APPRAISAL OF THE INVESTMENT PROJECTS EFFICIENCY

The evaluation of efficiency of investment projects at RUP «BMZ» is given

EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE

The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol Regional Clinical TB Dispensary from 2014 to 2017. It was found out that regimens with bedaquiline were satisfactory tolerated, and the attempt to identify the agent causing adverse events within a multi-component chemotherapy regimen failed. The majority of adverse events were reversible, but they required temporary cancellation of chemotherapy in 5 patients with the consequent continuation of treatment with this regimen after adverse events were managed. The evaluation of treatment efficiency with 6-month treatment with bedaquiline showed sputum conversion in 94.4% of cases and healing of cavities in 72.2%

The calculation of features of X-ray radiation

On the basis of theoretical research an algorithm was received, allowing to calculate the features of X-ray radiation: spectral resolution, mean photon energy, homogeneity coefficient, the first and the second half-value layer by means of building a spectrum of bremsstrahlung X-ray radiation and determining the mean photon energy disregarding and taking into account the filter, required for the determination of 1st HVL; an analysis and comparison of calculated features of standard X-ray radiations of series L, N, W and H with similar features, provided in DSTU ISO 4037-1:2006 were carried out; the criterion of applicability of the given algorithm – the homogeneity coefficient value – was determined on the basis of the analysis and comparison