Association Between Plasma Levels of Fibrinogen and the Presence and Severity of Coronary Artery Ectasia

Objective The aim of this study was to investigate the plasma fibrinogen levels in patients with isolated coronary artery ectasia (CAE).Materialsand MethodsThe study population included 154 patients, of whom 52 had isolated CAE, 52 had stable coronary artery disease (CAD) and 50 had normal coronary arteries (NCA). Theseverity of isolated CAE was determined using the Markis classification. All the subjects underwent complete physical examinations, including a detailed medical history,complete blood count and biochemical parameters. Plasma fibrinogen levels also were measured in all subjects.Results The baseline characteristics of the three groups were similar. Plasma fibrinogen levels were significantly higher in the CAE group and CAD group than in the NCA group(383.3 ± 53.0 mg/dl and 400.8 ± 50.6 mg/dl vs 324.0 ± 56.4 respectively, p 325 mg/dl identified patientswith isolated CAE.Conclusions Plasma fibrinogen is an easily measurable systemic inflammatory biomarker that is independently associated with CAE presence and severity. This suggests that fibrinogenmay be involved in the pathophysiology of CAE.Amaç Bu çalışmanın amacı izole koroner arter ektazisi (KAE) olan hastalarda plazma fibrinojen düzeylerini araştırmaktı. Gereç ve Yöntemler Çalışma popülasyonunda 52’si izole KAE, 52’sinde koroner arter hastalığı (KAH) ve 50’sinde normal koroner arter (NKA) bulunan 154 hasta vardı. İzole KAE ciddiyeti Markis sınıflandırması kullanılarak belirlendi. Tüm hastalardan ayrıntılı tıbbi öykü alındı ve eksiksiz fizik muayene yapıldı. Tam kan sayımı ve biyokimyasal parametreler değerlendirildi. Tüm hastaların plazma fibrinojen düzeyleri de ölçüldü. Bulgular Üç grubun temel özellikleri benzerdi. Plazma fibrinojen düzeyleri KAE grubunda ve KAH grubunda NKA grubuna göre anlamlı derecede yüksekti (sırasıyla 383.3 ± 53.0 mg / dl ve 400.8 ± 50.6 mg / dl vs 324.0 ± 56.4, p 325 mg / dl olmasının KAE hastalarını tanımladığı saptandı. Sonuç Plazma fibrinojeni; KAE varlığı ve şiddeti ile bağımsız bir şekilde ilişkili olan, kolayca ölçülebilen sistemik inflamatuar bir biyobelirteçtir. Bu sonuçlar, fibrinojenin KAE patofizyolojisinde rol oynayabileceğini göstermektedir

From Clinical Misdiagnosis to Electrophysiological Diagnosis: Two Male Asystole Cases

Differential diagnosis of epilepsy and syncope may be difficult. Arrhythmias such as asystole, or ventricular fibrillation, may lead to cerebral hypoperfusion mimicking partial or secondary generalized tonic-clonic seizures. While performing an electroencephalogram (EEG) for epilepsy diagnosis, simultaneous electrocardiogram (ECG) recording may detect cardiac pathology. In this article, through 2 cases, who had cardiac asystole during the EEG, we demonstrate the importance of ECG during EEG. To rule out cardiac pathology in syncope cases, all necessary investigations must be done

Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

Objective: This study aimed to evaluate the serum gamma-glutamyltransferase (GGT) levels as an indirect marker of elevated oxidative stress in patients with dilated ascending aorta

Coronary Slow Flow Phenomenon Associated with High Serum Levels of Soluble CD40 Ligand and Urotensin II: A Multi-Marker Approach

Background: The aim of this study was to evaluate the serum soluble CD40 ligand (5CD4OL) levels, serum urotensin II levels, and serum leptin levels as an indirect indicator of endothelial dysfunction, inflammation, and atherosclerosis at the microvascular level, and the comparison of those values with those of the control group with a normal coronary flow pattern

The 6-Year Single-Center Cardiac Electrophysiologic Study Experience on 1152 Patients for Cardiac Arrhythmia Adiagnosis and Treatment

Objective: Cardiac electrophysiology study EPS) is an invasive procedure performed for diagnosis and treatment of cardiac arrhythmias. The aim of our study was to assess our 6-year EPS experience and to compare our data with the complication rate published in the literature