Managing Operating Procedures in Distributed Collaborative Projects

In recent years, large distributed collaborative projects have become very prominent in scientific research, allowing exchanges between laboratories located in different institutions and countries and between various domains of competence. Particularly the work on nanotoxicity – a field which has only been under investigation for a few years and is still lacking regulatory framework – highlighted the need for well-controlled methods, as well as rules for the handling and disposal of used materials. To obtain comparable and reproducible results of experiments conducted in a distributed context, the standardisation and proper documentation of the applied methods is crucial. The European project NanoDiaRA, whose aim is to develop nanoparticles and biomarkers for the early diagnosis of inflammatory disease, faces this situation as it involves 15 European partners and brings together different scientific cultures and professional backgrounds. Protocols especially developed for Superparamagnetic Iron Oxide Nanoparticles and a management system were designed and implemented within the NanoDiaRA project to fulfil those needs. The main goals were the establishment of standardised Standard Operating Procedures assuring transparency and reproducibility and the provision of access to these protocols to every project partner, as well as their clear allocation to carry out precise measurements and production steps

Hitch-hiking effect and linkage disequilibrium: the example of two closely linked loci in the pig, Halothane Sensitivity (HAL) and Phosphohexose Isomerase (PHI)

International audienc

Absence of strong magnetic fluctuations in the iron phosphide superconductors LaFePO and Sr2ScO3FeP

We report neutron inelastic scattering measurements on polycrystalline LaFePO and Sr2ScO3FeP, two members of the iron phosphide families of superconductors. No evidence is found for any magnetic fluctuations in the spectrum of either material in the energy and wavevector ranges probed. Special attention is paid to the wavevector at which spin-density-wave-like fluctuations are seen in other iron-based superconductors. We estimate that the magnetic signal, if present, is at least a factor of four (Sr2ScO3FeP) or seven (LaFePO) smaller than in the related iron arsenide and chalcogenide superconductors. These results suggest that magnetic fluctuations are not as influential on the electronic properties of the iron phosphide systems as they are in other iron-based superconductors.Comment: 7 pages, 5 figure

Optimal and Efficient Decoding of Concatenated Quantum Block Codes

We consider the problem of optimally decoding a quantum error correction code -- that is to find the optimal recovery procedure given the outcomes of partial "check" measurements on the system. In general, this problem is NP-hard. However, we demonstrate that for concatenated block codes, the optimal decoding can be efficiently computed using a message passing algorithm. We compare the performance of the message passing algorithm to that of the widespread blockwise hard decoding technique. Our Monte Carlo results using the 5 qubit and Steane's code on a depolarizing channel demonstrate significant advantages of the message passing algorithms in two respects. 1) Optimal decoding increases by as much as 94% the error threshold below which the error correction procedure can be used to reliably send information over a noisy channel. 2) For noise levels below these thresholds, the probability of error after optimal decoding is suppressed at a significantly higher rate, leading to a substantial reduction of the error correction overhead.Comment: Published versio

Photometric stability analysis of the Exoplanet Characterisation Observatory

Photometric stability is a key requirement for time-resolved spectroscopic observations of transiting extrasolar planets. In the context of the Exoplanet Characterisation Observatory (EChO) mission design, we here present and investigate means of translating spacecraft pointing instabilities as well as temperature fluctuation of its optical chain into an overall error budget of the exoplanetary spectrum to be retrieved. Given the instrument specifications as of date, we investigate the magnitudes of these photometric instabilities in the context of simulated observations of the exoplanet HD189733b secondary eclipse.Comment: submitted to MNRA

Observation of magnetic fragmentation in spin ice

Fractionalised excitations that emerge from a many body system have revealed rich physics and concepts, from composite fermions in two-dimensional electron systems, revealed through the fractional quantum Hall effect, to spinons in antiferromagnetic chains and, more recently, fractionalisation of Dirac electrons in graphene and magnetic monopoles in spin ice. Even more surprising is the fragmentation of the degrees of freedom themselves, leading to coexisting and a priori independent ground states. This puzzling phenomenon was recently put forward in the context of spin ice, in which the magnetic moment field can fragment, resulting in a dual ground state consisting of a fluctuating spin liquid, a so-called Coulomb phase, on top of a magnetic monopole crystal. Here we show, by means of neutron scattering measurements, that such fragmentation occurs in the spin ice candidate Nd$_2$Zr$_2$O$_7$. We observe the spectacular coexistence of an antiferromagnetic order induced by the monopole crystallisation and a fluctuating state with ferromagnetic correlations. Experimentally, this fragmentation manifests itself via the superposition of magnetic Bragg peaks, characteristic of the ordered phase, and a pinch point pattern, characteristic of the Coulomb phase. These results highlight the relevance of the fragmentation concept to describe the physics of systems that are simultaneously ordered and fluctuating.Comment: accepted in Nature Physic

Antiferro-quadrupolar correlations in the quantum spin ice candidate Pr2Zr2O7

We present an experimental study of the quantum spin ice candidate pyrochlore coumpound \przr\ by means of magnetization measurements, specific heat and neutron scattering up to 12 T and down to 60 mK. When the field is applied along the $[111]$ and $[1\bar{1}0]$ directions, ${\bf k}=0$ field induced structures settle in. We find that the ordered moment rises slowly, even at very low temperature, in agreement with macroscopic magnetization. Interestingly, for $H \parallel [1\bar{1}0]$, the ordered moment appears on the so called $\alpha$ chains only. The spin excitation spectrum is essentially {\it inelastic} and consists in a broad flat mode centered at about 0.4 meV with a magnetic structure factor which resembles the spin ice pattern. For $H \parallel [1\bar{1}0]$ (at least up to 2.5 T), we find that a well defined mode forms from this broad response, whose energy increases with $H$, in the same way as the temperature of the specific heat anomaly. We finally discuss these results in the light of mean field calculations and propose a new interpretation where quadrupolar interactions play a major role, overcoming the magnetic exchange. In this picture, the spin ice pattern appears shifted up to finite energy because of those new interactions. We then propose a range of acceptable parameters for \przr\, that allow to reproduce several experimental features observed under field. With these parameters, the actual ground state of this material would be an antiferroquadrupolar liquid with spin-ice like excitations