FLAGCAL:A flagging and calibration package for radio interferometric data

We describe a flagging and calibration pipeline intended for making quick look images from GMRT data. The package identifies and flags corrupted visibilities, computes calibration solutions and interpolates these onto the target source. These flagged calibrated visibilities can be directly imaged using any standard imaging package. The pipeline is written in "C" with the most compute intensive algorithms being parallelized using OpenMP.Comment: 15 Pages, 6 figures, 2 Tables, Accepted for publication in the Experimental Astronomy Journa

Extragalactic Radio Continuum Surveys and the Transformation of Radio Astronomy

Next-generation radio surveys are about to transform radio astronomy by discovering and studying tens of millions of previously unknown radio sources. These surveys will provide new insights to understand the evolution of galaxies, measuring the evolution of the cosmic star formation rate, and rivalling traditional techniques in the measurement of fundamental cosmological parameters. By observing a new volume of observational parameter space, they are also likely to discover unexpected new phenomena. This review traces the evolution of extragalactic radio continuum surveys from the earliest days of radio astronomy to the present, and identifies the challenges that must be overcome to achieve this transformational change.Comment: To be published in Nature Astronomy 18 Sept 201

The Murchison Widefield Array Transients Survey (MWATS). A search for low-frequency variability in a bright Southern hemisphere sample

We report on a search for low-frequency radio variability in 944 bright (>4 Jy at 154 MHz) unresolved, extragalactic radio sources monitored monthly for several years with the Murchison Widefield Array. In the majority of sources, we find very low levels of variability with typical modulation indices 2.8 yr) with time-averaged modulation indices M¯¯¯¯¯=3.1−7.1M¯=3.1−7.1 per cent. With 7/15 of these variable sources having peaked spectral energy distributions, and only 5.7 per cent of the overall sample having peaked spectra, we find an increase in the prevalence of variability in this spectral class. We conclude that the variability seen in this survey is most probably a consequence of refractive interstellar scintillation and that these objects must have the majority of their flux density contained within angular diameters less than 50 milliarcsec (which we support with multiwavelength data). At 154 MHz, we demonstrate that interstellar scintillation time-scales become long (∼decades) and have low modulation indices, while synchrotron-driven variability can only produce dynamic changes on time-scales of hundreds of years, with flux density changes less than one milli-jansky (without relativistic boosting). From this work, we infer that the low-frequency extragalactic southern sky, as seen by SKA-Low, will be non-variable on time-scales shorter than 1 yr

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

RNA crystallization and phasing represent major bottlenecks in RNA structure determination. Seeking to exploit antibody fragments as RNA crystallization chaperones, we have used an arginine-enriched synthetic Fab library displayed on phage to obtain Fabs against the class I ligase ribozyme. We solved the structure of a Fab–ligase complex at 3.1-Å resolution using molecular replacement with Fab coordinates, confirming the ribozyme architecture and revealing the chaperone's role in RNA recognition and crystal contacts. The epitope resides in the GAAACAC sequence that caps the P5 helix, and this sequence retains high-affinity Fab binding within the context of other structured RNAs. This portable epitope provides a new RNA crystallization chaperone system that easily can be screened in parallel to the U1A RNA-binding protein, with the advantages of a smaller loop and Fabs′ high molecular weight, large surface area and phasing power.National Institutes of Health (U.S.) (GM61835

Searching for dark matter signals from local dwarf spheroidal galaxies at low radio frequencies in the GLEAM survey

© 2020 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society The search for emission from weakly interacting massive particle (WIMP) dark matter annihilation and decay has become a multipronged area of research not only targeting a diverse selection of astrophysical objects, but also taking advantage of the entire electromagnetic spectrum. The decay of WIMP particles into standard model particles has been suggested as a possible channel for synchrotron emission to be detected at low radio frequencies. Here, we present the stacking analysis of a sample of 33 dwarf spheroidal (dSph) galaxies with low-frequency (72-231 MHz) radio images from the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey. We produce radial surface brightness profiles of images centred upon each dSph galaxy with background radio sources masked. We remove 10 fields from the stacking due to contamination from either poorly subtracted, bright radio sources or strong background gradients across the field. The remaining 23 dSph galaxies are stacked in an attempt to obtain a statistical detection of any WIMP-induced synchrotron emission in these systems. We find that the stacked radial brightness profile does not exhibit a statistically significant detection above the 95 per cent confidence level of ∼1.5 mJy beam−1. This novel technique shows the potential of using low-frequency radio images to constrain fundamental properties of particle dark matter

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.

The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer

Murchison Widefield Array and XMM-Newton observations of the Galactic supernova remnant G5.9+3.1

Aims. In this paper we discuss the radio continuum and X-ray properties of the so-far poorly studied Galactic supernova remnant (SNR) G5.9 + 3.1. Methods. We present the radio spectral energy distribution (SED) of the Galactic SNR G5.9 + 3.1 obtained with the Murchison Widefield Array (MWA). Combining these new observations with the surveys at other radio continuum frequencies, we discuss the integrated radio continuum spectrum of this particular remnant. We have also analyzed an archival XMM-Newton observation, which represents the first detection of X-ray emission from this remnant. Results. The SNR SED is very well explained by a simple power-law relation. The synchrotron radio spectral index of G5.9 + 3.1 is estimated to be 0.42 ± 0.03 and the integrated flux density at 1 GHz to be around 2.7 Jy. Furthermore, we propose that the identified point radio source, located centrally inside the SNR shell, is most probably a compact remnant of the supernova explosion. The shell-like X-ray morphology of G5.9 + 3.1 as revealed by XMM-Newton broadly matches the spatial distribution of the radio emission, where the radio-bright eastern and western rims are also readily detected in the X-ray while the radio-weak northern and southern rims are weak or absent in the X-ray. Extracted MOS1+MOS2+PN spectra from the whole SNR as well as the north, east, and west rims of the SNR are fit successfully with an optically thin thermal plasma model in collisional ionization equilibrium with a column density NH ~ 0.80 × 1022 cm−2 and fitted temperatures spanning the range kT ~ 0.14–0.23 keV for all of the regions. The derived electron number densities ne for the whole SNR and the rims are also roughly comparable (ranging from ~0.20f−1∕2 to ~0.40f−1∕2 cm−3, where f is the volume filling factor). We also estimate the swept-up mass of the X-ray emitting plasma associated with G5.9+3.1 to be ~46f−1∕2 M⊙.</jats:p