12 research outputs found
ANTI-TRYPANOSOMAL POTENTIAL OF MOMORDICA BALSAMINA LINN FRUIT PULP EXTRACT AGAINST TRYPANOSOMA BRUCEI BRUCEI INFECTION
The search for new trypanocides has not been keenly pursued due to high cost of design and development with no promise of financial returns. Momordica balsamina fruit pulp extract was screened for antitrypanosomal activity in experimental T. brucei brucei infection in rabbits. The extract was administered prior to parasite inoculation, 24 hours post parasite inoculation and on establishment of infection. The treatment was by oral administration of the extract at 500mg/kg body weight for 14 consecutive days. Parasitaemia was monitored daily while body weight and packed cell volume (PCV) were determined before commencement of studies and subsequently at weekly intervals for 28 days. The result showed a significant (
Nkolbisine, a New Furoquinoline Alkaloid, and 7-Deacetylazadirone From Teclea verdoorniana
Use of 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole for Determining Cysteine and Cystine in Cereal and Legume Seeds
The structure of euphorianin, an ingol diterpenoid from <i>Euphorbia poisonii</i>
The residual uncertainty in the structure of euphorianin, an ingol diterpenoid from the latex of Euphorbia poisonii, has been resolved by nuclear Overhauser enhancement difference experiments which revealed the configuration at C-19 to be S. The 1H and 13C NMR spectroscopic properties of euphorianin and its transformation products are described
Chemical composition and antimicrobial activity of the seed oil of Entandrophragma angolense (Welw) C.DC
The seed of Entandrophragma angolense yielded 59% oil (w/w) on extraction with n-hexane. Methylation and gas chromatography-mass spectrometry (GC-MS) analysis of the methylated seed oil of E. angolense gave 11-octadecanoic acid methyl ester as major component (43.2%). Other fatty acid methyl esters (FAMEs) detected were hexadecanoic acid methyl ester, ricinoleic acid methyl ester, stearic acid methyl ester and eicosadienoic acid methyl ester. Preliminary antimicrobial evaluation of this seed oil showed activity against Salmonella gallinallum and Klebseilla pneumonia
Tetranortriterpenoids and related compounds. Part 26. Tecleanin, a possible precursor of limonin, and other new tetranortriterpenoids from <i>Teclea grandifolia</i> Engl. (Rutaceae)
Tecleanin and 7-deacetylproceranone, two new tetranortriterpenoids from Teclea grandifolia Engl. (Rutaceae), have been assigned structures (2) and (4) respectively. Tecleanin has the same highly oxidised ring A as limonin but a carbocyclic ring D. A third new limonoid was identified as 7-deacetylazadirone (13)
ANTIFUNGAL PRINCIPLE FROM THE STEM BARK OF BERLINA GRANDIFLORA
Lup-20(29)-en-3b-ol [lupeol] was isolated from the hexane fraction of the stem bark of Berlina grandiflora. The compound showed significant antifungal activity against Cladosporium cucumerinium.
Key Words: Berlina grandiflora, antifungal activity, lupeol and Cladosporium cucumerinium
[Nig. J. Nat. Prod. and Med. Vol.6 2002: 48-49
Chemical constituents and antimycobacterial studies of the leaf extracts of Pavetta crassipes K. Schum
Six known compounds; β-sitosterol, ursolic acid, methyl chlorogenate, ethyl chlorogenate, rutin and mannitol were isolated from the leaf extracts of Pavetta crassipes (Rubiaceae), a Nigerian medicinal plant used in the indigenous treatment of tuberculosis. Separation and isolation of the compounds were achieved by chromatographic techniques and the structures of isolated compounds were established by spectroscopic and chemical methods. The isolated compounds were screened for antimycobacterial activities against Mycobacterium tuberculosis H37Rv employing the green fluorescence protein reporter microplate assay and the broth microdilution method. Ursolic acid, methyl chlorogenate and ethyl chlorogenate were found moderately active in the broth microdilution assay with MICs of 200, 100 and 50 µg/ml, respectively while methyl chlorogenate and ethyl chlorogenate were active in the protein reporter microplate assay with MICs of 200 and 100 µg ml-1, respectively. The presence of antimycobacterial terpenoids and quinate esters in leaves of Pavetta crassipes provides scientific evidence for the ethnomedicinal use of the plant as a traditional anti-tuberculosis remedy