Pathogenetic role and clinical implications of regulatory RNAs in biliary tract cancer

Biliary tract cancer (BTC) is characterised by poor prognosis and low overall survival in patients. This is generally due to minimal understanding of its pathogenesis, late diagnosis and limited therapeutics in preventing or treating BTC patients. Non-coding RNA (ncRNA) are small RNAs (mRNA) that are not translated to proteins. ncRNAs were considered to be of no importance in the genome, but recent studies have shown they play essential roles in biology and oncology such as transcriptional repression and degradation, thus regulating mRNA transcriptomes. This has led to investigations into the role of ncRNAs in the pathogenesis of BTC, and their clinical implications. In this review, the mechanisms of action of ncRNA are discussed and the role of microRNAs in BTC is summarised. The scope of this review will be limited to miRNA as they have been shown to play the most significant roles in BTC progression. There is huge potential in miRNA-based biomarkers and therapeutics in BTC, but more studies, research and technological advancements are required before it can be translated into clinical practice for patients

Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer

Biliary tract cancer (BTC) is characterised by poor prognosis and low overall survival in patients. This is generally due to minimal understanding of its pathogenesis, late diagnosis and limited therapeutics in preventing or treating BTC patients. Non-coding RNA (ncRNA) are small RNAs (mRNA) that are not translated to proteins. ncRNAs were considered to be of no importance in the genome, but recent studies have shown they play essential roles in biology and oncology such as transcriptional repression and degradation, thus regulating mRNA transcriptomes. This has led to investigations into the role of ncRNAs in the pathogenesis of BTC, and their clinical implications. In this review, the mechanisms of action of ncRNA are discussed and the role of microRNAs in BTC is summarised. The scope of this review will be limited to miRNA as they have been shown to play the most significant roles in BTC progression. There is huge potential in miRNA-based biomarkers and therapeutics in BTC, but more studies, research and technological advancements are required before it can be translated into clinical practice for patients

Analytical modeling of pipeline failure in multiphase flow due to corrosion in Niger Delta Region

Pipeline could be said to be the safest and the most economical means of transportation of hydrocarbon fluids. Pipelines carrying oil and gas may suffer from internal corrosion when water is present. The corrosivity varies due to several factors such as; temperature, total pressure, CO2 and H2S content in the gas, pH of the water, flow conditions, inhibiting chemicals etc. Corrosion, when not properly dealt with could lead to pipeline integrity issues which will be very uneconomical for the operator company. This research focuses on the development of a model that can predict pipeline failure due to corrosion in multiphase flows. The role that velocity, density, water cut and other parameters play in predicting corrosion is critically analyzed with Norsok Model. The result shows that velocity plays a key role in corrosion prediction.Increasing oil velocity from 0.1 to 1.25 m/s leads to an increase of corrosion rate from 1.67 to 5.58 mm/yr. This is because at the selected pH of 4, the corrosion rate is very sensitive to mass transfer and turbulent mixing which are in turn enhanced at higher flow rates