Weight changes induced by ingestion of Alomo bitters (A combination of herbal constituents): Experimental study on wistar rats

This study investigates Weight changes induced by ingestion of Alomo bitters (A combination of herbal constituents): Experimental study on  Wistar rats. The sixteen Wistar rats (151.67 ± 2.89 grams) involved in thestudy were divided into four groups; a control (Group A) and three test groups (B, C and D). For 3 weeks, group A (control) received normal feed (growers mash) with distilled water only, while groups B-D (test) received normal feed with water mixed with graded quantities of Alomo Bitters: B (7.5ml/kg), C (15ml/kg) and D (22.5ml/kg). Comparatively, the results showed that body weight gain was highest in the test groups (B-D) in a dosage duration fashion and lowest in the control group (22.40 ± 11.21g). Also, a non-significant variation in organ-weight was observed for the testis. The observed changes on body weight and weights of the liver, kidney and testis were dosage and duration dependent. Thus, alomo bitters may be important in weight and appetite management considering its effect on body weight. However, further investigations are required in this regard.Keywords: Mondia whitei, Herbs, Weight, Obesity, Appetite, Public Health issues

Nanomaterial-Enhanced Receptor Technology for Silicon On-Chip Biosensing Application

Nanomaterials integration in biosensors designs are known to enhance sensing and signaling capabilities by exhibiting remarkably high surface area enhancement and intrinsic reactivity owing to their distinctive optical, chemical, electrical and catalytic properties. We present the synthesis and characterization of silver nanoparticles (AgNPs), and their immobilization on a silicon on-chip biosensor platform to enhance sensing capability for prostate specific antigen (PSA) - cancer biomarkers. Several techniques, including UV-Visible (UV-Vis) absorption spectrum, Fourier transforms infrared spectroscopy (FTIR), high resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM) and field emission scanning electron microscopy (FESEM) were used for characterizing the AgNPs. The biochemical sensor consists of AgNPs immobilized on the receptor layer of a silicon avalanche mode light emitting device (Si AM LED) which enables on-chip optical detection biological analytes. A bio-interaction layer etched from the chip interacts with the evanescent field of a micro dimensioned waveguide. An array of detectors below the receptor cavity selectively monitor reflected light in the UV, visible, infrared and far infrared wavelength regions. AgNPs used as an immobilization layer in the receptor layer enhances selective absorption analytes, causing a change in detection signal as a function of propagation wavelength as light is dispersed. The analytes could range from gases to cancer biomarkers like prostate specific antigen

Применение эффекту Кирлиан для оценки структурообразования в водных системах

Технічно реалізовано два підходи до реєстрації ефекту Кірліан у рідинах. Проаналізовано три методи формування краплі рідини. На прикладі інформаційно-структурованих вод – «Моршинської» та «Даяни» – продемонстровані можливості розробленої апаратури. Показано, що в якості статистично достовірного структуризатора рідин може бути використаний магнітний прилад – Коректор функціонального стану (КФС).Two technical approaches were used two methods of register Kirlian effect in liquids. Three methods of liquid drop formation have been analyzed. Using informationally structured waters “Morshinskaya” and “Dayana” as the example. It was shown that magnet device, Corrector of functional state, can be used as statistically valid structurizer of liquids.Технически реализовано два подхода к регистрации эффекта Кирлиан в жидкостях Проанализировано три метода формирования капли жидкости. На примере информационно структурированных вод «Моршинской» и «Даяны» – продемонстрированы возможности разработанной аппаратуры. Показано, что в качестве статистически достоверного структуризатора жидкости можно использовать магнитный прибор – Корректор функционального состояния (КФС)

Система обеспечения подачи рапы необходимой концентрации для бальнеологических больниц

Розроблена система контролю та регулювання подачі водного розчину ропи складається з блоку фільтрації, двох контактних платино-платинованих двохелектродних датчиків виміру електропровідності, моста змінного струму та виконавчого механізму подачі ропи в накопичувальну ємність. Вибір метода контролю концентрації розчину обумовлено походженням зразків ропи з різних природних джерел.The developed control system for regulated supply of concentrated salt water solution (brine) consists of a filter block, two contact platinum-platinated 2-electrode sensors for measuring electroconductivity, alternating current bridge and working device of the brine delivery to an accumulating container. The above- mentioned way of the salt solution concentration control is determined by the brine sample origin from different mineral sources.Разработанная система контроля и регулирования подачи водного раствора рапы состоит из блока фильтрации, двух контактных платино-платинированых двухэлектродных датчиков измерения электропроводности, моста переменного тока и исполнительного механизма подачи рапы в накопительную емкость. Выбор метода контроля концентрации раствора обусловлено происхождением образцов рапы из разных природных источников

HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy:a collaborative cohort analysis

BACKGROUND The widespread use of the integrase strand transfer inhibitor (INSTI) dolutegravir in first-line and second-line antiretroviral therapy (ART) might facilitate emerging resistance. The DTG RESIST study combined data from HIV cohorts to examine patterns of drug resistance mutations (DRMs) and identify risk factors for dolutegravir resistance. METHODS We included cohorts with INSTI resistance data from two collaborations (ART Cohort Collaboration, International epidemiology Databases to Evaluate AIDS in Southern Africa), and the UK Collaborative HIV Cohort. Eight cohorts from Canada, France, Germany, Italy, the Netherlands, Switzerland, South Africa, and the UK contributed data on individuals who were viraemic on dolutegravir-based ART and underwent genotypic resistance testing. Individuals with unknown dolutegravir initiation date were excluded. Resistance levels were categorised using the Stanford algorithm. We identified risk factors for resistance using mixed-effects ordinal logistic regression models. FINDINGS We included 599 people with genotypic resistance testing on dolutegravir-based ART between May 22, 2013, and Dec 20, 2021. Most had HIV-1 subtype B (n=351, 59%), a third had been exposed to first-generation INSTIs (n=193, 32%), 70 (12%) were on dolutegravir dual therapy, and 18 (3%) were on dolutegravir monotherapy. INSTI DRMs were detected in 86 (14%) individuals; 20 (3%) had more than one mutation. Most (n=563, 94%) were susceptible to dolutegravir, seven (1%) had potential low, six (1%) low, 17 (3%) intermediate, and six (1%) high-level dolutegravir resistance. The risk of dolutegravir resistance was higher on dolutegravir monotherapy (adjusted odds ratio [aOR] 34·1, 95% CI 9·93-117) and dolutegravir plus lamivudine dual therapy (aOR 9·21, 2·20-38·6) compared with combination ART, and in the presence of potential low or low (aOR 5·23, 1·32-20·7) or intermediate or high-level (aOR 13·4, 4·55-39·7) nucleoside reverse transcriptase inhibitor (NRTI) resistance. INTERPRETATION Among people with viraemia on dolutegravir-based ART, INSTI DRMs and dolutegravir resistance were rare. NRTI resistance substantially increased the risk of dolutegravir resistance, which is of concern, notably in resource-limited settings. Monitoring is important to prevent resistance at the individual and population level and ensure the long-term sustainability of ART. FUNDING US National Institutes of Health, Swiss National Science Foundation

Pattern of certain anthropometric parameters of apparently healthy young adult Nigerians: implications for cardiovascular diseases and assessment of obesity

No Abstract. Journal of Experimental and Clinical Anatomy Vol. 5(1) 2006: 29-3