630 research outputs found
Optical phase coherent timing of the Crab nebula pulsar with Iqueye at the ESO New Technology Telescope
The Crab nebula pulsar was observed in 2009 January and December with a novel
very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New
Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we
computed accurate phase coherent timing solutions for the two observing runs
and over the entire year 2009. Our statistical uncertainty on the determination
of the phase of the main pulse and the rotational period of the pulsar for
short (a few days) time intervals are s and ~0.5 ps,
respectively. Comparison with the Jodrell Bank radio ephemerides shows that the
optical pulse leads the radio one by ~240 s in January and ~160 s in
December, in agreement with a number of other measurements performed after
1996. A third-order polynomial fit adequately describes the spin-down for the
2009 January plus December optical observations. The phase noise is consistent
with being Gaussian distributed with a dispersion of s in most observations, in agreement with theoretical expectations for
photon noise-induced phase variability.Comment: 10 pages, 5 figures. Accepted for publication in Monthly Notices of
the Royal Astronomical Societ
Finite element analysis of ground deformation due to dike intrusion with applications to Mt. Etna volcano
A 2D finite elements study was carried out to analyse the effects caused by dike intrusion inside a heterogeneous medium and with a realistic topography of Mt. Etna volcano. Firstly, the method (dimension domain, elements type) was calibrated using plane strain models in elastic half-spaces; the results were compared with those obtained from analytical dislocation models. Then the effects caused both by the topographic variations and the presence of multi-layered medium on the surface, were studied. In particular, an application was then considered to Mt. Etna by taking into account the real topography and the stratification deduced from seismic tomography. In these conditions, the effects expected by the dike, employed to model the 2001 eruption under simple elastic half-space medium conditions, were computed, showing that topography is extremely important, at least in the near field
QuantEYE: The Quantum Optics Instrument for OWL
QuantEYE is designed to be the highest time-resolution instrument on ESO:s
planned Overwhelmingly Large Telescope, devised to explore astrophysical
variability on microsecond and nanosecond scales, down to the quantum-optical
limit. Expected phenomena include instabilities of photon-gas bubbles in
accretion flows, p-mode oscillations in neutron stars, and quantum-optical
photon bunching in time. Precise timescales are both variable and unknown, and
studies must be of photon-stream statistics, e.g., their power spectra or
autocorrelations. Such functions increase with the square of the intensity,
implying an enormously increased sensitivity at the largest telescopes.
QuantEYE covers the optical, and its design involves an array of
photon-counting avalanche-diode detectors, each viewing one segment of the OWL
entrance pupil. QuantEYE will work already with a partially filled OWL main
mirror, and also without [full] adaptive optics.Comment: 7 pages; Proceedings from meeting 'Instrumentation for Extremely
Large Telescopes', held at Ringberg Castle, July 2005 (T.Herbst, ed.
European Non-native Species in Aquaculture Risk Analysis Scheme - a summary of assessment protocols and decision support tools for use of alien species in aquaculture
The European Non-native Species in Aquaculture Risk Analysis Scheme (ENSARS) was developed in response to European 'Council Regulation No. 708/2007 of 11 June 2007 concerning use of alien and locally absent species in aquaculture' to provide protocols for identifying and evaluating the potential risks of using non-native species in aquaculture. ENSARS is modular in structure and adapted from non-native species risk assessment schemes developed by the European and Mediterranean Plant Protection Organisation and for the UK. Seven of the eight ENSARS modules contain protocols for evaluating the risks of escape, introduction to and establishment in open waters, of any non-native aquatic organism being used (or associated with those used) in aquaculture, that is, transport pathways, rearing facilities, infectious agents, and the potential organism, ecosystem and socio-economic impacts. A concluding module is designed to summarise the risks and consider management options. During the assessments, each question requires the assessor to provide a response and confidence ranking for that response based on expert opinion. Each module can also be used individually, and each requires a specific form of expertise. Therefore, a multidisciplinary assessment team is recommended for its completion
Aqueye optical observations of the Crab Nebula pulsar
We observed the Crab pulsar in October 2008 at the Copernico Telescope in
Asiago - Cima Ekar with the optical photon counter Aqueye (the Asiago Quantum
Eye) which has the best temporal resolution and accuracy ever achieved in the
optical domain (hundreds of picoseconds). Our goal was to perform a detailed
analysis of the optical period and phase drift of the main peak of the Crab
pulsar and compare it with the Jodrell Bank ephemerides. We determined the
position of the main peak using the steepest zero of the cross-correlation
function between the pulsar signal and an accurate optical template. The pulsar
rotational period and period derivative have been measured with great accuracy
using observations covering only a 2 day time interval. The error on the period
is 1.7 ps, limited only by the statistical uncertainty. Both the rotational
frequency and its first derivative are in agreement with those from the Jodrell
Bank radio ephemerides archive. We also found evidence of the optical peak
leading the radio one by ~230 microseconds. The distribution of phase-residuals
of the whole dataset is slightly wider than that of a synthetic signal
generated as a sequence of pulses distributed in time with the probability
proportional to the pulse shape, such as the average count rate and background
level are those of the Crab pulsar observed with Aqueye. The counting
statistics and quality of the data allowed us to determine the pulsar period
and period derivative with great accuracy in 2 days only. The time of arrival
of the optical peak of the Crab pulsar leads the radio one in agreement with
what recently reported in the literature. The distribution of the phase
residuals can be approximated with a Gaussian and is consistent with being
completely caused by photon noise (for the best data sets).Comment: 7 pages, 7 figures. Accepted for publication in Astronomy and
Astrophysic
Low levels of urinary psa better identify prostate cancer patients
SIMPLE SUMMARY: Elevated PSA levels in blood tests are the gold standard for early prostate cancer detection, but its lack of specificity limits its clinical use as a mass screening test. The paradox is that it has long been known that advanced prostate cancers can lose PSA expression. We have observed that in the presence of tumors, the prostate produces and secretes less PSA than in healthy or benign conditions. Therefore, the PSA evaluation in urine provided more accurate information on the presence of prostate tumors than the blood test, representing a new method for the screening of prostate cancer. ABSTRACT: Serum prostatic specific antigen (PSA) has proven to have limited accuracy in early diagnosis and in making clinical decisions about different therapies for prostate cancer (PCa). This is partially due to the fact that an increase in PSA in the blood is due to the compromised architecture of the prostate, which is only observed in advanced cancer. On the contrary, PSA observed in the urine (uPSA) reflects the quantity produced by the prostate, and therefore can give more information about the presence of disease. We enrolled 574 men scheduled for prostate biopsy at the urology clinic, and levels of uPSA were evaluated. uPSA levels resulted lower among subjects with PCa when compared to patients with negative biopsies. An indirect correlation was observed between uPSA amount and the stage of disease. Loss of expression of PSA appears as a characteristic of prostate cancer development and its evaluation in urine represents an interesting approach for the early detection of the disease and the stratification of patients
Bioactive triterpenes of protium heptaphyllum gum resin extract display cholesterol-lowering potential
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds
Bioactive triterpenes of protium heptaphyllum gum resin extract display cholesterol-lowering potential
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra-and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds
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