Development of a virtual preclinical practical curriculum for acquisition of skills in the use of rotary instruments for dental students

La pandemia SARS-CoV-2 obliga a buscar soluciones educativas no presenciales; sin embargo, la adquisición de habilidades necesarias en Odontología son difícilmente virtualizables. Este proyecto ofrece una alternativa viable de prácticas preclínicas a distancia.The SARS-CoV-2 pandemic has forced dental schools to find virtual educational solutions for students to gain competency in different areas. Specially important is the acquisition of skills in Dentistry; however, preclinical training is difficult to virtualize. This project offers a viable alternative for virtual preclinical practices.Depto. de Odontología Conservadora y PrótesisFac. de OdontologíaFALSEVicerrectorado de Calidad UCMsubmitte

Colgar la revista en la red

El objetivo principal del proyecto es posibilitar que todos los componentes del centro puedan acceder a su revista en versión impresa y electrónica. Además se quiere mejorar la competencia comunicativa del alumno; conocer y utilizar programas de procesamiento y edición de textos; desarrollar el espíritu crítico del alumno; y apreciar las posibilidades expresivas del trabajo periodístico y valorar los procesos creativos. El primer trimestre se dedica a conocer el periodismo escrito; en el segundo, se pone en práctica con la redacción de artículos, elaboración de materiales gráficos e inico de la maquetación; en el tercero, se termina de maquetar, se envía a imprenta y se pasan los materiales a formato electrónico para publicarlos en la página web. También se colabora en el periódico entercentros del ayuntamiento. Durante el proceso, se observan las reacciones suscitadas en la comunidad educativa, se valora la calidad de los contenidos, si la revista responde a la realidad del centro y la facilidad de navegación.Madrid (Comunidad Autónoma). Consejería de EducaciónMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistance profile of a large cohort of patients failing DAA-based treatments, and investigate the relationship between HCV subtype and failure, as an aid to optimizing management of these patients. A new, standardized HCV-RAS testing protocol based on deep sequencing was designed and applied to 220 previously subtyped samples from patients failing DAA treatment, collected in 39 Spanish hospitals. The majority had received DAA-based interferon (IFN) α-free regimens; 79% had failed sofosbuvir-containing therapy. Genomic regions encoding the nonstructural protein (NS) 3, NS5A, and NS5B (DAA target regions) were analyzed using subtype-specific primers. Viral subtype distribution was as follows: genotype (G) 1, 62.7%; G3a, 21.4%; G4d, 12.3%; G2, 1.8%; and mixed infections 1.8%. Overall, 88.6% of patients carried at least 1 RAS, and 19% carried RAS at frequencies below 20% in the mutant spectrum. There were no differences in RAS selection between treatments with and without ribavirin. Regardless of the treatment received, each HCV subtype showed specific types of RAS. Of note, no RAS were detected in the target proteins of 18.6% of patients failing treatment, and 30.4% of patients had RAS in proteins that were not targets of the inhibitors they received. HCV patients failing DAA therapy showed a high diversity of RAS. Ribavirin use did not influence the type or number of RAS at failure. The subtype-specific pattern of RAS emergence underscores the importance of accurate HCV subtyping. The frequency of "extra-target" RAS suggests the need for RAS screening in all three DAA target regions