Antibacterial activity of Nigerian medicinal plants as panacea for antibiotic resistance: A systematic review

Background & Aim: Antibiotic resistance is one of the global public health threats facing modern health care system. The development of new effective agents has been challenging. Thus, the interest in the use of medicinal plants for the treatment of bacterial infections has increased. Therefore, the aim of this study was to review Nigerian medicinal plants with antibacterial activity. Experimental: This study retrieved data from published articles on Nigerian medicinal plants with antibacterial activity. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were adopted. A systematic search of PUBMED CENTRAL was conducted. The included studies were those published in peer-reviewed English language journals between 1st January 2000 and 31st December 2020 and reported on the key terms; Nigerian medicinal plants with antibacterial activity. Results: The database searches yielded a total of 817 results, and 765 articles were ineligible. After reviewing relevant titles and abstracts, a total of 52 articles on antibacterial were retrieved for full text review. After extensive review of each article, 13 articles were excluded and a total of 39 articles were retained. Furthermore, 4 articles were also removed due to lack of specific compounds stated. Finally, only 35 articles met the inclusion criteria for the assessment of antibacterial activity of Nigerian medicinal plants. The narrative synthesis of the included studies revealed different plants families with broad activities against gram-positive and gram-negative bacteria. Among the bacterial isolates, Staphylococcus aureus was tested more, followed by Escherichia coli and Pseudomonas aeruginosa and the bacteria were subjected to 97 medicinal plants species for antibacterial activity. Recommended applications/industries: The results from this study reveal that many Nigerian medicinal plants contain bioactive compounds with potentials of antibacterial activity and suggest that they could be employed as alternative in the treatment of bacterial infections after safety profiles is appraised

Academic Stress and Parental Pressure as Predictors of Psychological Health in Covid-19 Emergency Times among School Children with Intellectual Disabilities in Calabar Metropolis, Cross River State, Nigeria: The Implication for Counseling

Background: Academic stress and parental pressure have been shown to be important factors associated with psychological health. However, the internal mechanism between them is still not clear. Aim: This study assessed the joint significant influence of the predictor variables (academic stress and parental pressure) as predictors of psychological health in COVID-19 emergency times among school children with disabilities in Calabar metropolis, Cross River State, Nigeria: The implication for counseling. One study objective was stated, and one statement of hypothesis was posed. A literature review was carried out based on the variable under study. Method: The research design that was adopted in this study is correlational research design. A simple random sampling technique was adopted to select the 234 respondents sampled for the study from a population of 2,344. A validated 35-item four-point modified Likert scale questionnaire was the instrument used for data collection. The face and content validity of the instrument was established by experts in Test and Measurement. The reliability estimates 0.89 of the instruments were established using the Cronbach Alpha method. A multiple Linear regression statistical tool was used to test the hypotheses formulated for the study. The hypothesis was tested at a 0.05 level of significance. Results: The results obtained from the data analysis revealed that there is a joint significant influence of the predictor variables (academic stress and parental pressure) on psychological health in COVID-19 emergency times among school children with learning disabilities. Conclusion: Sometimes, stress and pressure can be motivating at the mild stage. However, at the severe stage, it could lead to frustration, social pressure, family workload, and cognitive overload, which in turn influences an individual to use and abuse substances in order to escape from unpleasant feelings of life situations. It was recommended that Parents should advise students on how to perform well academically rather than setting standards that may put so much pressure on students, which may have a negative impact on the psychological health of the students

Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

Background The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic; characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic; and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95$7·3 trillion (95% UI 7·2–7·4) in 2019; 293·7 times the $24·8 billion (95$43·1 billion in development assistance was provided to maintain or improve health. The pandemic led to an unprecedented increase in development assistance targeted towards health; in 2020 and 2021, $1·8 billion in DAH contributions was provided towards pandemic preparedness in LMICs, and$37·8 billion was provided for the health-related COVID-19 response. Although the support for pandemic preparedness is 12·2% of the recommended target by the High-Level Independent Panel (HLIP), the support provided for the health-related COVID-19 response is 252·2% of the recommended target. Additionally, projected spending estimates suggest that between 2022 and 2026, governments in 17 (95% UI 11–21) of the 137 LMICs will observe an increase in national government health spending equivalent to an addition of 1% of GDP, as recommended by the HLIP. Interpretation There was an unprecedented scale-up in DAH in 2020 and 2021. We have a unique opportunity at this time to sustain funding for crucial global health functions, including pandemic preparedness. However, historical patterns of underfunding of pandemic preparedness suggest that deliberate effort must be made to ensure funding is maintained

Studies on the Impact of Microplastics in Freshwater Systems: Biota Could Be Vital Indicators in Delta State, Nigeria

Microplastics have impacted freshwater system globally. Despite the global concern about microplastic pollution, only a little is evidenced in research on the occurrence and intensity of pollution in research. This study determined the effects of microplastics on aquatic water bodies was determined using plants as bio-indicator. The study was conducted bimonthly (June- August) to examine the occurrence of microplastics. Physicochemical parameters and biochemical parameters of plants were analyzed using standard methods. Hydrogen ion concentrations of the water sources were mildly acidic (5.6±0.15 and 5.49±0.19), and turbidity levels were notably high (71.00±4.20 NTU and 92.70 ±4.32 NTU) in lotic and lentic water bodies respectively. Dissolved oxygen and biological oxygen demand were significantly compared within aquatic systems (p<0.05). Water hyacinth- Pontederia crassipes Mart (former Eichhornia crassipes) exhibited higher levels of soluble sugar at 110.34±3.32 mg/L in lotic water body compared to water leaf- Talinum triangulare (Jacq.) Willd, 70.44±4.78 mg/L in lentic water. Total chlorophyll levels and water retention capacity were lower in lotic water at 37.90±2.35 and 2.08±0.21 respectively. Ascorbic acid levels were higher in lotic water (308.00±12.34 mg/100g). Chironomus sp. and Nais sp. were commonly encountered. The vital role of Chironomus sp. and Nais sp. should not be underestimated as bioindicators in freshwater systems. Hence, they should be further investigated in different freshwater ecosystems