Compatibility between Independent Activities in the Course of Study for Schools for Special Needs Education and ICF Categories

In the 2009 amendment to the course of study for schools for special needs education, the new teaching guideline "independent activities" was introduced to teach skills that ease difficulties in learning and daily living. The present study aimed to clarify compatibility between the independent activities and ICF categories by conducting a survey of teaching staff in schools for special needs education. The independent activities consist of 6 major items accompanied by a total of 26 sub-items. The ICF involves 4 components: body functions and structures, activities and participation, environmental factors and personal factors. Thirty items at the first level of classification were employed for the present investigation, excluding personal factors. The independent activities were linked not only to activities and participation in the ICF, but also body functions and structures and environmental factors. Amongst the independent activities "psychological stability" had the largest degree of compatibility with ICF items (15 items); while "health care" and "understanding situations" had the smallest number (6 items). The results suggest that a combined use of independent activities and ICF categories provides a more useful and quantitative foundation to assess the independent activities and to facilitate individual teaching plans

Error Analysis of Overpassivized Sentences Written by Japanese High School Students : An English Essay Corpus

A prevalent error among English as a second language (ESL) writers of various native language groups is the overuse of passive sentences (overpassivization) when writing in English. Oshita (2001) proposed the unaccusative trap hypothesis, which posits that intermediate learners tend to overpassivize unaccusative (rather than unergative) verbs, and that novice learners are less prone to making these errors. The present study tested this hypothesis by analyzing written compositions from a group of 208 Japanese high school students who were considered at the early learning stage. The study also analyzed the effect of subject animacy on overpassivization, a point rather neglected by prior studies. Ten alternating unaccusative verbs, 15 non-alternating unaccusative verbs, and 15 unergative verbs were extracted from an approximately 60,000-word corpus of English compositions written by the participants. The results of this study did not support the unaccusative trap hypothesis, as they showed a relatively higher rate of overpassivized unergatives, compared with unaccusatives. It also showed that learners produced relatively more overpassivized unaccusatives with animate (rather than inanimate) objects, which contradicts the findings of previous studies. The resulting discussion centers around the possibility of Japanese learners’ equating English copula with Japanese topic markers, and directly translating Japanese causative-passives into overpassivized unergatives in English

Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone

BACKGROUND: Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive osteoclast precursor cells (OPCs) and osteoclasts (OCs), respectively. In this study, we investigated the pathogenesis of osteoclastic bone destruction in GCTs by focusing on the role of the vascular endothelial growth factor (VEGF)-Flt-1 (type-1 VEGF receptor)-focal adhesion kinase (FAK) pathway. METHODS: The motility of OPCs cells was assessed by a chemotaxis assay and the growth of OPCs was examined using a cell proliferation assay. The expression of VEGF and activation of Flt-1 and FAK in clinical GCT samples and in OPCs were detected by immunohistochemistry and immunoblotting. The correlation between the expression levels of activated Flt-1 and FAK and clinical stages of GCTs was investigated by immunohistochemistry. RESULTS: In GCT samples, CD68, a marker of OPCs and OCs, co-localized with Flt-1. Conditioned media from GCT tissue (GCT-CM) enhanced the chemotaxis and proliferation of OPCs. GCT-CM also stimulated FAK activation in OPCs in vitro. Moreover, there was a correlation between the clinical stage of GCTs and the expression of tyrosine-phosphorylated Flt-1 and FAK. CONCLUSIONS: Our results suggest that the VEGF-Flt-1-FAK pathway is involved in the pathogenesis of bone destruction of GCTs

Scenery from the Top: Study of the Third Generation Squarks at CERN LHC

In the minimal supersymmetric standard model (MSSM) properties of the third generation sfermions are important from the viewpoint of discriminating the SUSY breaking models and in the determination of the Higgs boson mass. If gluinos are copiously produced at CERN LHC, gluino decays into tb through stop and sbottom can be studied using hadronic decays of the top quark. The kinematical endpoint of the gluino decays can be evaluated using a W sideband method to estimate combinatorial backgrounds. This implies that fundamental parameters related to the third generation squarks can be reliably measured. The top-quark polarization dependence in the decay process may also be extracted by looking at the b jet distribution near the kinematical endpoint.Comment: 4 pages in PRL format, 4 Postscript figures, uses revtex

A Detailed Study of the Gluino Decay into the Third Generation Squarks at the CERN LHC

In supersymmetric models a gluino can decay into tb\tilde{\chi}^{\pm}_1 through a stop or a sbottom. The decay chain produces an edge structure in the m_{tb} distribution. Monte Carlo simulation studies show that the end point and the edge height would be measured at the CERN LHC by using a sideband subtraction technique. The stop and sbottom masses as well as their decay branching ratios are constrained by the measurement. We study interpretations of the measurement in the minimal supergravity model. We also study the gluino decay into tb and \tilde{\chi}^{\pm}_2 as well as the influence of the stop left-right mixing on the m_{bb} distribution of the tagged $tb$ events.Comment: revtex, 20 pages in PRD format, 35 eps file

J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan

The Japan Chronic Kidney Disease (CKD) Database (J-CKD-DB) is a large-scale, nation-wide registry based on electronic health record (EHR) data from participating university hospitals. Using a standardized exchangeable information storage, the J-CKD-DB succeeded to efficiently collect clinical data of CKD patients across hospitals despite their different EHR systems. CKD was defined as dipstick proteinuria ≥1+ and/or estimated glomerular filtration rate <60 mL/min/1.73 m² base on both out- and inpatient laboratory data. As an initial analysis, we analyzed 39, 121 CKD outpatients (median age was 71 years, 54.7% were men, median eGFR was 51.3 mL/min/1.73 m²) and observed that the number of patients with a CKD stage G1, G2, G3a, G3b, G4 and G5 were 1, 001 (2.6%), 2, 612 (6.7%), 23, 333 (59.6%), 8, 357 (21.4%), 2, 710 (6.9%) and 1, 108 (2.8%), respectively. According to the KDIGO risk classification, there were 30.1% and 25.5% of male and female patients with CKD at very high-risk, respectively. As the information from every clinical encounter from those participating hospitals will be continuously updated with an anonymized patient ID, the J-CKD-DB will be a dynamic registry of Japanese CKD patients by expanding and linking with other existing databases and a platform for a number of cross-sectional and prospective analyses to answer important clinical questions in CKD care

Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

Background: The Japan Chronic Kidney Disease Database (J-CKD-DB) is a nationwide clinical database of patients with chronic kidney disease (CKD) based on electronic health records. The objective of this study was to assess the prevalence of anemia and the utilization rate of erythropoiesis-stimulating agents (ESAs) in Japanese patients with CKD. Methods: In total, 31, 082 adult outpatients with estimated glomerular filtration rates of 5–60 ml/min/1.73 m2 in seven university hospitals were included this analysis. The proportions of patients with CKD stages G3b, G4, and G5 were 23.5%, 7.6%, and 3.1%, respectively. Results: The mean (standard deviation) hemoglobin level of male patients was 13.6 (1.9) g/dl, which was significantly higher than the mean hemoglobin level of female patients (12.4 (1.6) g/dl). The mean (standard deviation) hemoglobin levels were 11.4 (2.1) g/dl in patients with CKD stage G4 and 11.2 (1.8) g/dl in patients with CKD stage G5. The prevalences of anemia were 40.1% in patients with CKD stage G4 and 60.3% in patients with CKD stage G5. Logistic regression analysis showed that diagnoses of CKD stage G3b (adjusted odds ratio [95% confidence interval]: 2.32 [2.09–2.58]), G4 (5.50 [4.80–6.31]), and G5 (9.75 [8.13–11.7]) were associated with increased prevalence of anemia. The utilization rates of ESAs were 7.9% in patients with CKD stage G4 and 22.4% in patients with CKD stage G5. Conclusions: We determined the prevalence of anemia and utilization rate of ESAs in Japanese patients with CKD using data from a nationwide cohort study

Supercollider Signatures of Supergravity Models with Yukawa Unification

We study the predictions of the simplest SU(5) grand unified model within the framework of minimal supergravity, including constraints from the radiative breaking of electroweak symmetry. As a consequence of the unification of the $b$-quark and $\tau$-lepton Yukawa couplings, the top quark mass is predicted to be close to its fixed point value. We delineate the regions of the supergravity parameter space allowed by constraints from the non-observation of proton decay and from the requirement that the LSP does not overclose the universe. These constraints lead to a definite pattern of sparticle masses: the feature unique to Yukawa unified models is that some of the third generation squarks are much lighter than those of the first two generations. Despite the fact that all sparticle masses and mixings are determined by just four SUSY parameters at the GUT scale (in addition to $m_t$), we find that the signals for sparticle production can vary substantially over the allowed parameter space. We identify six representative scenarios and study the signals from sparticle production at the LHC. We find that by studying the signal in various channels, these scenarios may be distinguished from one another, and also from usually studied ``minimal models'' where squarks and sleptons are taken to be degenerate. In particular, our studies allow us to infer that some third generation squarks are lighter than other squarks---a feature that could provide the first direct evidence of supergravity grand unification.Comment: 28 pages Revtex files with 5 PS figures available from [email protected], Preprint nos. FSU-HEP-940311, KEK-TH-392, MAD/PH/825, UH-511-785-9

The fate of the B ball

The gauge-mediated SUSY-breaking (GMSB) model needs entropy production at a relatively low temperature in the thermal history of the Universe for the unwanted relics to be diluted. This requires a mechanism for the baryogenesis after the entropy production, and the Affleck and Dine (AD) mechanism is a promising candidate for it. The AD baryogenesis in the GMSB model predicts the existence of the baryonic Q ball, that is the B ball, and this may work as the dark matter in the Universe. In this article, we discuss the stability of the B ball in th presence of baryon-number violating interactions. We find that the evaporation rate increases monotonically with the B-ball charge because the large field value inside the B ball enhances the effect of the baryon-number-violating operators. While there are some difficulties to evaluate the evaporation rate of the B ball, we derive the evaporation time (lifetime) of the B ball for the mass-to-charge ratio \omega_0\gsim 100 \MEV. The lifetime of the B ball and the distortion of the cosmic ray positron flux and the cosmic background radiation from the B ball evaporation give constraints on the baryon number of the B ball and the interaction, if the B ball is the dark matter. We also discuss some unresolved properties of the B ball.Comment: 27 pages incl 8 figs, LaTe