Erratum for “Genotyping of vacA alleles of Helicobacter pylori strains recovered from some Iranian food items”

Erratum for “Genotyping of vacA alleles of Helicobacter pylori strains recovered from some Iranian food items”Fatemeh Ghorbani, Elham Gheisari and Farhad Safarpoor DehkordiGhorbani et al Trop J Pharm Res 2016, 15(8): 1631-1636http://dx.doi.org/10.4314/tjpr.v15i8.5The correct affiliation, email and telephone number of the corresponding author are those provided above

Knowledge, attitude and perception on PharmD program among penultimate and final-year undergraduate pharmacy students in a Nigerian university – An intervention study

Purpose: To carry out an interventional study on the knowledge, attitude and perception of penultimate and final year undergraduate pharmacy students of the University of Ibadan on Doctor of Pharmacy (PharmD) program. Methods: A cross-sectional study was carried out among penultimate and final-year undergraduate students of the Faculty of Pharmacy, University of Ibadan using semi-structured questionnaire. A seminar was organized for the intervention group. The data were summarized using descriptive and inferential statistics. Results: Pre-intervention PharmD knowledge assessment of majority, 63 (94.0 %) control group and 63 (87.5 %) intervention group participants was below average. Post-intervention, 38 (52.8 %) intervention group participants had satisfactory scores, while 54 (80.6 %) of control group had below average scores. Generally, the participants had good PharmD attitude and perception. There was a significant difference (p < 0.001) between pre- and post-intervention PharmD knowledge assessment among the intervention group. A significant difference (p < 0.001) was observed between the post-intervention PharmD knowledge of the control group and the intervention group. Conclusion: Baseline below average PharmD knowledge of study participants improved significantly in the intervention group post-intervention. Generally, the participants had a good attitude and perception towards the PharmD program. Keywords: PharmD, Pre-post intervention, Undergraduate pharmacy students, Knowledge, Attitude, Perception, University of Ibada

Plasmodium falciparum malaria resistance to chloroquine in five communities in Southern Nigeria

Chloroquine is still a first-line antimalarial drug in uncomplicated falciparum malaria. Increasing resistance to chloroquine has been reported in many parts of Nigeria. Clinical and parasitological responses and classes of resistance to chloroquine in falciparum malaria in five communities in Delta region, southern Nigeria were assessed. Chloroquine was administered to 218 patients with uncomplicated P. falciparum malaria. The levels of parasitemia, clinical response and classes of resistance were monitored for 7 days. High levels of therapeutic failures of chloroquine in P. falciparum malaria were recorded in the region. The frequencies of clinical and parasitological failure of chloroquine were 25.7% and 55%, respectively. These frequencies were significantly lower in children below 5 years than older people. R2 and R3 resistance occurred in 37.2% and 17.4% of the patients, respectively. The therapeutic failure of chloroquine was not gender dependent. We conclude that chloroquine is still effective in the treatment of uncomplicated P. falciparum malaria in some communities in Delta region of Nigeria. However, resistance to chloroquine is likely. These results may be used as an important indicator of the significant level of therapeutic failure of uncomplicated P. falciparum malaria to chloroquine in Nigeria. Keywords: Chloroquine, falciparum malaria, resistance, clinical failure, parasitological failure. African Journal of Biotechnology Vol.2(10) 2003: 384-38

Prescribing practices in two health care facilities in Warri, Southern Nigeria: A comparative study

Purpose: Inappropriate prescribing has been identified in many health facilities in developing countries. The purpose of this study was to evaluate the prescribing practices in two health care facilities in Warri located in south-south geopolitical region of Nigeria and identify factors influencing the practices. Method: WHO Prescribing Indicators were applied to evaluate 2000 prescription records, retrospectively, from a private and a public hospital in Warri. Factors influencing the prescribing practices in the facilities were identified through informal interviews of 10 prescribers in the facilities. Using a self-administered questionnaire administered to 40 prescribers in the facilities, we also evaluated the order of importance of the factors affecting drug prescribing. Results: Average number of drugs per encounter in the health facilities is 3.4 (3.9 in the public hospital and 2.8 in the private hospital). Generic prescribing was generally low (54% in the public hospital and 16% in the private hospital) while the percentage of encounters with antibiotics prescribed was high (75% in the public hospital and 55% in the private hospital). Antimalarials, antihypertensives, antidiarrhoeals and analgesics accounted for 47.4%, 7.5%, 1.0% and 18.2%, respectively. The overuse of drugs and generic prescribing were significantly lower in the private hospital than in the public hospital. Major factors influencing prescribing practices included drug availability, clinician\'s level of training, cost of drugs, feedback from patients and socio-economic status of patients. Conclusion: Polypharmacy, overuse of antibiotics and low rate generic prescribing still occur in the health facilities studied. Drug availability, clinician\'s level of training, cost of drugs, feedback from patients and socio-economic status of patients are major factors influencing prescribing in the facilities. Keywords: Drug prescribing, Indicators, Practices, Southern Nigeria Tropical Journal of Pharmaceutical Research 2003; 2(1): 175-18

Response of Tripanosoma brucei brucei–induced anaemia to a commercial herbal preparation

Jubi Formula® is a herbal preparation made from three medicinal herbs (Parquetina nigrescens, Sorghum bicolor and Harungana madagascariensis). It has been reported to have been successfully used in the treatment of anaemia in humans. A study was therefore carried out to determine the effect of the preparation on packed cell volume (PCV) and haemoglobin (Hb) concentrations in anaemic rabbits. The PCV and Hb concentrations of healthy rabbits infected with Trypanosoma brucei brucei were monitored for 49 days. T. b. brucei produced a significant reduction in PCV and Hb concentrations in all infected rabbits when compared with the controls (

An overview of site-specific delivery of orally administered proteins/peptides and modelling considerations

Oral delivery of proteins and peptides poses one of the greatest challenges in controlled drug delivery due to degradation by proteolytic enzymes, poor membrane permeability and large molecular size. Therapeutic proteins/peptides are useful in correcting metabolic disorders (e.g., insulin in diabetes mellitus), as antineoplastic agents (e.g., cyclosporin A) and in hormone therapy (e.g., leutinizing hormone releasing hormone analogs in endometriosis and uterine fibroids). Thus, the importance of determining absorption efficiency of peptide and protein drugs is an important consideration. In oral peptide administration, the ideal delivery system is one that releases its contents only at the target region of the gastrointestinal tract (GIT) independent of patient variables while retaining the protein/peptide drug and their absorption promoters at the site of optimal absorption long enough to ultimately achieve maximum therapeutic benefit and safety. Various systems for achieving site-specific delivery of orally administered protein/peptide drugs have been developed in recent years including those based on pH changes, enzymatic activity of intestinal microflora, etc. This article discusses some of these systems including their relative merits and drawbacks. Some relevant mathematical models to resolve release patterns are also considered

Physicotechnical, spectroscopic and thermogravimetric properties of powdered cellulose and microcrystalline cellulose derived from groundnut shells

α-Cellulose and microcrystalline cellulose powders, derived from agricultural waste products, that have for the pharmaceutical industry, desirable physical (flow) properties were investigated. α–Cellulose (GCN) was extracted from groundnut shell (an agricultural waste product) using a non-dissolving method based on inorganic reagents. Modification of this α -cellulose was carried out by partially hydrolysing it with 2N hydrochloric acid under reflux to obtain microcrystalline cellulose (MCGN). The physical, spectroscopic and thermal properties of the derived α-cellulose and microcrystalline cellulose powders were compared with Avicel® PH 101, a commercial brand of microcrystalline cellulose (MCCA), using standard methods. X-ray diffraction and infrared spectroscopy analysis showed that the α-cellulose had lower crystallinity. This suggested that treatment with 2N hydrochloric acid led to an increase in the crystallinity index. Thermogravimetric analysis showed quite similar thermal behavior for all cellulose samples, although the α- cellulose had a somewhat lower stability. A comparison of the physical properties between the microcrystalline celluloses and the α-cellulose suggests that microcrystalline cellulose (MCGN and MCCA) might have better flow properties. In almost all cases, MCGN and MCCA had similar characteristics. Since groundnut shells are agricultural waste products, its utilization as a source of microcrystalline cellulose might be a good low-cost alternative to the more expensive commercial brand

Microencapsulated Garcinia kola and Hunteria umbellata Seeds Aqueous Extracts – Part 1: Effect of microencapsulation process.

Objective: This study investigates microcapsulated aqueous extracts of Garcinia kola (GK) and Hunteria umbellata (HU) seeds. Method: Extracts obtained after maceration of dried powdered seeds were prepared as microcapsules with chitosan-alginate by counterion coacervation method. Microcapsules were characterized using differential scanning calorimetry (DSC), x-ray diffractometry (XRD) and fourier transform infrared (FTIR) spectroscopy. In vitro release studies were carried out at pH 1.2 for 2 h and 6.8 for a further 10 h. Results: Between 20 and 50% extract release occurred from microcapsules after 2 h while conventional tablets released 100% after 1 h at simulated gastric pH. At pH 6.8, >80% of extract was released from microcapsules after 6 h. DSC revealed the presence of complex materials. XRD and FTIR showed stable character of the plant extracts within the microcapsules. Conclusion: Controlled release of aqueous extracts derived from these plants was achieved by microencapsulation and therefore can be developed as suitable delivery devices

Editorial

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