Licensed Integrated Examination "Step 1. Dentology" in the Bogomolets National Medical University as Education Quality Control Indicator: Inter-dissiplanal Integration. Monitoring Aspect

The study considers pedagogical means of students' readiness to the licensed integrated exam “Step 1. Stomatology”, used at higher medical educational institutions. The results of licensed integrated exam “Step 1. Stomatology” of students, taught in the official language, for 2015–2017 were analyzed. The disciplines, most complicated for students, were determined by subtests, based on the results of the independent state exam. The dynamics and successfulness of total modular controls in biological chemistry by students of the stomatological department of the National medical university, named after O.O. Bogomolets, were studied. The main causes of their academic results on biological chemistry were determined. The comparative analysis of stomatological students' results in the discipline “Biological chemistry” and their successfulness in the same discipline within the licensed integrated exam “Step 1. Stomatology” was mad

Synthesis, in silico and in vitro Evaluation of Novel Oxazolopyrimidines as Promising Anticancer Agents

New potential bioactive oxazolopyrimidines have been synthesized using two main approaches: the pyrimidine ring annulation on a functionalized oxazole and the benzoyl bromide trimerization followed by rearrangement and formation of the oxazolo[5,4-d]pyrimidine scaffold. The docking analyzes have shown that 7-piperazine substituted oxazolo[4,5-d]pyrimidines 8a–8c could be potential VEGFR2 inhibitors with high free energy of ligand–protein complex formation (ΔG: −10.1, −9.6, −9.8 kcal/mol, respectively). In vitro antitumor assays confirmed theoretical predictions that oxazolo[4,5-d]pyrimidines 8a–8c containing positively charged piperazine moiety should demonstrate significantly higher cytotoxic effects. 4-[5-(4-Chlorophenyl)-2-phenyl[1,3]oxazolo[4,5-d]pyrimidin-7-yl]piperazin-1-ium trifluoroacetate (8c) exhibited a slightly higher antiproliferative effect (IC50=0.21 μm) than doxorubicin (IC50=0.36 μm) on MDA-MB-231 cell line and has relatively good results on OVCAR-3 (IC50=1.7 μm) and HCT-116 (IC50=0.24 μm) cells