177 research outputs found
実写画像を用いたイルミネーションモーフィング手法に関する検討
光源位置の異なる2枚の画像から、光源位置が徐々に変化する画像を生成するイルミネーションモーフィング(以下、ILM)手法が開発された。ILM手法は輝度値が連続的に変化する滑らかな面のみを対象としている。しかし、実写画像には微小な凹凸による陰影や汚れなどが存在し、輝度値のゆらぎが生じる。本稿ではILM手法の対象範囲を実写画像へ拡張するため、局所的に輝度値がゆらいでいる面を含む画像に拡張する方法を検討した。複数の要素関数の集合から成る輝度分布関数を用いて画像中の輝度分布を表現し、配置する要素関数に一定以上の半径を持つという条件を加えることで、局所的なゆらぎ成分を除いた輝度分布を得る。この処理により、輝度のゆらぎ成分を除いた輝度分布の形状変形を実現する
Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1-T587M
After taking an estrogen-containing supplement derived from a tropical plant Pueraria mirifica, a 24-year-old woman presented marked QT prolongation and repetitive torsade de pointes. The patient was found to carry a heterozygous KCNQ1-T587M mutation. This is the first report on Pueraria mirifica-related acquired long QT syndrome
DETERMINATION BY^1H-NMR OF BINDING SITES OF LOCAL ANESTHETICS ON LIPID BILAYER MEMBRANE MODEL
局所麻酔薬の作用機序についてはさまざまな仮説があるが,どの仮説も十分な説明をしていない。そこで我々は核磁気共鳴装置(NMR)を用いて,局所麻酔薬と神経膜モデルであるリン脂質二重膜との結合状態を検索した。この結果,局所麻酔薬分子中にある窒素原子とリン脂質二重膜の外側にある親水性部分の酸素原子とが静電結合をおこすことが分かった。また我々が作用持続時間の延長を目的に合成した,リドカインのエステル誘導体では窒素原子との結合に加えて,エステルカルボニル部分の酸素原子でも膜と結合することもわかった。さらに,この結合力の強さは局所麻酔薬の作用持続時間に影響することもわかった。これらの事実は一分子の局所麻酔薬が一つのNaイオンチャネルを閉鎖して局所麻酔作用を発現するのではなく,リン脂質二重膜と結合した多くの局所麻酔薬がNaイオンチャネルを構成するタンパク質の流動性を変化させ,結果的にNaイオンの通過を阻害して,局所麻酔作用を発現する可能性を示唆している。This is a study of the binding mode of local anesthtics to the phospholipid bilayer membrane model by proton nuclear masrnetic resonance spectroscopy (1^H-NMR). There was evidence of ionic interaction between the polar external hydrophilic part of the membrane and positively charged nitrogen atom of N-ethyl substituent of lidocaine molecule. Lidocaine ester derivatives, synthesized for prologed duration of action, indicated interaction with the membrane not only by positively charged nitrogen atoms but also by an electrostatic effect of the ester carbonyl oxygen atom. This may be related to the prolonged duration of lidocaine ester derivative action. The results indicate that a single molecule of local anesthetic does not close a single sodium channel. Many local anesthetic molecules bind to the phospholipid bilayer surounding sodium channels, and may bring some change in sodium channel protein comformation, and lead to the obstruction of the sodium ion passage
Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: a randomized, placebo-controlled, double-blind trial
BackgroundEnzymatically modified isoquercitrin (EMIQ), a water-soluble quercetin, has been shown to intensify muscle hypertrophy in mice. We investigated the effect of EMIQ in supplementary protein powder on athlete body composition.MethodsForty Japanese males who played American football (age: 19.8 ± 1.4 years; body height: 174.1 ± 6.0 cm; body mass: 75.5 ± 10.7 kg) were assigned to a randomized, placebo-controlled, double-blind trial of parallel group. Participants received either EMIQ in whey protein (EW, n = 19) or contrast whey protein (W, n = 20) 6 days per week over 4 months. Body composition was assessed using dual-energy X-ray absorptiometry. Markers of oxidative stress, derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), were assessed using a free radical analytical system. Data were analyzed using a univariate and repeated measures general model statistics.ResultsAfter 4 months, changes in lower limb fat-free mass and muscle mass were significantly greater in the EW group than in the W group (mean change ±95% CI; W: 324.1 ± 284.3, EW: 950.3 ± 473.2, p = 0.031, W: 255.7 ± 288.6, EW: 930.9 ± 471.5, p = 0.021, respectively). Moreover, the EW group exhibited a significantly higher BAP/d-ROMs ratio, antioxidation index, than the W group after 4 months (mean change ± SD; W: 8.8 ± 1.1, EW: 10.3 ± 2.8; p = 0.028). No significant differences in body mass, lean body mass, fat mass, or lower limb fat mass were observed between the groups.ConclusionIngestion of EMIQ in supplementary protein powder for 4 months exerts antioxidant effects and increases muscle mass among American football players
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