Megabits secure key rate quantum key distribution

Quantum cryptography (QC) can provide unconditional secure communication between two authorized parties based on the basic principles of quantum mechanics. However, imperfect practical conditions limit its transmission distance and communication speed. Here we implemented the differential phase shift (DPS) quantum key distribution (QKD) with up-conversion assisted hybrid photon detector (HPD) and achieved 1.3 M bits per second secure key rate over a 10-km fiber, which is tolerant against the photon number splitting (PNS) attack, general collective attacks on individual photons, and any other known sequential unambiguous state discrimination (USD) attacks.Comment: 14 pages, 4 figure

Long-distance entanglement-based quantum key distribution over optical fiber

We report the first entanglement-based quantum key distribution (QKD) experiment over a 100-km optical fiber. We used superconducting single photon detectors based on NbN nanowires that provide high-speed single photon detection for the 1.5-µm telecom band, an efficient entangled photon pair source that consists of a fiber coupled periodically poled lithium niobate waveguide and ultra low loss filters, and planar lightwave circuit Mach-Zehnder interferometers (MZIs) with ultra stable operation. These characteristics enabled us to perform an entanglement-based QKD experiment over a 100-km optical fiber. In the experiment, which lasted approximately 8 hours, we successfully generated a 16 kbit sifted key with a quantum bit error rate of 6.9 % at a rate of 0.59 bits per second, from which we were able to distill a 3.9 kbit secure key

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Photocurrent spectra and Wannier-Stark localization of In0.53Ga0.47As/InP superlattices with different barrier thicknesses

Wannier-Stark localization in a pair of high quality lattice-matchedInGaAs/InP superlattices (SL) p-i-n diodes with wide (60 meV) and narrow(14 meV) electron miniband widths has been investigated by roomtemperature photocurrent (PC) response measurements. PC spectra as wellas PC versus reverse bias voltage characteristics of the SL samples exhibit aclear excitonic absorption edge redshifted due to the miniband formationand show distinct Stark ladder transitions, which evolve with the appliedelectric field. The transition energy fan diagrams are analyzed for the SLmodel potential structures using transfer matrix calculations. It is foundthat observed blueshifts of the absorption edge by decreasing the minibandwidth and by increasing the field exactly coincide with half of the transitionminiband width, thus providing the electroabsorption modulation withInGaAs/InP SL\u27s. Good agreement of the transition energies is obtainedbetween theory and experiment, using band offset and effective massparameters proposed by Gershoni et al., Phys. Rev. B38, 7870 (1988)

Ultra-long distance and efficient entanglement distribution over 200 kilometers

Entanglement distribution over 200 kilometers of optical fiber is demonstrated with practical, low-cost, InGaAs avalanche photodiodes. High coincidence count rates are also observed indicating entangled based quantum key distribution is feasible over ultra-long distances. © 2009 Optical Society of America