225 research outputs found
Magnetothermal Conductivity of Highly Oriented Pyrolytic Graphite in the Quantum Limit
We report on the magnetic field (0TT) dependence of the
longitudinal thermal conductivity of highly oriented pyrolytic
graphite in the temperature range 5 K 20 K for fields parallel to
the axis. We show that shows large oscillations in the
high-field region (B > 2 T) where clear signs of the Quantum-Hall effect are
observed in the Hall resistance. With the measured longitudinal electrical
resistivity we show that the Wiedemann-Franz law is violated in the high-field
regime.Comment: 4 Figures, to be published in Physical Review B (2003
Thermohydrodynamics in Quantum Hall Systems
A theory of thermohydrodynamics in two-dimensional electron systems in
quantizing magnetic fields is developed including a nonlinear transport regime.
Spatio-temporal variations of the electron temperature and the chemical
potential in the local equilibrium are described by the equations of
conservation with the number and thermal-energy flux densities. A model of
these flux densities due to hopping and drift processes is introduced for a
random potential varying slowly compared to both the magnetic length and the
phase coherence length. The flux measured in the standard transport experiment
is derived and is used to define a transport component of the flux density. The
equations of conservation can be written in terms of the transport component
only. As an illustration, the theory is applied to the Ettingshausen effect, in
which a one-dimensional spatial variation of the electron temperature is
produced perpendicular to the current.Comment: 10 pages, 1 figur
Thermoelectric Response of an Interacting Two-Dimensional Electron Gas in Quantizing Magnetic Field
We present a discussion of the linear thermoelectric response of an
interacting electron gas in a quantizing magnetic field. Boundary currents can
carry a significant fraction of the net current passing through the system. We
derive general expressions for the bulk and boundary components of the number
and energy currents. We show that the local current density may be described in
terms of ``transport'' and ``internal magnetization'' contributions. The latter
carry no net current and are not observable in standard transport experiments.
We show that although Onsager relations cannot be applied to the local current,
they are valid for the transport currents and hence for the currents observed
in standard transport experiments. We relate three of the four thermoelectric
response coefficients of a disorder-free interacting two-dimensional electron
gas to equilibrium thermodynamic quantities. In particular, we show that the
diffusion thermopower is proportional to the entropy per particle, and we
compare this result with recent experimental observations.Comment: 18 pages, 2 postscript figures included. Revtex with epsf.tex and
multicol.sty. In the revised version, the comparison with experimental
observations at is extended to include the possibility of
corrections due to weak impurity scattering. The conclusions that we reach
regarding the applicability of the composite fermion model at these filling
fractions are not affecte
The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells
Abstract
Introduction
There is growing evidence that the Wilms' tumor 1 suppressor gene (WT1) behaves as an oncogene in some forms of breast cancer. Previous studies have demonstrated that the N-terminal domain of WT1 can act as a dominant negative through self-association. In the studies presented here we have explored the potential for the zinc finger domain (ZF) of WT1 to also have dominant-negative effects, and thus further our understanding of this protein.
Methods
Using full-length and ZF-only forms of WT1 we assessed their effect on the WT1 and c-myc promoter using luciferase and chromatin immunoprecipitation assays. The gene expression levels were determined by quantitative real-time RT-PCR, northern blot and western blot. We also assessed the effect of the ZF-only form on the growth of breast cancer cell lines in culture.
Results
Transfection with WT1–ZF plasmids resulted in a stronger inhibition of WT1 promoter than full-length WT1 in breast cancer cells. The WT1–ZF form lacking the lysine–threonine–serine (KTS) insert (ZF - KTS) can bind to the majority of WT1 consensus sites throughout the WT1 promoter region, while the ZF containing the insert (ZF + KTS) form only binds to sites in the proximal promoter. The abundances of endogenous WT1 mRNA and protein were markedly decreased following the stable expression of ZF - KTS in breast cancer cells. The expressions of WT1 target genes, including c-myc, Bcl-2, amphiregulin and TERT, were similarly suppressed by ZF - KTS. Moreover, WT1–ZF - KTS abrogated the transcriptional activation of c-myc mediated by all four predominant isoforms of WT1 (including or lacking alternatively spliced exons 5 and 9). Finally, WT1–ZF - KTS inhibited colony formation and cell division, but induced apoptosis in MCF-7 cells.
Conclusion
Our observations strongly argue that the WT1–ZF plasmid behaves as a dominant-negative regulator of the endogenous WT1 in breast cancer cells. The inhibition on proliferation of breast cancer cells by WT1–ZF - KTS provides a potential candidate of gene therapy for breast cancer
Diffusion Thermopower at Even Denominator Fractions
We compute the electron diffusion thermopower at compressible Quantum Hall
states corresponding to even denominator fractions in the framework of the
composite fermion approach. It is shown that the deviation from the linear low
temperature behavior of the termopower is dominated by the logarithmic
temperature corrections to the conductivity and not to the thermoelectric
coefficient, although such terms are present in both quantities. The enhanced
magnitude of this effect compared to the zero field case may allow its
observation with the existing experimental techniques.Comment: Latex, 12 pages, Nordita repor
Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.
Fustin, J.-M., Kojima, R., Itoh, K., Chang, H.-Y., Shiqi, Y., Zhuang, B., . . . Okamura, H. (2018). Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. Proceedings of the National Academy of Sciences of the United States of America, 115(23), 5980-5985. doi:10.1073/pnas.172137111
Current-induced cooling phenomenon in a two-dimensional electron gas under a magnetic field
We investigate the spatial distribution of temperature induced by a dc
current in a two-dimensional electron gas (2DEG) subjected to a perpendicular
magnetic field. We numerically calculate the distributions of the electrostatic
potential phi and the temperature T in a 2DEG enclosed in a square area
surrounded by insulated-adiabatic (top and bottom) and isopotential-isothermal
(left and right) boundaries (with phi_{left} < phi_{right} and T_{left}
=T_{right}), using a pair of nonlinear Poisson equations (for phi and T) that
fully take into account thermoelectric and thermomagnetic phenomena, including
the Hall, Nernst, Ettingshausen, and Righi-Leduc effects. We find that, in the
vicinity of the left-bottom corner, the temperature becomes lower than the
fixed boundary temperature, contrary to the naive expectation that the
temperature is raised by the prevalent Joule heating effect. The cooling is
attributed to the Ettingshausen effect at the bottom adiabatic boundary, which
pumps up the heat away from the bottom boundary. In order to keep the adiabatic
condition, downward temperature gradient, hence the cooled area, is developed
near the boundary, with the resulting thermal diffusion compensating the upward
heat current due to the Ettingshausen effect.Comment: 25 pages, 7 figure
Quasiparticle Hall Transport of d-wave Superconductors in Vortex State
We present a theory of quasiparticle Hall transport in strongly type-II
superconductors within their vortex state. We establish the existence of
integer quantum spin Hall effect in clean unconventional
superconductors in the vortex state from a general analysis of the
Bogoliubov-de Gennes equation. The spin Hall conductivity is
shown to be quantized in units of . This result does not
rest on linearization of the BdG equations around Dirac nodes and therefore
includes inter-nodal physics in its entirety. In addition, this result holds
for a generic inversion-symmetric lattice of vortices as long as the magnetic
field satisfies . We then derive the
Wiedemann-Franz law for the spin and thermal Hall conductivity in the vortex
state. In the limit of , the thermal Hall conductivity satisfies
. The
transitions between different quantized values of as well as
relation to conventional superconductors are discussed.Comment: 18 pages REVTex, 3 figures, references adde
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