Prescribers\u27 approval rate of pharmacist-initiated interventions to optimise patients\u27 clinical status of hypertension in the ambulatory care setting

This perspective, pre- and post-intervention study with a one-year follow-up primarily aimed to ascertain prescribers\u27 approval rate of pharmacists\u27 interventions and clinical status of hypertension following comprehensive medication management (CMM) intervention in the ambulatory care clinic. Between January 2018 and January 2022 overall 100 patients with hypertension and other comorbidities were referred to the CMM services at the Health Centre Zagreb – Centar (HCZC). Out of 275 interventions directed to prescribers, 73.1 % of interventions were approved, 12.4 % were rejected and 14.5 % were not reviewed. The percentage of patients with a blood pressure goal increased from 45 % at the initial consultation to 82.5 % at the patients’ latest encounter (p < 0.001). The average number of drug therapy problems (DTPs) per patient totaled 3.53 ± 1.80, where 98 % of patients had one or more DTPs, 48 % had 4 or more DTPs, whereas 26 % had 5 or more DTPs. Subtherapeutic dosage (32.6 %) and the need for additional drug therapy (30.9 %) were the two most commonly identified DTPs. These results reinforce the need to integrate pharmacy-led services in the primary care setting with the aim of improving patients\u27 health outcomes

N-glycosylation changes of plasma proteins and immunoglobulin G in bariatric surgery

Pretilost i dijabetes tipa 2 metabolički su poremećaji i jedni od glavnih javnozdravstvenih problema današnjice. Prati ih stanje kronične upale organizma, međusobno su čvrsto povezani te predstavljaju glavne indikacije za provođenje kirurškog zahvata za liječenje debljine. Navedenom kirurškom intervencijom dolazi do dugotrajne remisije dijabetesa tipa 2 i naglog pada tjelesne mase. Promjene u ljudskom N-glikomu mogu biti specifične za određena stanja u organizmu te se N-glikane proučava kao potencijalne biljege bolesti, njene progresije i odgovora na terapiju. S ciljem utvrđivanja povezanosti patofizioloških promjena nakon operacije s promjenama N-glikozilacije, u ovom istraživanju analizirani su i uspoređeni N-glikanski profili imunoglobulina G i ukupnih glikoproteina plazme desetorice ispitanika prije ugradnje želučane premosnice i šest mjeseci nakon operativnog zahvata. Dobiveni rezultati pokazuju određene promjene u N-glikozilacijskom profilu ispitanika između navedenih vremenskih točaka, međutim, opažene razlike nisu dosegle statističku značajnost, najvjerojatnije zbog ograničenog broja ispitanika. Nadalje, opažene glikozilacijske promjene kreću se u suprotnom smjeru od onih koje se obično uočavaju u upalnim stanjima, što sugerira da je došlo do smanjenja razine upale nakon provedenog operacijskog zahvata. N-glikani imunoglobulina G i glikoproteina plazme time dobivaju ulogu potencijalnih dijagnostičkih i prognostičkih biomarkera za liječenje pretilosti i dijabetesa tipa 2 barijatrijskim zahvatom.Obesity and type 2 diabetes are metabolic disorders which represent significant public healthcare burden globally. Both of them are associated with chronic low-grade inflammation, have a great interdependence and are the main indication for bariatric surgery. This procedure enables long-term type 2 diabetes remission and a significant loss of weight. Human N-glycome alterations can be specific for certain conditions, hence N-glycans are studied as potential prognostic markers for disease activity, progression and treatment. In order to determine associations between pathophysiological changes after surgery and alterations in N-glycosylation, we analyzed and compared immunoglobulin G and plasma glycoprotein N-glycan profiles from ten subjects, sampled at the baseline and six months after bariatric surgery. There was no statistically significant difference in N-glycome after the mentioned period, probably due to a limited number of examinees. According to the results, there are several clues that the reduction of inflammation has occurred among the patients. Immunoglobulin G and plasma glycoprotein N-glycans thereby show potential as diagnostic and prognostic biomarkers for bariatric treatment of obesity and type 2 diabetes

Prescribers’ approval rate of pharmacist-initiated interventions to optimise patients’ clinical status of hypertension in the ambulatory care setting

This perspective, pre- and post-intervention study with a one-year follow-up primarily aimed to ascertain prescribers’ approval rate of pharmacists’ interventions and clinical status of hypertension following comprehensive medication management (CMM) intervention in the ambulatory care clinic. Between January 2018 and January 2022 overall 100 patients with hypertension and other comorbidities were referred to the CMM services at the Health Centre Zagreb – Centar (HCZC). Out of 275 interventions directed to prescribers, 73.1 % of interventions were approved, 12.4 % were rejected and 14.5 % were not reviewed. The percentage of patients with a blood pressure goal increased from 45 % at the initial consultation to 82.5 % at the patients’ latest encounter (p < 0.001). The average number of drug therapy problems (DTPs) per patient totaled 3.53 ± 1.80, where 98 % of patients had one or more DTPs, 48 % had 4 or more DTPs, whereas 26 % had 5 or more DTPs. Sub-therapeutic dosage (32.6 %) and the need for additional drug therapy (30.9 %) were the two most commonly identified DTPs. These results reinforce the need to integrate pharmacy-led services in the primary care setting with the aim of improving patients’ health outcomes