3-[(E)-3-(2,4-Dichloro­phen­yl)prop-2-en­oyl]-4-hy­droxy-2H-chromen-2-one

In the title compound, C18H10Cl2O4, the chromen-2-one ring system is almost planar [maximum deviation = 0.028 (1) Å] and is inclined at an angle of 16.35 (4)° with respect to the benzene ring. The C=C bond has an E configuration. The mol­ecular conformation is stabilized by an almost symmetric intra­molecular O⋯H⋯O hydrogen bond and a C—H⋯O inter­action, both of which form S(6) ring motifs. In the crystal structure, mol­ecules are linked into sheets lying parallel to (100) via inter­molecular C—H⋯O hydrogen bonds. The crystal packing is further consolidated by π–π stacking inter­actions [centroid-to-centroid separation = 3.6615 (6) Å]

3-Methyl-4-[(E)-3-thien­ylmethyl­idene­amino]-1H-1,2,4-triazole-5(4H)-thione

The asymmetric unit of the title compound, C8H8N4S2, contains two crystallographically independent mol­ecules. The thio­phene ring of one mol­ecule is disordered over two positions with refined site occupancies of 0.6375 (19) and 0.3625 (19). One mol­ecule is almost planar and the other one is twisted, the dihedral angles between the thio­phene and triazole rings being 7.28 (7) and 48.9 (2)° [48.5 (4)° for the minor component], respectively. An intra­molecular C—H⋯S hydrogen bond stabilizes the mol­ecular conformation of the planar molecule. In the crystal, the two mol­ecules are inter­connected by N—H⋯S hydrogen bonds into dimers, which are further consolidated into chains along the b axis by C—H⋯N hydrogen bonds. Weak C–H⋯π and π–π inter­actions [centroid–centroid distance = 3.5149 (7) Å] are also observed

4-Hy­droxy-3-[(4-hy­droxy-6,7-dimethyl-2-oxo-2H-chromen-3-yl)(4-oxo-4H-chromen-3-yl)meth­yl]-6,7-dimethyl-2H-chromen-2-one

In the title compound, C32H24O8, the mol­ecular structure is disordered over two positions with refined site occupancies of 0.8746 (10) and 0.1254 (10). The mean plane of the three chromeno rings make dihedral angles with each other of 65.12 (4), 62.91 (4) and 59.70 (4)° in the major occupancy component and 59.1 (3), 66.1 (3) and 58.8 (3)° in the minor component. Intra­molecular O—H⋯O hydrogen bonds stabil­ize the mol­ecular structure and the crystal structure is stabilized by weak C–H⋯π and π–π inter­actions [centroid–centroid distances 3.496 (6)–3.672 (7) Å]

3-[5-(2,4-Dichloro­phen­yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-hy­droxy-2H-chromen-2-one

In the title compound, C24H16Cl2N2O3, the chromene ring system is almost planar, with a maximum deviation of 0.042 (1) Å. It makes dihedral angles of 3.72 (6), 73.37 (5) and 12.00 (5)° with the dihydro­pyrazole, benzene and phenyl rings, respectively. An intra­molecular O—H⋯N hydrogen bond forms an S(6) ring motif. In the crystal, mol­ecules are linked via C—H⋯O inter­actions, forming an infinite chain along the a axis. The crystal packing is further stabilized by a π–π stacking inter­action [centroid–centroid distance = 3.5471 (7) Å] and a Cl⋯Cl short contact [Cl⋯Cl = 3.214 (1) Å]

Assessment of thalassaemia service and community awareness in Kudat district

It was estimated that 3-5% of the Malaysian population are Beta-Thalassemia carriers, of which Malays are the majority. This study had probed into the service availability and efforts given in its procedures to detect the cases and carriers and detennine the awareness of Thalassemia among community living in rural area of Sabah, Malaysia. A cross-sectional survey on Thalassemia services was carried out in the hospital and health office of Kudat district, using quantitative and qualitative research methods .It was designed to assess the healthcare service on Thalassemia, characteristics of target population, procedures of services provided, knowledge and opinion of health personnel and communities staying in rural area of Kudat district. Purposive sample of villages were selected for the study, based on the presence of cases from secondary quantitative data. Out of the total 139 respondents, only 89 (60.9%) claimed to know what Thalassemia is but very few had ever tested for Thalassemia. Although half of the participants were aware of Thalassemia, their knowledge on Thalassemia was poor. Some of them knew how Thalassemia was transmitted through carrier of traits which can be diagnosed but did not understand the burden of its chronicity. Most of them had never seen or know about the treatment let alone the prognosis of the illness. Analytical study of the data had shown that there was a statistically significant association between the awareness of Thalassemia and individuals of different ages (p<0.001), occupation (p<0.002) and different education levels (p<0.00 1). In conclusion Thalassemia awareness among the rural community in Sabah, Malaysia was poor despite the high prevalence of the disease carriers. Much effort on Health Education and Health Promotion should be made to improve the awareness of this illness among the rural Malaysian community if the prevalence was to reduce in future

9-(7-Fluoro-4-oxo-4H-chromen-3-yl)-3,3,6,6-tetra­methyl-2,3,4,5,6,7,8,9-octa­hydro-1H-xanthene-1,8-dione

In the title compound, C26H25FO5, the terminal cyclo­hexane rings of the xanthene ring system adopt half-boat conformations. The 4H-chromene ring make a dihedral angle of 87.94 (5)° with the xanthene ring system and its carbonyl O atom lies above the xanthene O atom. In the crystal, mol­ecules are linked into ribbons propagating along the a-axis direction by C—H⋯O hydrogen bonds. Aromatic π–π stacking inter­actions [centroid–centroid distance = 3.7367 (12) Å] also occur

3-Hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)(thiophen-3-yl)methyl]-5,5-dimethylcyclohex-2-en-1-one

The asymmetric unit of the title compound, C21H26O4S, consists of two independent mol­ecules. In both mol­ecules, intra­molecular O—H⋯O hydrogen bonds stabilize the mol­ecular structure. In the crystal, each mol­ecule and its symmetry-related mol­ecule by twofold rotation form a dimer through a pair of inter­molecular C—H⋯O hydrogen bonds. In one of the mol­ecules, the thio­phene group is disordered over two sets of sites with occupancies of 0.735 (3) and 0.265 (3)

2-[(E)-(2,4-Dichloro­benzyl­idene)amino]­isoindoline-1,3-dione

In the title compound, C15H8Cl2N2O2, the mol­ecule adopts an E configuration about the central C=N double bond. The isoindoline ring is essentially planar, with a maximum deviation of 0.019 (2) Å. The dihedral angle between the isoindoline ring and the dichloro-substituted benzene ring is 6.54 (9)°. An intra­molecular C—H⋯O hydrogen bond occurs. A short Cl⋯Cl contact of 3.4027 (9) Å is present in the crystal structure. The crystal packing is further stabilized by weak C—H⋯π inter­actions