89 research outputs found
4-Hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-3,6-dihydro-2H-pyran-3-yl)(3-thienyl)methyl]-6-methyl-3,6-dihydro-2H-pyran-2-one
The asymmetric unit of the title compound, C17H14O6S, contains four crystallographically independent molecules in which the pyranone units are essentially planar, with maximum deviations of 0.016 (2), 0.019 (2), 0.025 (2), 0.014 (2), 0.020 (2), 0.010 (2), 0.003 (2) and 0.012 (2) Å. One of the thiophene rings is disordered over two positions, with an occupancy ratio of 0.739 (4):0.261 (4). The dihedral angles between the two pyranone rings in the independent molecules are 59.42 (8), 48.67 (8), 60.62 (9) and 51.60 (8)°. In the crystal, molecules are linked through intermolecular O—H⋯O and C—H⋯O hydrogen bonds, forming a three-dimensional network
3-[(E)-3-(2,4-Dichlorophenyl)prop-2-enoyl]-4-hydroxy-2H-chromen-2-one
In the title compound, C18H10Cl2O4, the chromen-2-one ring system is almost planar [maximum deviation = 0.028 (1) Å] and is inclined at an angle of 16.35 (4)° with respect to the benzene ring. The C=C bond has an E configuration. The molecular conformation is stabilized by an almost symmetric intramolecular O⋯H⋯O hydrogen bond and a C—H⋯O interaction, both of which form S(6) ring motifs. In the crystal structure, molecules are linked into sheets lying parallel to (100) via intermolecular C—H⋯O hydrogen bonds. The crystal packing is further consolidated by π–π stacking interactions [centroid-to-centroid separation = 3.6615 (6) Å]
4-Hydroxy-3-[(4-hydroxy-6,7-dimethyl-2-oxo-2H-chromen-3-yl)(4-oxo-4H-chromen-3-yl)methyl]-6,7-dimethyl-2H-chromen-2-one
In the title compound, C32H24O8, the molecular structure is disordered over two positions with refined site occupancies of 0.8746 (10) and 0.1254 (10). The mean plane of the three chromeno rings make dihedral angles with each other of 65.12 (4), 62.91 (4) and 59.70 (4)° in the major occupancy component and 59.1 (3), 66.1 (3) and 58.8 (3)° in the minor component. Intramolecular O—H⋯O hydrogen bonds stabilize the molecular structure and the crystal structure is stabilized by weak C–H⋯π and π–π interactions [centroid–centroid distances 3.496 (6)–3.672 (7) Å]
3-Methyl-4-[(E)-3-thienylmethylideneamino]-1H-1,2,4-triazole-5(4H)-thione
The asymmetric unit of the title compound, C8H8N4S2, contains two crystallographically independent molecules. The thiophene ring of one molecule is disordered over two positions with refined site occupancies of 0.6375 (19) and 0.3625 (19). One molecule is almost planar and the other one is twisted, the dihedral angles between the thiophene and triazole rings being 7.28 (7) and 48.9 (2)° [48.5 (4)° for the minor component], respectively. An intramolecular C—H⋯S hydrogen bond stabilizes the molecular conformation of the planar molecule. In the crystal, the two molecules are interconnected by N—H⋯S hydrogen bonds into dimers, which are further consolidated into chains along the b axis by C—H⋯N hydrogen bonds. Weak C–H⋯π and π–π interactions [centroid–centroid distance = 3.5149 (7) Å] are also observed
3-[5-(2,4-Dichlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxy-2H-chromen-2-one
In the title compound, C24H16Cl2N2O3, the chromene ring system is almost planar, with a maximum deviation of 0.042 (1) Å. It makes dihedral angles of 3.72 (6), 73.37 (5) and 12.00 (5)° with the dihydropyrazole, benzene and phenyl rings, respectively. An intramolecular O—H⋯N hydrogen bond forms an S(6) ring motif. In the crystal, molecules are linked via C—H⋯O interactions, forming an infinite chain along the a axis. The crystal packing is further stabilized by a π–π stacking interaction [centroid–centroid distance = 3.5471 (7) Å] and a Cl⋯Cl short contact [Cl⋯Cl = 3.214 (1) Å]
Assessment of thalassaemia service and community awareness in Kudat district
It was estimated that 3-5% of the Malaysian population are Beta-Thalassemia carriers, of which Malays are the majority. This study had probed into the service availability and
efforts given in its procedures to detect the cases and carriers and detennine the awareness of Thalassemia among community living in rural area of Sabah, Malaysia. A
cross-sectional survey on Thalassemia services was carried out in the hospital and health office of Kudat district, using quantitative and qualitative research methods .It was
designed to assess the healthcare service on Thalassemia, characteristics of target population, procedures of services provided, knowledge and opinion of health personnel
and communities staying in rural area of Kudat district. Purposive sample of villages were selected for the study, based on the presence of cases from secondary quantitative
data. Out of the total 139 respondents, only 89 (60.9%) claimed to know what Thalassemia is but very few had ever tested for Thalassemia. Although half of the
participants were aware of Thalassemia, their knowledge on Thalassemia was poor. Some of them knew how Thalassemia was transmitted through carrier of traits which can be
diagnosed but did not understand the burden of its chronicity. Most of them had never seen or know about the treatment let alone the prognosis of the illness. Analytical study of the data had shown that there was a statistically significant association between the awareness of Thalassemia and individuals of different ages (p<0.001), occupation
(p<0.002) and different education levels (p<0.00 1). In conclusion Thalassemia awareness among the rural community in Sabah, Malaysia was poor despite the high prevalence of
the disease carriers. Much effort on Health Education and Health Promotion should be made to improve the awareness of this illness among the rural Malaysian community if the prevalence was to reduce in future
9-(7-Fluoro-4-oxo-4H-chromen-3-yl)-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione
In the title compound, C26H25FO5, the terminal cyclohexane rings of the xanthene ring system adopt half-boat conformations. The 4H-chromene ring make a dihedral angle of 87.94 (5)° with the xanthene ring system and its carbonyl O atom lies above the xanthene O atom. In the crystal, molecules are linked into ribbons propagating along the a-axis direction by C—H⋯O hydrogen bonds. Aromatic π–π stacking interactions [centroid–centroid distance = 3.7367 (12) Å] also occur
3-Hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)(thiophen-3-yl)methyl]-5,5-dimethylcyclohex-2-en-1-one
The asymmetric unit of the title compound, C21H26O4S, consists of two independent molecules. In both molecules, intramolecular O—H⋯O hydrogen bonds stabilize the molecular structure. In the crystal, each molecule and its symmetry-related molecule by twofold rotation form a dimer through a pair of intermolecular C—H⋯O hydrogen bonds. In one of the molecules, the thiophene group is disordered over two sets of sites with occupancies of 0.735 (3) and 0.265 (3)
2-[(E)-(2,4-Dichlorobenzylidene)amino]isoindoline-1,3-dione
In the title compound, C15H8Cl2N2O2, the molecule adopts an E configuration about the central C=N double bond. The isoindoline ring is essentially planar, with a maximum deviation of 0.019 (2) Å. The dihedral angle between the isoindoline ring and the dichloro-substituted benzene ring is 6.54 (9)°. An intramolecular C—H⋯O hydrogen bond occurs. A short Cl⋯Cl contact of 3.4027 (9) Å is present in the crystal structure. The crystal packing is further stabilized by weak C—H⋯π interactions
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