The resummation of inter-jet energy flow for gaps-between-jets processes at HERA

We calculate resummed perturbative predictions for gaps-between-jets processes and compare to HERA data. Our calculation of this non-global observable needs to include the effects of primary gluon emission (global logarithms) and secondary gluon emission (non-global logarithms) to be correct at the leading logarithm (LL) level. We include primary emission by calculating anomalous dimension matrices for the geometry of the specific event definitions and estimate the effect of non-global logarithms in the large $N_c$ limit. The resulting predictions for energy flow observables are consistent with experimental data.Comment: 31 pages, 4 figures, 2 table

Low levels of urinary psa better identify prostate cancer patients

SIMPLE SUMMARY: Elevated PSA levels in blood tests are the gold standard for early prostate cancer detection, but its lack of specificity limits its clinical use as a mass screening test. The paradox is that it has long been known that advanced prostate cancers can lose PSA expression. We have observed that in the presence of tumors, the prostate produces and secretes less PSA than in healthy or benign conditions. Therefore, the PSA evaluation in urine provided more accurate information on the presence of prostate tumors than the blood test, representing a new method for the screening of prostate cancer. ABSTRACT: Serum prostatic specific antigen (PSA) has proven to have limited accuracy in early diagnosis and in making clinical decisions about different therapies for prostate cancer (PCa). This is partially due to the fact that an increase in PSA in the blood is due to the compromised architecture of the prostate, which is only observed in advanced cancer. On the contrary, PSA observed in the urine (uPSA) reflects the quantity produced by the prostate, and therefore can give more information about the presence of disease. We enrolled 574 men scheduled for prostate biopsy at the urology clinic, and levels of uPSA were evaluated. uPSA levels resulted lower among subjects with PCa when compared to patients with negative biopsies. An indirect correlation was observed between uPSA amount and the stage of disease. Loss of expression of PSA appears as a characteristic of prostate cancer development and its evaluation in urine represents an interesting approach for the early detection of the disease and the stratification of patients

Effects of Higher-Order Threshold Corrections in High-E_T Jet Production

Results for higher-order threshold enhancements in high-E_T jet production in hadron-hadron collisions are presented. Expressions are given for the next-to-next-to-leading order (NNLO) threshold corrections to the single-jet inclusive cross section at next-to-leading logarithmic (NLL) accuracy. The corrections are found to be small for the specific choice of E_T/2 for the factorization and renormalization scales, and the corrected cross section shows a substantial reduction of the scale dependence. A comparison to experimental results from the Tevatron is presented.Comment: 24 pages LaTeX, 5 figure

Predictors of Bone Metastases at68Ga-PSMA-11 PET/CT in Hormone-Sensitive Prostate Cancer (HSPC) Patients with Early Biochemical Recurrence or Persistence

Prostate-specific-membrane-antigen/positron-emission-tomography (PSMA-PET) can accurately detect disease localizations in prostate cancer (PCa) patients with early biochemical recurrence/persistence (BCR/BCP), allowing for more personalized image-guided treatments in oligometastatic patients with major impact in the case of bone metastases (BM). Therefore, this study aimed to identify predictors of BM at PSMA-PET in early-BCR/BCP hormone-sensitive PCa (HSPC) patients, previously treated with radical intent (radiotherapy or radical prostatectomy ± salvage-radiotherapy (SRT)). A retrospective analysis was performed on 443 (68)Ga-PSMA-11-PET/CT scans. The cohort median PSA at PET-scan was 0.60 (IQR: 0.38–1.04) ng/mL. PSMA-PET detection rate was 42.0% (186/443), and distant lesions (M1a/b/c) were found in 17.6% (78/443) of cases. BM (M1b) were present in 9.9% (44/443) of cases, with 70.5% (31/44) showing oligometastatic spread (≤3 PSMA-positive lesions). In the multivariate binary logistic regression model (accuracy: 71.2%, Nagelkerke-R(2): 13%), T stage ≥ 3a (OR: 2.52; 95% CI: 1.13–5.60; p = 0.024), clinical setting (previous SRT vs. first-time BCR OR: 2.90; 95% CI: 1.32–6.35; p = 0.008), and PSAdt (OR: 0.93; 95% CI: 0.88–0.99; p = 0.026) were proven to be significant predictors of bone metastases, with a 7% risk increment for each single-unit decrement of PSAdt. These predictors could be used to further refine the indication for PSMA-PET in early BCR/BCP HSPC patients, leading to higher detection rates of bone disease and more personalized treatments

Dijet Rapidity Gaps in Photoproduction from Perturbative QCD

By defining dijet rapidity gap events according to interjet energy flow, we treat the photoproduction cross section of two high transverse momentum jets with a large intermediate rapidity region as a factorizable quantity in perturbative QCD. We show that logarithms of soft gluon energy in the interjet region can be resummed to all orders in perturbation theory. The resummed cross section depends on the eigenvalues of a set of soft anomalous dimension matrices, specific to each underlying partonic process, and on the decomposition of the scattering according to the possible patterns of hard color flow. We present a detailed discussion of both. Finally, we evaluate numerically the gap cross section and gap fraction and compare the results with ZEUS data. In the limit of low gap energy, good agreement with experiment is obtained.Comment: 37 pages, Latex, 17 figure

On the breaking of collinear factorization in QCD

We investigate the breakdown of collinear factorization for non-inclusive observables in hadron-hadron collisions. For pure QCD processes, factorization is violated at the three-loop level and it has a structure identical to that encountered previously in the case of super-leading logarithms. In particular, it is driven by the non-commutation of Coulomb/Glauber gluon exchanges with other soft exchanges. Beyond QCD, factorization may be violated at the two-loop level provided that the hard subprocess contains matrix element contributions with phase differences between different colour topologies.Comment: Version 2: minor improvements for journal publicatio

Transperineal versus transrectal prostate biopsy for predicting the final laterality of prostate cancer : are they reliable enough to select patients for focal therapy? Results from a multicenter international study

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Soft-gluon resummation for heavy quark production in hadronic collisions

We discuss the heavy quark production cross section near partonic threshold in hadronic collisions, including the resummation of leading and next-to-leading logarithms arising from soft gluon emission. We show how to handle the complications due to the non-universal non-leading logarithms. We give analytical results for the $q {\bar q}$ partonic subprocess and numerical results in the DIS scheme for top quark production at the Fermilab Tevatron where the $q {\bar q}$ channel dominates.Comment: 16 pages LaTeX including 4 eps figures, a few equations and some text added, figure 3 corrected, other small change

Small non-coding RNA profiling in plasma extracellular vesicles of bladder cancer patients by next-generation sequencing: Expression levels of miR-126-3p and piR-5936 increase with higher histologic grades

Bladder cancer (BC) is the tenth most frequent cancer worldwide. Due to the need for recurrent cystoscopies and the lack of non-invasive biomarkers, BC is associated with a high management burden. In this respect, small non-coding RNAs (sncRNAs) have been investigated in urine as possible biomarkers for BC, but in plasma their potential has not yet been defined. The expression levels of sncRNAs contained in plasma extracellular vesicles (EVs) from 47 men with BC and 46 healthy controls were assessed by next-generation sequencing. The sncRNA profiles were compared with urinary profiles from the same subjects. miR-4508 resulted downregulated in plasma EVs of muscle-invasive BC patients, compared to controls (adj-p = 0.04). In World Health Organization (WHO) grade 3 (G3) BC, miR-126-3p was upregulated both in plasma EVs and urine, when compared to controls (for both, adj-p < 0.05). Interestingly, two sncRNAs were associated with the risk class: miR-4508 with a downward trend going from controls to high risk BC, and piR-hsa-5936 with an upward trend (adj-p = 0.04 and adj-p = 0.05, respectively). Additionally, BC cases with low expression of miR-185-5p and miR-106a-5p or high expression of miR-10b-5p showed shorter survival (adj-p = 0.0013, adj-p = 0.039 and adj-p = 0.047, respectively). SncRNAs from plasma EVs could be diagnostic biomarkers for BC, especially in advanced grade