On the excitation and inhibition of the inspiratory neuron in the respiratory centers

In decerebrated cats the impulse discharges were detected by means of an unipolar microelectrode from a single inspiratory neuron in the respiratory centers, and the change in discharge produced by administration of stimulating, as well as depressant agents, was studied. The results were summarized as follows. 1) Inhalation of the air containing all. excess of carbon dioxide, as well as the air deficient of oxygen and the intravenous administration of a small dose of caffeine, aminocordine and lobeline produced a) a remarkable increase of frequency of impulses in the stage of constant frequency of the volley, b) a rapid increase of frequency of impulses in the stage of crescent frequency of the volley and c) a shortening of the duration of the volleys, as well as of silent periods. 2) In narcosis by a moderate dose of morphine, as well as in the recovery stage from apnea produced by over-ventilation, there were observed the phenomena which were exactly opposite to those described in 1). 3) It was concluded that a most essential sign by which one can discern whether the activity of the respiratory Genters is raised or depressed, is the changes of the frequency of impulses produced from an inspiratory neuron. The expense of this research was defrayed from the grant in aid of the Ministry of Education.</p

The action of atropine and acetylcholine on the pace maker ganglion cells of limulus heart

On the median nerve trunk-heart muscle preparation of Limulus the authors studied the effects of atropine and acetylcholine upon the pace maker ganglion cells. The results are summarized as follows: (1) Atropine exerts an excitatory action on the pace maker ganglion cells in a concentration of 1-2 per cent. resulting in an increase of the heart rate. No effect is recognized on the heart beats, where the drug is applied to the heart muscle. (2) Acetylcholine exerts an excitatory action in a lower concentration (0.001-0.10 %) and produces a transitory excitation followed by an inhibition in a higher concentration (1-5 %). No effect is perceptible on the heart beats, when the drug is applied to the heart muscle. (3) Where atropine has been previously applied to the median nerve trunk, acetylcholine applied to the same spot produces always an inhibition of the heart beats. Conversely, when the ganglion cells activated previously by acetylcholine, a subsequent administration of atropine suppresses the activity of the ganglion cells, resulting in an inhibition of the heart beats.</p

On the Behavior of the Respiratory Muscles During Vomiting

In order to produce vomiting in the dogs decerebrated and unanesthetized, apomorphine or copper sulfate was administered. The behaviors of both the inspiratory and the expiratory muscles were studied through the course of the act of vomiting by the electromyographic technique. The results are summarized as follows: (1) The most significant signs of vomiting seems to be the recurrent vomiting volleys from the vomiting center each of which is produced abruptly and transiently. (2) The peculiarities of the vomitng volley consist in the simultaneous discharges of both the inspiratory and the expiratory muscles, resulting in the so-called retching movement. (3) The vomiting volleys, in their rhythm, seem to arise independent of the respiratory center, but the former are capable of affecting the respiratory centers at any respiratory phase. (4) The acceleration of the breathings observed prior to the retching seems to be due to the invigorated activity of the respiratory centers affected directly by the administration of the vomiting agents without an intermediate step by the vomiting centers. (5) The simultaneous contraction of the diaphragm and the abdominal muscles are merely a component of a peculiar type of the respiratory movements, namely, that of the retching. (6) The glottis muscles are, however, ruled out from the principle described in (2): the closer of the glottis muscles contracts during the retching, while the opener is completely inhibited.</p

A Factor Condition­ing the Inhibitory Response of the Intestinal Motility to the Peripheral Stimulation of the Cervical Vagus Nerves

Recording the motility of the stomach as well as the small intestine by the balloon method in the dogs decerebrated and unanesthetized, we found a factor conditioning the inhibitory effect of the intestinal motility to the stimulation of the perpheral cut-end of cervical vagus nerves. The results may be summarized as follows: (1) The stimulation of the peripheral cut-end of the cervical vagus nerve frequently produces the yarious patterns and degrees of inhibition of the intestinal motility of the stomach as well as of the small intestine. (2) The inhibitory effect still appears after the severing of the vagus nerves at the caudal end of the esophagus, but is obliterated and reversed to the augmentory when the splanchnic nerves are bilaterally severed. (3) The cause of the inhibition is attributable to the strong excitation of the intestinal inhibitory centers brought about by the central stimulating action of the anoxemia resulting from the stimulation of the cervical vagus nerves, and the reversal of the response is due to the peripheral stimulating action of the anoxemia upon the intestinal muscles, its central action being excluded from the action on the intestine by the severing of the splanchnic nerves.</p

The asset-and-liability view and the income concepts in Japan / Hiromasa Okada

This paper clarifies the fundamental income computational structure under the Asset-and-Liability view. According to this income view, income is the increase/decrease in the net asset of an enterprise and key concepts are asset and liability. Thus, in the fundamental income computational structure, income is calculated in the balance sheet with the causes of income being explained in the income statement. However, the income statement does not necessarily have to explain all causes of income. In the clarification of the fundamental structure, this paper examines income concepts defined in the memorandum of the ASBJ (Accounting Standards Board of Japan) where comprehensive income and net income are defined. Comprehensive income is to be based on the Asset-and-Liability view, net income on the Revenue-and-Expense view. These two income concepts may lead to duality of periodical income allocation in Japan. This paper considers the reason for co-existence of two different types of income in terms of the fundamental income computational structure of the Asset-and-Liability view

Market Risk Disclosures: A Comparison between Companies in Japan and China

This paper presents a comparative analysis of market risk disclosure by Japanese and Chinese companies whose stocks are traded on New York Stock Exchange (NYSE) as American Depository Receipts (ADRs) as well as on stock exchange of their own home country. All the companies selected in this study made quantitative disclosures on Item 11 in their 20-F reports to the U.S. Securities and Exchange Commission (SEC)．However, in Japan, only two companies made quantitative disclosures outside the financial statements and none of them disclosed information specified for market risks in their notes to the financial statements in their annual securities reports. In China, only one company made quantitative disclosures outside the financial statements in their A-shares reports and the number of companies making quantitative disclosures in the notes to the financial statements in the 20-F reports exceeded those in their Ashare reports. It appears that the Japanese companies disclose information specifically required by the SEC but not disclosing them anywhere else. It also appears that the Chinese companies don\u27t disclose identical information in the U.S. and China although the financial statements reported in the U.S. used International Financial Reporting Standards (IFRS) and Hong Kong financial reporting standards and those reported in China used China\u27s accounting standards which are similar to IFRS

Effects of Vesical Distention on Parasympathetic Outflow to the Colon of Dogs

The vesico-colonic reflex transmitted via the pelvic nerve was studied in dogs and it was found that the reflex consists of four elemental components. 1. Vesical distention produced an inhibition of rectal parasympathetic outflow without eliciting any vesical parasympathetic outflow in decerebrated and spinal dogs. 2. An afterdischarge usually followed the inhibition. These results show that the sacral defecation reflex center is inhibited by vesical afferents, and produces a rebound excitation eliciting the afterdischarge. 3. An inhibition of the rectal outflow occurred simultaneously with waxing of the vesical outflow during constant afferent stimulation of the vesical and rectal branches of the pelvic nerve in dogs from which the colon and urinary bladder had been removed. This inhibition may be produced by an efference copy from the pontine micturition reflex center. Most recto-colonic branches of the nerve responded to vesical distention with these inhibitions and afterdischarge. Corresponding to these responses colonic motility was inhibited and/or enhanced. 4. Eleven of 26 recto-anal branches of the nerve responded to vesical distention with an enhanced outflow elicited simultaneously with an enhanced vesical outflow. This enhancement was abolished by transection of CI, which indicates that it may be caused by an efference copy from the pontine micturition reflex center

Microstructures and luminescent properties of Ce-doped transparent mica glass-ceramics

Transparent mica glass-ceramics were prepared by heating parent glasses that had been doped with 0.5-15 mol% CeO2. During the melting and heat treatment, Ce4+ ions in the specimens were reduced to Ce3+ ions, and one or both of these ion species were then replaced with Li+ ions in the interlayers of the separated mica crystals. However, scanning transmission electron microscope (STEM) and Z-contrast imaging revealed that the mica crystals did not contain the same amount of Ce. On excitation at 254 nm, the parent glasses and glass-ceramics emitted blue light, which originated from the 5d to 4f transition of the Ce3+ ions. The emission of the glass-ceramic containing a smaller amount of Ce was attributed to the Ce3+ ions in both the glass phase and the mica crystals, whereas that of the glass-ceramics containing a larger amount of Ce was caused mainly by Ce3+ ions in the mica crystals. The dependence of the emission band of the parent glasses on the amount of Ce was a unique feature of the Ce-doped transparent mica glass-ceramics and was not observed in previous studies of Eu-doped parent glasses and mica glass-ceramics.ArticleMATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS. 177(7):504-509 (2012)journal articl

Effects of Erbium-Doped: Yttrium Aluminum Garnet (Er: YAG) Laser on Bacteremia due to Scaling and Root Planing

INTRODUCTION: The aims of the present study were: [1] to evaluate whether Erbium-Doped: Yttrium, Aluminum and Garnet (Er: YAG) laser could be a prophylactic methods against transient bacteremia during scaling and root planing (SRP) [2] to confirm the efficacies of SRP with Er: YAG laser by clinical and microbiologic evaluations.METHODS: Twenty chronic periodontitis subjects were randomly treated for quadrant SRP with either conventional hand instrument (n=10) or Er: YAG laser (n=10) monotherapy. Peripheral blood samples were drawn at baseline and 6 minutes after initiation of SRP, and were cultured for the analysis of bacteremia. Clinical measurements of full mouth plaque control record (PCR), probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP) were made at baseline and 1 month after SRP. In addition, microbiologic analyses of subgingival samples were also performed at baseline and 1 month after SRP using the polymerase chain reaction Invader method.RESULTS: The incidence of bacteremia during SRP was 0% (0/10) in the Er: YAG laser group and 80% (8/10) in the hand instrument group, which was significantly different (P = 0.0003). All isolates from blood were facultative or obligate anaerobes and more than half of the microorganisms were species of streptococci. Intragroup comparison revealed that the mean PPD and CAL significantly decreased compared to baseline in both groups (P &lt; 0.05). However, the percentage of BOP positive significantly decreased only in Er: YAG laser group (P = 0.005). In addition, the reductions of the subgingival bacterial counts between baseline and 1 month after SRP were also comparable between the two groups.CONCLUSION: The present study demonstrated that SRP with Er: YAG laser could not only be an alternative treatment for improvement of clinical and microorganisms situations but also a novel prophylactic method against transient bacteremia

Three Type 6 Hepatitis C Virus Subgroups among Blood Donors in the Yangon Area of Myanmar Are Identified as Subtypes 6m and 6n, and a Novel Subtype by Sequence Analysis of the Core Region.

Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identifi ed as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The fi ndings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classifi cation