原発性尿管アミロイドージス - 症例報告 -

われわれは原発性尿管アミロロドージスの1症例を最近経験した。 症例は52歳女子で肉眼的血尿を主訴として当科外来を受診, IVPで右水腎症，膀胱鏡で右尿管口より乳頭状かつ浮腫の強い腫瘤を認めたので、生検をおこなった。初診よりI年後の再度の生検で尿管アミ戸イドージスの診断を得た。右水腎症が尤進し，聖事痛持続するため，右腎尿管全摘術を施行した.摘出標本の電顕像が得られたので，若干の文献的考察を加えて報告した。Primary localized amyloidosis of the urinary tract, especially that of the ureter, is rare. Nine cases of the ureteral amyloidosis have been reported In the world (Table) .1-9) We have recently experienced the case which was preoperatively diagnosed as right ureteral amyloidosis, and its electron micrograph was obtained

Rule-based Assembly for Short-read Datasets Obtained with Multiple Assemblers and k-mer Sizes

Various de novo assembly methods based on the concept of k-mer have been proposed. Despite the success of these methods, an alternative approach, referred to as the hybrid approach, has recently been proposed that combines different traditional methods to effectively exploit each of their properties in an integrated manner. However, the results obtained from the traditional methods used in the hybrid approach depend not only on the specific algorithm or heuristics but also on the selection of a user-specific k-mer size. Consequently, the results obtained with the hybrid approach also depend on these factors. Here, we designed a new assembly approach, referred to as the rule-based assembly. This approach follows a similar strategy to the hybrid approach, but employs specific rules learned from certain characteristics of draft contigs to remove any erroneous contigs and then merges them. To construct the most effective rules for this purpose, a learning method based on decision trees, i.e., a complex decision tree, is proposed. Comparative experiments were also conducted to validate the method. The results showed that proposed method could outperformed traditional methods in certain cases