1 research outputs found
Evaluation of antimicrobial Activities of isolated compounds from the leaf of the white specie of Sesamum Indicum from Benue State, Nigeria
The isolated compounds from the petroleum spirit, chloroform and
methanol crude leaf extracts of the white specie of the leaf of the
Sesamum Indicum used by traditional medicinal practitioners for the
management of infecticious diseases were investigated for in vitro
antimicrobial activity against some organisms. The various extracts
afforded compounds which had significant antimicrobial activities. The
antimicrobial screening showed that all the pure isolates from the
different solvent extracts were active against the organisms,
Staphylococcus aureus , Streptococcus pyogenes , Salmonella typhi ,
Candida albicans , Candida krusei , and Candida tropicalis at
various MIC\u2019s and (MBC/MFC)\u2019s. The pure isolates from
methanol and ethyl acetate fractions were all inactive against Bacillus
cereus , Corynebacterium ulcerans , and Escherichia coli . Only the
pure isolates from petroleum spirit and chloroform fractions showed
activity against Bacillus cereus, Corynebacterium ulcerans, and
Escherichia coli at an MIC of 0.5mg/ml and MCB/MFC of 1mg/ml.
Chromatographic techniques such as analytical TLC, Purification by dry
vacuum liquid chromatography (DVLC) and Preparative TLC were used