Brain natriuretic peptide and applications in pediatrics

Natriüretik peptid ailesi (NP), sekiz ve daha fazla birbiriyle ilişkili peptidi içermektedir. Bunlar, 126 aminoasitten oluşan atrial natriüretik peptid (ANP) prohormonu, 108 aminoasitten oluşan brain natriüretik peptid (BNP) prohormonu, ve 126 aminoasitten oluşan C tipi natriüretik peptid (CNP) prohormonudur. Natriüretik peptidler son zamanlarda tanımlanmış olmalarına karşın potansiyel klinik öneme sahiptirler. Natriüretik peptidler, kardiyovasküler hastalıkların tanısı, tedaviye yanıtın ve prognozun değerlendirilmesinde yeni aday markerlardır.Family of natriuretic peptides (NP), consists of eight or more peptides associated with each other. These are, atrial natriuretic peptide (ANP) prohormone consisting of 126 amino acids; brain natriuretic peptide (BNP) prohormone consisting of 108 amino acids; C-type natriuretic peptide (CNP) prohormone consisting of 126 amino acids. Although recently identified, natriuretic peptides have potential clinical significance. Natriüretic peptide family seems to be a “novel candidate marker” for the assessment of diagnosis, therapeutic response and prognosis in cardiovascular disease

National guidelines for delivery room management.

The following guideline is designed to give recommendations for the routine care of all neonates immediately after delivery, and the resuscitation and delivery room approach of all high-risk infants in light of recent literature. The guideline has been prepared as three different parts. The first part is about routine procedures that have to be performed to all healthy term and preterm infants in delivery room care. The second part summaries the basic principles of resusucitation including the latest changes that were mentioned in the International Liaison Committee on Resuscitation (ILCOR)-2015 guideline. Recommendations about the delivery room management of rare clinical conditions have been discussed in the last part. The social, medical conditions, and the resourses of Turkey have also been taken into consideration in its preparation. We hope it will be useful for all pediatricians and neonatologists for use as a essential guideline in delivery room care

Cerebellar Herniation after Lumbar Puncture in Galactosemic Newborn

Cerebral edema resulting in elevated intracranial pressure is a well-known complication of galactosemia. Lumbar puncture was performed for the diagnosis of clinically suspected bacterial meningitis. Herniation of cerebral tissue through the foramen magnum is not a common problem in neonatal intensive care units because of the open fontanelle in infants. We present the case of a 3-week-old infant with galactosemia who presented with signs of cerebellar herniation after lumbar puncture

Mean platelet volumes in babies of preeclamptic mothers

Amaç: Bu çalışmada, preeklamptik anne bebekleri ile normal gebelikten olan bebeklerin ortalama trombosit hacimlerini (MPV) karşılaştırmak ve preeklamptik anne bebeklerinde ortaya çıkan trombositopeninin MPV ile ilişkisini araştırmak amaçlandı. Gereç ve Yöntem: Bu retrospektif çalışmaya gebelik yaşları benzer olan 63 yenidoğan alınmıştır. Bunlar trombositopeni gelişen 21 preeklamptik anne bebeği (Grup A), trombositopeni gelişmeyen 21 preeklamptik anne bebeği (Grup B) ve trombositopeni gelişmeyen 21 normal anne bebeği (Grup C) olmak üzere üç gruba ayrılmıştır. Hastaların yaşamın ilk 72 saati içerisinde bakılan hematolojik verileri tıbbi kayıtlarından elde edilmiştir. Olgular, doğum ağırlıkları, trombosit sayıları, MPV’leri açısından, karşılaştırıldılar. Bulgular: Her üç grubun da gestasyon yaşları benzerdi ve doğum ağırlıkları arasındaki fark anlamlı değildi. Grup A’nın trombosit sayısı anlamlı olarak düşüktü (p<0,001). Gruplar arasında trombosit sayısı düştükçe MPV nin arttığı ve Grup A bebeklerdeki MPV değerinin en yüksek olduğu gözlense de MPV ve trombosit sayıları arasında anlamlı korelasyon ve MPV değerleri açısından anlamlı bir fark saptanmadı (p=0,052). Sonuç: Trombosit hacmindeki artış trombosit yıkımının, azalma ise yapım yetersizliğinin bir göstergesi olarak kabul edilmektedir. Çalışmamızın sonuçlarına göre preeklamptik anne bebeklerinde saptanan trombositopeninin etyolojisinin trombosit hacmine bakarak açıklanamayacağını göstermektedir.Aim: The aim of this study was to compare the mean platelet volumes (MPV) in babies of preeclamptic and normal pregnant women and to investigate the correlation between thrombocytopenia and MPV in the babies of preeclamptic mothers. Materials and Method: A total of 63 newborns with similar gestational age were included in this retrospective study. They were divided into three groups as 21 babies of preeclamptic mothers with thrombocytopenia (Group A), 21 without thrombocytopenia (Group B) and 21 babies of normal pregnant women without thrombocytopenia (Group C). Hematologic data of the patients, obtained in the first 72 hours of their life, were achieved from their medical records. Groups were compared according to their birth weights, platelet counts and mean platelet volumes (MPV). Results: Gestastional age and birth weights of all groups were similar. The platelet count of group A was significantly lower (p<0.001). MPV seemed to increase as platelet counts decreased when the groups were compared. However no significant correlation was found between MPV and platelet counts and no significant difference between MPVs (p=0.052). Conclusion: Increase in MPV is accepted as a sign of platelet destruction and decrease as a sign of platelet production insufficiency. Our results showed that the etiology of thrombocytopenia in babies of preeclamptic mothers can not be explained with the help of MPV

Original Article The prevalence and diagnostic criteria of health-care associated infections in neonatal intensive care units in Turkey: A multicenter point- prevalence study

Background: Healthcare-acquired infections (HAIs) in the neonatal period cause substantial morbidity, mortality, and healthcare costs. Our purpose was to determine the prevalence of HAIs, antimicrobial susceptibility of causative agents, and the adaptivity of the Centres for Disease Control and Prevention (CDC) criteria in neonatal HAI diagnosis