Pathways for irrigation development : policies and irrigation performance in Tanzania

This research was commissioned by FANRPAN as part of the project Increasing Irrigation Water Productivity in Mozambique, Tanzania and Zimbabwe through On-Farm Monitoring, Adaptive Management and Agricultural Innovation Platforms. The Australian government funds the project through the Australian International Food Security Research Centre of the Australian Centre for International Agricultural Research, with additional contributions from participating organisations. The Australian National University leads the project.This report presents the findings of a rapid review to determine the policies and politics that have shaped irrigation practice and performance in Tanzania over the past 40–50 years. The review seeks to understand drivers (and blockages) of change with respect to improving sector performance and to identify opportunities for innovation. We also consider who has benefited and lost from public investments, and how these investments could better contribute to poverty reduction, economic growth and climate resilience. The focus of the analysis is small-scale irrigation schemes managed by farmers and supported by the state. We are particularly interested in the role irrigation plays in contexts characterised by high rainfall variability and increasing (physical or economic) water scarcity, such as the upper Rufiji Basin. The desk-based review was supplemented with in-country interviews at national and district level (Iringa), and brief site visits to three schemes in the Ruaha sub-catchment of the Rufiji (also Iringa district)

Managing rivers for multiple benefits – a coherent approach to research, policy and planning

Rivers provide water for irrigation, domestic supply, power generation and industry as well as a range of other ecosystem services and intrinsic and biodiversity values. Managing rivers to provide multiple benefits is therefore foundational to water security and other policy priorities. Because river flow is often insufficient to meet all needs fully, water management experts have acknowledged the need for trade-offs in river management. Ecosystem scientists have classified and quantified goods and services that rivers provide to society. However, they have seldom examined the way in which water management infrastructure and institutional arrangements harness and direct goods and services to different groups in society. Meanwhile, water management paradigms have often considered freshwater ecosystems as rival water users to society or a source of natural hazards and have underplayed the role healthy ecosystems play in providing multiple social and economic benefits. We argue that physical and social structures and processes are necessary to realize multiple benefits from river ecosystems, and that these structures and processes, in the form of (formal and informal) institutions and (gray and green) infrastructure, shape how benefits accrue to different groups in society. We contend that institutions and infrastructure are in turn shaped by political economy. We suggest a more coherent framework for river management research, policy and planning that focuses on (a) the ways in which political economy, institutions and infrastructure mediate access and entitlements to benefits derived from ecosystem services, and (b) the feedbacks and trade-offs between investments in physical and social structures and processes

A hidden crisis: strengthening the evidence base on the current failures of rural groundwater supplies

New ambitious international goals for universal access to safe drinking water depend critically on the ability of development partners to accelerate and sustain access to groundwater. However, available evidence (albeit fragmented and methodologically unclear) indicates >30% of new groundwater-based supplies are non-functional within a few years of construction. Critically, in the absence of a significant systematic evidence base or analysis on supply failures, there is little opportunity to learn from past mistakes, to ensure more sustainable services can be developed in the future. This work presents a new and robust methodology for investigating the causes of non-functionality, developed by an interdisciplinary team as part of an UPGro catalyst grant. The approach was successfully piloted within a test study in NE Uganda, and forms a basis for future research to develop a statistically significant systematic evidence base to unravel the underlying causes of failure

Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19

Importance: Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence of the association of recent cancer treatment and cancer type with COVID-19 mortality. // Objective: To evaluate whether systemic anticancer treatments (SACTs), tumor subtypes, patient demographic characteristics (age and sex), and comorbidities are associated with COVID-19 mortality. // Design, Setting, and Participants: The UK Coronavirus Cancer Monitoring Project (UKCCMP) is a prospective cohort study conducted at 69 UK cancer hospitals among adult patients (≥18 years) with an active cancer and a clinical diagnosis of COVID-19. Patients registered from March 18 to August 1, 2020, were included in this analysis. // Exposures: SACT, tumor subtype, patient demographic characteristics (eg, age, sex, body mass index, race and ethnicity, smoking history), and comorbidities were investigated. // Main Outcomes and Measures: The primary end point was all-cause mortality within the primary hospitalization. // Results: Overall, 2515 of 2786 patients registered during the study period were included; 1464 (58%) were men; and the median (IQR) age was 72 (62-80) years. The mortality rate was 38% (966 patients). The data suggest an association between higher mortality in patients with hematological malignant neoplasms irrespective of recent SACT, particularly in those with acute leukemias or myelodysplastic syndrome (OR, 2.16; 95% CI, 1.30-3.60) and myeloma or plasmacytoma (OR, 1.53; 95% CI, 1.04-2.26). Lung cancer was also significantly associated with higher COVID-19–related mortality (OR, 1.58; 95% CI, 1.11-2.25). No association between higher mortality and receiving chemotherapy in the 4 weeks before COVID-19 diagnosis was observed after correcting for the crucial confounders of age, sex, and comorbidities. An association between lower mortality and receiving immunotherapy in the 4 weeks before COVID-19 diagnosis was observed (immunotherapy vs no cancer therapy: OR, 0.52; 95% CI, 0.31-0.86). // Conclusions and Relevance: The findings of this study of patients with active cancer suggest that recent SACT is not associated with inferior outcomes from COVID-19 infection. This has relevance for the care of patients with cancer requiring treatment, particularly in countries experiencing an increase in COVID-19 case numbers. Important differences in outcomes among patients with hematological and lung cancers were observed

Social vulnerability in three high-poverty climate change hot spots: What does the climate change literature tell us?

This paper reviews the state of knowledge on social vulnerability to climate change in three hot spots (deltas, semi-arid regions and snowpack- or glacier-fed river basins) in Africa, Central Asia and South Asia, using elements of systematic review methods. Social vulnerability is defined as a dynamic state of societies comprising exposure, sensitivity and adaptive capacity. We examine whether the hot spots have specific characteristics that tend to increase or decrease social vulnerability, consider suitable scales of analysis for understanding vulnerability, and explore the conceptions of vulnerability adopted in the climate change literature and the nature of the insights this generates. Finally, we identify knowledge gaps in this literature. All three hot spots are characterized by high levels of natural resource dependence, with increasing environmental degradation. They also exhibit unequal policies and patterns of development, which benefit certain segments of society while making others more vulnerable. Vulnerability is driven by multiple factors operating at different scales; however, characterization of cross-scalar interactions is poorly developed in the majority of studies reviewed. Most studies are either large scale, such as broad comparisons of vulnerability across countries, or local, documenting community-level processes. Detailed understanding of the interactions between climate change impacts on natural systems, and socio-economic trajectories, including adaptation, also emerges as a knowledge gap

Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development

Suppressor of cytokine signaling 1 (SOCS1) has been shown to play important roles in the immune system. It acts as a key negative regulator of signaling via receptors for IFNs and other cytokines controlling T cell development, as well as Toll receptor signaling in macrophages and other immune cells. To gain further insight into SOCS1, we have identified and characterized the zebrafish socs1 gene, which exhibited sequence and functional conservation with its mammalian counterparts. Initially maternally derived, the socs1 gene showed early zygotic expression in mesodermal structures, including the posterior intermediate cell mass, a site of primitive hematopoiesis. At later time points, expression was seen in a broad anterior domain, liver, notochord, and intersegmental vesicles. Morpholino-mediated knockdown of socs1 resulted in perturbation of specific hematopoietic populations prior to the commencement of lymphopoiesis, ruling out T cell involvement. However, socs1 knockdown also lead to a reduction in the size of the developing thymus later in embryogenesis. Zebrafish SOCS1 was shown to be able to interact with both zebrafish Jak2a and Stat5.1 in vitro and in vivo. These studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2-Stat5 pathway