On Neutrino Emission From Dense Matter Containing Meson Condensates

We consider the rate at which energy is emitted by neutrinos from the dense interior of neutron stars containing a Bose condensate of pions or kaons. The rates obtained are larger, by a factor of 2, than those found earlier, and are consistent with those found for the direct Urca processes.Comment: RevTeX, 10 page

Nonequilibrium Weak Processes in Kaon Condensation II - Kinetics of condensation ---

The kinetics of negatively charged kaon condensation in the early stages of a newly born neutron star is considered. The thermal kaon process, in which kaons are thermally produced by nucleon-nucleon collisions, is found to be dominant throughout the equilibration process. Temporal changes of the order parameter of the condensate and the number densities of the chemical species are obtained from the rate equations, which include the thermal kaon reactions as well as the kaon-induced Urca and the modified Urca reactions. It is shown that the dynamical evolution of the condensate is characterized by three stages: the first, prior to establishment of a condensate, the second, during the growth and subsequent saturation of the condensate, and the third, near chemical equilibrium. The connection between the existence of a soft kaon mode and the instability of the noncondensed state is discussed. Implications of the nonequilibrium process on the possible delayed collapse of a protoneutron star are also mentioned.Comment: 27 pages, incl. 8 eps figures, RevTe

Altered fibroblast proteoglycan production in COPD

<p>Abstract</p> <p>Background</p> <p>Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role in this process as regulators of the integrity of the extracellular matrix. Altered proteoglycan immunostaining has been demonstrated in COPD lungs and this has been suggested to contribute to the pathogenesis. The major cell type responsible for production and maintenance of ECM constituents, such as proteoglycans, are fibroblasts. Interestingly, it has been proposed that central airways and alveolar lung parenchyma contain distinct fibroblast populations. This study explores the hypothesis that altered depositions of proteoglycans in COPD lungs, and in particular versican and perlecan, is a result of dysregulated fibroblast proteoglycan production.</p> <p>Methods</p> <p>Proliferation, proteoglycan production and the response to TGF-β₁were examined <it>in vitro </it>in centrally and distally derived fibroblasts isolated from COPD patients (GOLD stage IV) and from control subjects.</p> <p>Results</p> <p>Phenotypically different fibroblast populations were identified in central airways and in the lung parenchyma. Versican production was higher in distal fibroblasts from COPD patients than from control subjects (p < 0.01). In addition, perlecan production was lower in centrally derived fibroblasts from COPD patients than from control subjects (p < 0.01). TGF-β₁triggered similar increases in proteoglycan production in distally derived fibroblasts from COPD patients and control subjects. In contrast, centrally derived fibroblasts from COPD patients were less responsive to TGF-β₁than those from control subjects.</p> <p>Conclusions</p> <p>The results show that fibroblasts from COPD patients have alterations in proteoglycan production that may contribute to disease development. Distally derived fibroblasts from COPD patients have enhanced production of versican that may have a negative influence on the elastic recoil. In addition, a lower perlecan production in centrally derived fibroblasts from COPD patients may indicate alterations in bronchial basement membrane integrity in severe COPD.</p

Nonequilibrium Weak Processes in Kaon Condensation I --- Reaction rate for the thermal kaon process ---

We investigate the thermal kaon process,in which kaons are thermally produced via nucleon-nucleon collisions.This process is relevant to nonequilibrium dynamics of kaon condensation inside neutron stars.The reaction rates for these processes are calculated, and their temperature and density dependences are compared with those of other reaction rates.It is shown that the thermal kaon process is dominant over other relevant weak reactions throughout the nonequilibrium process, such as the kaon-induced Urca and the modified Urca reactions, and may control the entire evolution of the kaon condensate. The characteristic role of the soft and hard kaons during the evolution is explained, and implications for astrophysical phenomena are briefly discussed.Comment: 31 pages,incl.10 eps figures,RevTe

MITF has a central role in regulating starvation-induced autophagy in melanoma.

The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that MITF binds the CLEAR-box element in the promoters of lysosomal and autophagosomal genes in melanocytes and melanoma cells. The crystal structure of MITF bound to the CLEAR-box reveals how the palindromic nature of this motif induces symmetric MITF homodimer binding. In metastatic melanoma tumors and cell lines, MITF positively correlates with the expression of lysosomal and autophagosomal genes, which, interestingly, are different from the lysosomal and autophagosomal genes correlated with TFEB and TFE3. Depletion of MITF in melanoma cells and melanocytes attenuates the response to starvation-induced autophagy, whereas the overexpression of MITF in melanoma cells increases the number of autophagosomes but is not sufficient to induce autophagic flux. Our results suggest that MITF and the related factors TFEB and TFE3 have separate roles in regulating a starvation-induced autophagy response in melanoma. Understanding the normal and pathophysiological roles of MITF and related transcription factors may provide important clinical insights into melanoma therapy

Neutron Star Constraints on the H Dibaryon

We study the influence of a possible H dibaryon condensate on the equation of state and the overall properties of neutron stars whose population otherwise contains nucleons and hyperons. In particular, we are interested in the question of whether neutron stars and their masses can be used to say anything about the existence and properties of the H dibaryon. We find that the equation of state is softened by the appearance of a dibaryon condensate and can result in a mass plateau for neutron stars. If the limiting neutron star mass is about that of the Hulse-Taylor pulsar a condensate of H dibaryons of vacuum mass 2.2 GeV and a moderately attractive potential in the medium could not be ruled out. On the other hand, if the medium potential were even moderately repulsive, the H, would not likely exist in neutron stars. If neutron stars of about 1.6 solar mass were known to exist, attractive medium effects for the H could be ruled out. Certain ranges of dibaryon mass and potential can be excluded by the mass of the Hulse-Taylor pulsar which we illustrate graphically.Comment: Revised by the addition of a figure showing the region of dibaryon mass and potential excluded by the Hulse-Taylor pulsar. 18 pages, 11 figures, latex (submitted to Phys. Rev. C

Scaling Of Chiral Lagrangians And Landau Fermi Liquid Theory For Dense Hadronic Matter

We discuss the Fermi-liquid properties of hadronic matter derived from a chiral Lagrangian field theory in which Brown-Rho (BR) scaling is incorporated. We identify the BR scaling as a contribution to Landau's Fermi liquid fixed-point quasiparticle parameter from "heavy" isoscalar meson degrees of freedom that are integrated out from a low-energy effective Lagrangian. We show that for the vector (convection) current, the result obtained in the chiral Lagrangian approach agrees precisely with that obtained in the semi-phenomenological Landau-Migdal approach. This precise agreement allows one to determine the Landau parameter that enters in the effective nucleon mass in terms of the constant that characterizes BR scaling. When applied to the weak axial current, however, these two approaches differ in a subtle way. While the difference is small numerically, the chiral Lagrangian approach implements current algebra and low-energy theorems associated with the axial response that the Landau method misses and hence is expected to be more predictive.Comment: 39 pages, latex with 4 eps figure, modified addresses and reference

Neutrino Opacities in Neutron Stars with Kaon Condensates

The neutrino mean free paths in hot neutron-star matter are obtained in the presence of kaon condensates. The kaon-induced neutrino absorption process, which is allowed only in the presence of kaon condensates, is considered for both nondegenerate and degenerate neutrinos. The neutrino mean free path due to this process is compared with that for the neutrino-nucleon scattering. While the mean free path for the kaon-induced neutrino absorption process is shown to be shorter than the ordinary two-nucleon absorption process by several orders of magnitude when temperature is not very high, the neutrino-nucleon scattering process has still a dominant contribution to the neutrino opacity. Thus, the kaon-induced neutrino absorption process has a minor effect on the thermal and dynamical evolution of protoneutron stars.Comment: 35 pages, 4 figure

Analysing the Large Decline in Coronary Heart Disease Mortality in the Icelandic Population Aged 25-74 between the Years 1981 and 2006

BACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in cardiovascular risk factors. METHODOLOGY: The previously validated IMPACT CHD mortality model was applied to the Icelandic population. The data sources were official statistics, national quality registers, published trials and meta-analyses, clinical audits and a series of national population surveys. PRINCIPAL FINDINGS: Between 1981 and 2006, CHD mortality rates in Iceland decreased by 80% in men and women aged 25 to 74 years, which resulted in 295 fewer deaths in 2006 than if the 1981 rates had persisted. Incidence of myocardial infarction (MI) decreased by 66% and resulted in some 500 fewer incident MI cases per year, which is a major determinant of possible deaths from MI. Based on the IMPACT model approximately 73% (lower and upper bound estimates: 54%-93%) of the mortality decrease was attributable to risk factor reductions: cholesterol 32%; smoking 22%; systolic blood pressure 22%, and physical inactivity 5% with adverse trends for diabetes (-5%), and obesity (-4%). Approximately 25% (lower and upper bound estimates: 8%-40%) of the mortality decrease was attributable to treatments in individuals: secondary prevention 8%; heart failure treatments 6%; acute coronary syndrome treatments 5%; revascularisation 3%; hypertension treatments 2%, and statins 0.5%. CONCLUSIONS: Almost three quarters of the large CHD mortality decrease in Iceland between 1981 and 2006 was attributable to reductions in major cardiovascular risk factors in the population. These findings emphasize the value of a comprehensive prevention strategy that promotes tobacco control and a healthier diet to reduce incidence of MI and highlights the potential importance of effective, evidence based medical treatments