9 research outputs found
The furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study
Quality of care and safety measures of acute renal replacement therapy: Workgroup statements from the 22nd acute disease quality initiative (ADQI) consensus conference
The furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study
PurposeTo validate the furosemide stress test (FST) for predicting the progression of acute kidney injury (AKI).Materials and methodsWe performed a multicenter, prospective, observational study in patients with stage I or II AKI. The FST (1 mg/kg for loop diuretic naïve patients and 1.5 mg/kg in patients previously exposed to loop diuretics) was administered. Subsequent urinary flow rate (UFR) recorded and predictive ability of urinary output was measured by the area under the curve receiver operatic characteristics (AuROC). Primary outcome was progression to Stage III AKI. Secondary outcomes included in-hospital mortality and adverse events.ResultsWe studied 92 critically ill patients. 23 patients progressed to stage III AKI and had significantly lower UFR (p < 0.0001). The UFR during the first 2 h was most predictive of progression to stage III AKI (AuROC = 0.87), with an ideal cut-off of less than 200mls, with a sensitivity of 73.9% and specificity of 90.0%.ConclusionIn ICU patients without severe CKD with mild AKI, a UFR of less than 200mls in the first 2 h after an FST is predictive of progression to stage III AKI. Future studies should focus on incorporating a FST as part of a clinical decision tool for further management of critically ill patients with AKI
Association entre le taux d’occupation à l’unité de soins intensifs pendant l’admission et la mortalité hospitalière: une étude de cohorte rétrospective
Net ultrafiltration intensity and mortality in critically ill patients with fluid overload
The intensive care medicine agenda on acute kidney injury
SMB is supported by a Canada Research Chair in Critical Care Nephrology