since these organisms are capable of reducing the nutritional values of finished feeds

Nutritional Composition of African Star Apple (Chrysophyllum albidum) Seed obtained from Tunga Market in Minna, Niger State, Nigeria

The nutritional composition of Africa star apple seeds (Chrysophyllum albidum) was carried out. This sample seed was obtained from Tunga Market, Minna Niger State, Nigeria. The proximate compositions (crude fats, proteins, ash, fiber, moisture, carbohydrate), minerals (phosphorous, potassium, calcium, sodium, and magnesium), and contents were determined using standard methods. For sample AS1, The moisture content yields 6.49%, crude ash 2.25%, fats yield 5.64%, crude fiber 0.84%, crude protein 10.50%, and carbohydrate content 74.28%. As for the AS2 sample, the moisture content yields 6.42%, crude ash 2.21%, fats 5.66%, crude fiber 0.81%, crude protein 10.50%, and carbohydrate content 74.30%. The AS1 sample had 92.36, 38.64, 229.10, 63.44,108.50/100g of calcium, magnesium, sodium, potassium, and phosphorous respectively. Likewise, the AS2 sample had 90.58, 36.82, 28.64, 65.20,112.30/100g respectively. The seeds had a high concentration of minerals. The seed had significant levels of both essential and non-essential amino acids, and the values of anti-nutrients that were measured were below the accepted benchmark, allowing for safe consumption. The findings indicate that eating African star apple seeds will significantly help meet human nutritional needs for proper growth and provide appropriate protection from diseases brought on by malnutrition

COVID-19 Vaccine Hesitancy and Determinants of Acceptance among Healthcare Workers, Academics and Tertiary Students in Nigeria

The COVID-19 pandemic has resulted in millions of human deaths, prompting the rapid development and regulatory approval of several vaccines. Although Nigeria implemented a COVID-19 vaccination program on 15 March 2021, low vaccine acceptance remains a major chal-lenge. To provide insight on factors associated with COVID-19 vaccine hesitancy (VH), we conducted a national survey among healthcare workers, academics, and tertiary students, between 1 September 2021 and 31 December 2021. We fitted a logistic regression model to the data and exam-ined factors associated with VH to support targeted health awareness campaigns to address public

Amphipathic anionic surfactant modified hydrophilic polyethylene glycol-nanosilica composite as effective viscosifier and filtration control agent for water-based drilling muds

Highly stabilized and dispersible composites of polyethylene glycol and silica nanoparticle in aqueous drilling mud can provide desirable rheological and filtration properties for drilling jobs. Therefore, high-quality hydrophilic polyethylene glycol-nanosilica composite modified by amphipathic anionic sodium dodecyl sulfate (PEG-SiO2 NC-SDS) to improve the rheological and filtration properties of water-based muds (WBMs) was submitted. Test of zeta potential, functional groups, morphology, elemental composition, and temperature stability together with rheology and filtration tests were undertaken to assess the wide-ranging mud properties of the SDS modified PEG-SiO2 NC drilling muds. Zeta potential, FTIR, FESEM, EDX, and TGA results indicate that the SDS modified PEG-SiO2 NC was effectively formed and modified, it embodies exceptional thermal stability and is efficiently dispersed. The SDS modified PEG-SiO2 NC has a narrow size distribution range between 82 nm and 410 nm, and a specific surface area of 41.4 m2/g that is sufficiently high for particle-molecule interactions. Its rheological variables are notably shear-thinning and did not undergo notable fluctuation. The filtrate loss of 1.5 g SDS bearing PEG-SiO2 NC at 78 °F and 250 °F was only 5.4 ml and 9.6 ml, against 10.2 ml and 20.5 ml of the WBMs, respectively. High dispersion stability and high thermal stability aided its excellent viscosity and filtration control performance. Moreover, optimum rheological properties for the SDS modified PEG-SiO2 NC drilling muds with Bingham plastic and Ostwald-de-Waele models occurred with mud composition CD3 (CD3 = 1.5 g SDS modified PEG-SiO2 NC + WBM). Thus, this study can help to understand the applications of this nanocomposite as a potential viscosifier and filtrate loss control material for WBMs

Improving equity in malaria treatment: Relationship of socio-economic status with health seeking as well as with perceptions of ease of using the services of different providers for the treatment of malaria in Nigeria

<p>Abstract</p> <p>Background</p> <p>Equitable improvement of treatment-seeking for malaria will depend partly on how different socio-economic groups perceive the ease of accessing and utilizing malaria treatment services from different healthcare providers. Hence, it was important to investigate the link between socioeconomic status (SES) with differences in perceptions of ease of accessing and receiving treatment as well as with actual health seeking for treatment of malaria from different providers.</p> <p>Methods</p> <p>Structured questionnaires were used to collect data from 1,351 health providers in four malaria-endemic communities in Enugu state, southeast Nigeria. Data was collected on the peoples' perceptions of ease of accessibility and utilization of different providers of malaria treatment using a pre-tested questionnaire. A SES index was used to examine inequities in perceptions and health seeking.</p> <p>Results</p> <p>Patent medicine dealers (vendors) were the most perceived easily accessible providers, followed by private hospitals/clinics in two communities with full complement of healthcare providers: public hospital in the community with such a health provider and traditional healers in a community that is devoid of public healthcare facilities. There were inequities in perception of accessibility and use of different providers. There were also inequity in treatment-seeking for malaria and the poor spend proportionally more to treat the disease.</p> <p>Conclusion</p> <p>Inequities exist in how different SES groups perceive the levels of ease of accessibility and utilization of different providers for malaria treatment. The differentials in perceptions of ease of access and use as well as health seeking for different malaria treatment providers among SES groups could be decreased by reducing barriers such as the cost of treatment by making health services accessible, available and at reduced cost for all groups.</p

Socioeconomic dynamism and the growth of baby factories in Nigeria

Abstract: Illegally breeding babies for marketing purposes otherwise known as “infant commodification” is increasing in Nigeria. This menace is a vice that threatens the lives and wellbeing of babies, young girls, and women. This article investigates through an in-depth review of scholarly publication and media coverages the factors that have contributed to the emergence and growth of the illicit industry in Nigeria. It examines the role of cultural beliefs, social attitudes, and norms as well as the harsh economic conditions of the nation as factors playing pivotal roles in the continual growth of baby farming in Nigeria. Some of these sociocultural factors are social stigmatization of pregnancy outside wedlock, stigmatization of adopted children, and the importance attached to fertility and the demonization of childlessness. The article draws on Emile Durkheim anomie theory and Chambers dimensions of poverty to explain how breakdown within the nation’s socioeconomic structure has a concomitant impact in breading social vices. It concludes by recommending that there is a need to jettison stigmatizing sociocultural beliefs within the nation’s social fabrics. Responsive attitude toward family reproductive issues should be encouraged and finally the activities of health care providers, operators of nongovernmental organizations taking custody of babies and young girls be properly monitored. As well, stringent punishment be meted out to apprehended operators of these baby farms to serve as deterrent to others